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Local cerebral glucose utilisation following acute and chronic bilateral carotid artery ligation in Wistar rats: relation to changes in local cerebral blood flow

Local cerebral glucose utilisation following acute and chronic bilateral carotid artery ligation... 221 95 95 1 1 Masahiko Tsuchiya Kazuhiro Sako Shigeki Yura Yukichi Yonemasu Department of Neurosurgery Asahikawa Medical College 078 Asahikawa Japan Department of Pharmacology Asahi Chemical Industry Co. Ltd. 6-2700 Asahimachi 882 Nobeoka Japan Abstract The effects on local cerebral blood flow (LCBF) and glucose utilisation (LCGU) of permanent, bilateral carotid artery ligation (BCAL) were studied in conscious Wistar rats. LCBF and LCGU were measured using quantitative autoradiographic 14 C-iodoantipyrine and the 14 C-2-deoxyglucose ( 14 C-DG) techniques in 24 anatomically discrete regions of the brain. LCBF in the cerebral hemispheres 2.5 h (acute) after BCAL significantly decreased to 25–87% of the sham control, with the exception of the mammillary body. After acute BCAL, there was a heterogeneous accumulation of 14 C-DG in the caudate nucleus and cerebral cortices. Only in the lateral geniculate body did LCGU significantly decrease after BCAL. One week (chronic) later, LCBF was significantly decreased in 15 (containing the caudate nucleus and all the cerebral cortices) of 24 structures. LCGU in ten (containing the caudate nucleus and all the cerebral cortices) of 24 structures after chronic BCAL significantly decreased to 66–77% of the sham control, except for regions with neuronal damage in which there was a heterogeneous uptake of 14 C-DG. The ratio of LCBF/ LCGU in chronic BCAL was unchanged in comparison with values in the corresponding sham-operated group. This model of acute and chronic cerebral ischaemia, with impairment in cerebral circulation and/or glucose metabolism, is expected to become a pertinent tool for the neurophysiologist. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Experimental Brain Research Springer Journals

Local cerebral glucose utilisation following acute and chronic bilateral carotid artery ligation in Wistar rats: relation to changes in local cerebral blood flow

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References (14)

Publisher
Springer Journals
Copyright
Copyright © 1993 by Springer-Verlag
Subject
Biomedicine; Neurosciences; Neurology
ISSN
0014-4819
eISSN
1432-1106
DOI
10.1007/BF00229648
Publisher site
See Article on Publisher Site

Abstract

221 95 95 1 1 Masahiko Tsuchiya Kazuhiro Sako Shigeki Yura Yukichi Yonemasu Department of Neurosurgery Asahikawa Medical College 078 Asahikawa Japan Department of Pharmacology Asahi Chemical Industry Co. Ltd. 6-2700 Asahimachi 882 Nobeoka Japan Abstract The effects on local cerebral blood flow (LCBF) and glucose utilisation (LCGU) of permanent, bilateral carotid artery ligation (BCAL) were studied in conscious Wistar rats. LCBF and LCGU were measured using quantitative autoradiographic 14 C-iodoantipyrine and the 14 C-2-deoxyglucose ( 14 C-DG) techniques in 24 anatomically discrete regions of the brain. LCBF in the cerebral hemispheres 2.5 h (acute) after BCAL significantly decreased to 25–87% of the sham control, with the exception of the mammillary body. After acute BCAL, there was a heterogeneous accumulation of 14 C-DG in the caudate nucleus and cerebral cortices. Only in the lateral geniculate body did LCGU significantly decrease after BCAL. One week (chronic) later, LCBF was significantly decreased in 15 (containing the caudate nucleus and all the cerebral cortices) of 24 structures. LCGU in ten (containing the caudate nucleus and all the cerebral cortices) of 24 structures after chronic BCAL significantly decreased to 66–77% of the sham control, except for regions with neuronal damage in which there was a heterogeneous uptake of 14 C-DG. The ratio of LCBF/ LCGU in chronic BCAL was unchanged in comparison with values in the corresponding sham-operated group. This model of acute and chronic cerebral ischaemia, with impairment in cerebral circulation and/or glucose metabolism, is expected to become a pertinent tool for the neurophysiologist.

Journal

Experimental Brain Research – Springer Journals

Published: Jul 1, 1993

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