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Summary: The effects of glutamate and aspartate antagonists were studied on limb‐jerk frequency and EEG patterns in rats made epileptic by cobalt implantation in the sensorimotor cerebral cortex. The results of this study were as follows: (1) a‐Amino‐4‐phosphonobutyric acid (0.055‐1.10 mM) decreased or complétély prevented the epileptic manifestations. The effect was reversible 30 min after washing with artificial CSF solution. (2) DL‐Pyroglutamic acid complétély abolished the myoclonic jerks and EEG spikes. (3) α‐Amino‐5‐phos‐phonovaleric acid and a‐D‐amino‐adipic acid significantly reduced the frequency of epileptic spikes and myoclonic jerks. (4) Other analogs, a‐amino‐3‐phosphonopropionic acid (0.6 mM), α‐amino phosphonocaproic acid (0.95), and hydroxy‐3‐amino pyrrolidone‐2 were without effect. (5) Glutamate itself did not decrease the epileptic manifestations. RÉSUMÉ Les auteurs ont étudié les effets d'antagonistes du glutamate et de l'aspartate sur la fréquence des clonies des membres et sur I'EEG de rats rendus épileptiques par I'implantation de cobalt dans le cortex cérébral sensori‐moteur. (1) I'acide α‐amino‐4‐phosphonobuty‐rique (APBA) (0,055‐1,10 mM) diminue ou empêche même complétèment la survenue de manifestations épileptiques. L'effet est réversible 30 minutes après le lavage par une solution artificielle de LCR. (2) I'acide DL‐pyroglutamique (DL‐PY) supprime completèment les secousses myocloniques et les pointes EEG. (3) I'acide α‐amino‐5‐phosphono valérique (APVA) et I'acide α‐D‐amino‐adipique (DαAA) di‐minuent de façon significative la fréquence des pointes épileptiques et des secousses myocloniques. (4) d'autres substances analogues, I'acide α‐amino‐3‐phosphono‐propionique (APPA) (0,6 mM), I'acide α‐amino‐phosphono‐caproique (APCA) (0,95) et l'hydroxy‐3‐amino‐pyrrolidone‐2 (HA966), sont sans effet. (5) le glutamate lui même ne diminue pas les manifestations épileptiques. RESUMEN Se han estudiado los efectos de los antagonistas del glutamato y del aspartato sobre la frecuencia de las contracciones musculares de las extremidades y sobre los patrones del EEG de ratas convertidas en epilépticas mediante implantación de cobalto en la corteza cerebral sensoriai‐motora. (I) El ácido α‐amino‐4‐fósfono‐butírico (APBA) (0.005‐1.10 mM) redujo o evitó completamente las manifestaciones epilépticas. El efecto se hizo reversible 30 min después del lavado con liquido céfalo‐raquideo artificial. (2) El ácido DL‐piroglutámico (DL‐PY) abolió completamente las mioclonias y las puntas en el EEG. (3) El ácido α‐amino‐5‐fosfono valérico (APVA) y el ácido á‐D‐amino‐adipico (DαAA) redujeron de modo sig‐nificativo la frecuencia de las puntas epilépticas y las mioclonias. (4) Otros análogos, el ácido α‐amino‐3‐fosfono‐propionico (APPA) (0.6 mM), el acido α‐amino‐fosfono‐caproico (APCA) (0.95) y la hidroxi‐3‐amino‐pirrolidona‐2 (HA966) no produjeron efecto al‐guno. (5) El glutamato no redujo las manifestaciones epilepticas. ZUSAMMENFASSUNG Untersuchung der Wirkungen von Glutamat und Aspartat Antagonisten auf die Frequenz des Lidzuc‐kens und EEG‐Musters bei Ratten, die durch Implantation von Kobalt in den sensomotorischen cerebralen Kortex epileptisch gemacht wurden. (1) α‐Amino‐4‐phosphano Buttersäure (APBA) (0,055‐1.10 mM) verminderte oder behinderte völlig die epileptischen Manifestationen. Die Wirkung war 30 Minuten nach Waschen mit künstlicher Liquorlösung reversibel. (2) DL‐pyroglutamin Säure (DL‐PY) verhinderte völlig myoklonische Zuckungen und EEG‐spikes. (3) Alpha‐amino‐5‐phosphono Valeriansäure (APVA) und α‐D‐amino‐adipic (D‐α‐AA) Säure reduziertendie Häufigkeit epileptischer spikes und myoklonischer Zuckungen signifikant. (4) Andere analoge Substan‐zen. a‐amino‐3‐phosphono Propionsäure (APPA) (0.6 mM), α‐amino‐phosphono‐capronsaure (APCA) (0.95) und Hydroxy‐3‐amino‐pyrrolidon‐2 (HA966) waren wirkungslos. (5) Glutamat selbst vermindert die epileptischen Manifestationen nicht.
Epilepsia – Wiley
Published: Jun 1, 1981
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