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Cytokine-Induced Modulation of Cardiac Function

Cytokine-Induced Modulation of Cardiac Function Reviews This Review is part of a thematic series on Chemokines and Cytokines, which includes the following articles: Inflammatory Mediators and the Failing Heart: Past, Present, and the Foreseeable Future Inflammatory Cytokines and Postmyocardial Infarction Remodeling Chemokines in the Pathogenesis of Vascular Disease Peter Liu, Guest Editor Sumanth D. Prabhu Abstract—Cytokines act in an autocrine and/or paracrine fashion to induce a diverse variety of biological responses. Several cardiac diseases are associated with cytokine activation, and such activation significantly influences several physiologic parameters, including cardiac mechanical function. This review summarizes the current concepts regarding the modulation of myocardial function by cytokines and provides rationale for the sometimes-conflicting results in the literature regarding underlying mechanisms and patterns of dysfunction. Although traditionally considered cardiode- pressant mediators, contractile responses are complex and bimodal, with an early response (within minutes) of variable direction, stimulatory or depressant, depending on the ambient physiologic milieu and relative contributions of the underlying signaling pathways that are activated. These pathways include sphingomyelinase-, nitric oxide (NO)-, and phospholipase A2-dependent signaling with resultant combined effects on contraction and the Ca transient. This is subsequently followed by a profoundly cardiodepressant late response lasting hours to days, depending on the production of secondary http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Circulation Research Wolters Kluwer Health

Cytokine-Induced Modulation of Cardiac Function

Prabhu, Sumanth D.
Circulation Research , Volume 95 (12) – Dec 1, 2004
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References (124)

ISSN
0009-7330
eISSN
1524-4571
DOI
10.1161/01.RES.0000150734.79804.92
pmid
15591236
Publisher site
See Article on Publisher Site

Abstract

Reviews This Review is part of a thematic series on Chemokines and Cytokines, which includes the following articles: Inflammatory Mediators and the Failing Heart: Past, Present, and the Foreseeable Future Inflammatory Cytokines and Postmyocardial Infarction Remodeling Chemokines in the Pathogenesis of Vascular Disease Peter Liu, Guest Editor Sumanth D. Prabhu Abstract—Cytokines act in an autocrine and/or paracrine fashion to induce a diverse variety of biological responses. Several cardiac diseases are associated with cytokine activation, and such activation significantly influences several physiologic parameters, including cardiac mechanical function. This review summarizes the current concepts regarding the modulation of myocardial function by cytokines and provides rationale for the sometimes-conflicting results in the literature regarding underlying mechanisms and patterns of dysfunction. Although traditionally considered cardiode- pressant mediators, contractile responses are complex and bimodal, with an early response (within minutes) of variable direction, stimulatory or depressant, depending on the ambient physiologic milieu and relative contributions of the underlying signaling pathways that are activated. These pathways include sphingomyelinase-, nitric oxide (NO)-, and phospholipase A2-dependent signaling with resultant combined effects on contraction and the Ca transient. This is subsequently followed by a profoundly cardiodepressant late response lasting hours to days, depending on the production of secondary

Journal

Circulation Research – Wolters Kluwer Health

Published: Dec 1, 2004

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