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Long-Term Depression: A Cellular Basis for Learning?

Long-Term Depression: A Cellular Basis for Learning? © Freund & Pettman, U.K. , 12, 121-140 (2001) Karl-Heinz Braunewell and Denise Manahan-Vaughan Signal Transduction Research Group, Neuroscience Research Center of the Charite, Humboldt Universityand 2Synaptic Plasticity Research Group, Johannes Mueller Institute for Physiology, Humboldt University Medical Faculty (Charite), Berlin, Germany CONTENTS Synopsis 1. Introduction 2. Inducing LTD in the Hippocampus of Freely Moving Rats 3. Metaplasticity of LTD 4. Molecular Mechanisms of LTD - Comparison with LTP 4.1. Neurotransmitter receptors: Inducing and modulating synaptic plasticity 4.2 Pre- and postsynaptic signalling pathways 4.2.1 Presynaptic neurotransmitter receptors and retrograde signalling mechanisms 4.2.2 NMDA receptor coupled postsynaptic signalling pathways 4.2.3 mGluR coupled signalling pathways 4.2.4 Complexity and cross-talk of pathways leading to phosphorylation and dephosphorylation of receptors and channels 4.3 4.4 Maintenance of LTD: Late phase and gene expression LTD is more than the reverse mechanism of LTP: Insights from knockout studies 5. LTD and Learning 6. Perspectives: LTD as a Memory Shaping Mechanism References Accepted: 20 September, 2000 Reprint address: Dr. D. Manahan-Vaughan Synaptic Plasticity Research Group Johannes Mueller Institute for Physiology Humboldt University Medical Faculty (Charite) Tucholskystr. 2 D-10117 Berlin, Germany e-mail: denise.manahan-vaughan@charite.de SYNOPSIS Long-term depression (LTD) comprises a persistent activity-dependent reduction in synaptic efficacy which typically http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reviews in the Neurosciences de Gruyter

Long-Term Depression: A Cellular Basis for Learning?

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References (42)

Publisher
de Gruyter
Copyright
Copyright © 2001 by the
ISSN
2191-0200
eISSN
2191-0200
DOI
10.1515/REVNEURO.2001.12.2.121
Publisher site
See Article on Publisher Site

Abstract

© Freund & Pettman, U.K. , 12, 121-140 (2001) Karl-Heinz Braunewell and Denise Manahan-Vaughan Signal Transduction Research Group, Neuroscience Research Center of the Charite, Humboldt Universityand 2Synaptic Plasticity Research Group, Johannes Mueller Institute for Physiology, Humboldt University Medical Faculty (Charite), Berlin, Germany CONTENTS Synopsis 1. Introduction 2. Inducing LTD in the Hippocampus of Freely Moving Rats 3. Metaplasticity of LTD 4. Molecular Mechanisms of LTD - Comparison with LTP 4.1. Neurotransmitter receptors: Inducing and modulating synaptic plasticity 4.2 Pre- and postsynaptic signalling pathways 4.2.1 Presynaptic neurotransmitter receptors and retrograde signalling mechanisms 4.2.2 NMDA receptor coupled postsynaptic signalling pathways 4.2.3 mGluR coupled signalling pathways 4.2.4 Complexity and cross-talk of pathways leading to phosphorylation and dephosphorylation of receptors and channels 4.3 4.4 Maintenance of LTD: Late phase and gene expression LTD is more than the reverse mechanism of LTP: Insights from knockout studies 5. LTD and Learning 6. Perspectives: LTD as a Memory Shaping Mechanism References Accepted: 20 September, 2000 Reprint address: Dr. D. Manahan-Vaughan Synaptic Plasticity Research Group Johannes Mueller Institute for Physiology Humboldt University Medical Faculty (Charite) Tucholskystr. 2 D-10117 Berlin, Germany e-mail: denise.manahan-vaughan@charite.de SYNOPSIS Long-term depression (LTD) comprises a persistent activity-dependent reduction in synaptic efficacy which typically

Journal

Reviews in the Neurosciencesde Gruyter

Published: Apr 1, 2001

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