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PYODERMA GANGRENOSUM: THE HISTOLOGY OF THE PRIMARY LESION. *

PYODERMA GANGRENOSUM: THE HISTOLOGY OF THE PRIMARY LESION. * Edinburgh University. APART from varicose or hy]Mstatic ulcers and so-called tropical ulcers, progressive widesjiread primary cutaneous ulceration is rarely seen. It is usually associated with some visceral disorder and from this standjioint cases can be divided broadly into two gnui]>s : (i) Chronic infections or synergist ic cutaneous gangrene described by Meleney, which is associated with empyema or other visceral sepsis and develojM as a post-operative complication, (ii) Ciironic (ihagedcnie ulceration, which occurs in association with ulcerativc colitis. The tcriu pyodernia gangrenosum covers both gi'oups. but to avoid ambignity in this jiaiK-r it will be limited to tbe second. In both groups there is a background of debility. Various organisms have been isolated from the nleei-s and the cutaneous lesions do not re.s])ond to local antiseptic treatment or to systemic chemotherapy and antibiotics. There is no conclusive evidence that the cutaneous lesions in the two groujis represent the same j)rocess. For the present, they may be regarded as distinct from one another since Meleney's ulcer mostly develops in direct anatomical contiiniity with a foeus of visceral sei)sis. whereas pyoderma gangrenosum eared in dermatological literature ; these have been summarised Ly Russell (1050) and by Clarke (1955). In the http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png British Journal of Dermatology Wiley

PYODERMA GANGRENOSUM: THE HISTOLOGY OF THE PRIMARY LESION. *

British Journal of Dermatology , Volume 69 (4) – Apr 1, 1957

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References (5)

Publisher
Wiley
Copyright
Copyright © 1957 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0007-0963
eISSN
1365-2133
DOI
10.1111/j.1365-2133.1957.tb13243.x
Publisher site
See Article on Publisher Site

Abstract

Edinburgh University. APART from varicose or hy]Mstatic ulcers and so-called tropical ulcers, progressive widesjiread primary cutaneous ulceration is rarely seen. It is usually associated with some visceral disorder and from this standjioint cases can be divided broadly into two gnui]>s : (i) Chronic infections or synergist ic cutaneous gangrene described by Meleney, which is associated with empyema or other visceral sepsis and develojM as a post-operative complication, (ii) Ciironic (ihagedcnie ulceration, which occurs in association with ulcerativc colitis. The tcriu pyodernia gangrenosum covers both gi'oups. but to avoid ambignity in this jiaiK-r it will be limited to tbe second. In both groups there is a background of debility. Various organisms have been isolated from the nleei-s and the cutaneous lesions do not re.s])ond to local antiseptic treatment or to systemic chemotherapy and antibiotics. There is no conclusive evidence that the cutaneous lesions in the two groujis represent the same j)rocess. For the present, they may be regarded as distinct from one another since Meleney's ulcer mostly develops in direct anatomical contiiniity with a foeus of visceral sei)sis. whereas pyoderma gangrenosum eared in dermatological literature ; these have been summarised Ly Russell (1050) and by Clarke (1955). In the

Journal

British Journal of DermatologyWiley

Published: Apr 1, 1957

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