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(1976)
Preleukemic states . 11 : Refractory anemia with an excess of myeloblasts in the bone marrow
H. Preisler, G. Lyman (1977)
Acute myelogenous leukemia subsequent to therapy for a different neoplasm: Clinical features and response to therapyAmerican Journal of Hematology, 3
M. Keating, T. Smith, K. McCredie, G. Bodey, E. Hersh, J. Gutterman, E. Gehan, E. Freireich (1981)
A four‐year experience with anthracycline, cytosine arabinoside, vincristine and prednisone combination chemotherapy in 325 adults with acute leukemiaCancer, 47
G. Bodey, K. McCredie, M. Keating, E. Freireich (1979)
Treatment of acute leukemia in protected environment unitsCancer, 44
Sakurai Sakurai, Sandberg Sandberg (1976)
Correlations of karyotypes with clinical features of acute myeloblastic leukemiaCancer, 37
G. Dosik, B. Barlogie, T. Smith, E. Gehan, M. Keating, K. McCredie, E. Freireich (1980)
Pretreatment flow cytometry of DNA content in adult acute leukemia.Blood, 55 3
H. Golomb, J. Vardiman, J. Rowley (1976)
Acute nonlymphocytic leukemia in adults: correlations with Q-banded chromosomes.Blood, 48 1
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Clinical implications of aneuploid cyto genetic profiles in adult acute leukemiaCancer, 33
D. Law, S. Dudrick, N. Abdou (1973)
Immunocompetence of patients with protein-calorie malnutrition.Annals of Internal Medicine, 79
T. Smith, E. Gehan, M. Keating, E. Freireich (1982)
Prediction of remission in adult acute leukemia. Development and testing of predictive modelsCancer, 50
E. Freireich, E. Gehan, G. Bodey (1974)
New prognostic factors affecting response and survival in adult acute leukemiaTransactions of the Association of American Physicians, 87
J. Trujillo, A. Cork, M. Ahearn, E. Youness, K. McCredie (1979)
Hematologic and cytologic characterization of 8/21 translocation acute granulocytic leukemia.Blood, 53 4
E. Gehan, T. Smith, E. Freireich, G. Bodey, V. Rodriquez, J. Speer, K. McCredie (1976)
Prognostic factors in acute leukemia.Seminars in oncology, 3 3
M. Sakurai, A. Sandberg (1976)
Chromosomes and causation of human cancer and leukemia. XI. Correlation of karyotypes with clinical features of acute myeloblastic leukemiaCancer, 37
J. Holland, O. Glidewell, R. Ellison, Robert Corey, Joel Schwartz, H. Wallace, H. Hoagland, P. Wiernik, K. Rai, J. Bekesi, J. Cuttner (1976)
Acute myelocytic leukemia.Archives of internal medicine, 136 12
D. Law, S. Dudrick, N. Abdou (1973)
Immunocompetence of patients with protein-calorie malnutrition. The effects of nutritional repletion.Annals of internal medicine, 79 4
M. Keating, T. Smith, E. Gehan, K. McCredie, G. Bodey, G. Spitzer, E. Hersh, J. Gutterman, E. Freireich (1980)
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(1975)
The usefulness of multiple pretreatment patient characteristics for prediction of response and survival in patients with adult acute leukemia
Y. Najean, A. Pecking (1977)
Refractory Anaemia with Excess of Myeloblasts in the Bone Marrow: a Clinical Trial of Androgens in 90 PatientsBritish Journal of Haematology, 37
The pretreatment characteristics of 325 adults with acute leukemia who were treated at the M. D. Anderson Hospital between 1973 and 1977 have been evaluated to assess their value as prognostic indicators. The patient population includes all patients treated with an anthracycline (Adriamycin or rubidazone), cytosine arabinoside, vincristine, and prednisone during the time period. Most patients had one of the variants of acute myelogenous leukemia (75%), and the remaining patients had acute lymphoblastic leukemia (16%) or undifferentiated leukemia (8%). Twenty‐one factors were found to be significantly associated with probability of obtaining a complete response. In addition to characteristics previously known to provide prognostic information such as age, temperature status at the start of treatment, morphology, the presence of Auer rods, sex, and hemoglobin level, we identified the presence of a documented antecedent hematologic disorder and the finding of insufficient metaphases on cytogenetic analysis using the squash technique as being major prognostic variables. In addition, the pre‐treatment biochemical characteristics of hypoalbuminemia and elevated blood urea nitrogen and creatinine were found to adversely influence prognosis. The prognostic significance of factors such as the leukocyte count and platelet count, identified in earlier studies, was not confirmed in this group of patients. From this natural‐history analysis predictive models for response have been developed using multivariate logistic regression techniques. One of these models has been used to evaluate the effect of morphology, treatment, and cytogenetic pattern on response to the combination of drugs used.
Cancer – Wiley
Published: Aug 1, 1982
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