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Weimin Li, M. Schuler, M. Berenbaum (2003)
Diversification of furanocoumarin-metabolizing cytochrome P450 monooxygenases in two papilionids: Specificity and substrate encounter rateProceedings of the National Academy of Sciences of the United States of America, 100
Lian-qing Guo, K. Fukuda, T. Ohta, Y. Yamazoe (2000)
Role of furanocoumarin derivatives on grapefruit juice-mediated inhibition of human CYP3A activity.Drug metabolism and disposition: the biological fate of chemicals, 28 7
L. Santana, E. Uriarte, F. Roleira, N. Milhazes, F. Borges (2004)
Furocoumarins in medicinal chemistry. Synthesis, natural occurrence and biological activity.Current medicinal chemistry, 11 24
D. Santos, L. Eriksson (2006)
Permeability of psoralen derivatives in lipid membranes.Biophysical journal, 91 7
J. Manthey, B. Buslig (2005)
Distribution of furanocoumarins in grapefruit juice fractions.Journal of agricultural and food chemistry, 53 13
L. Bezalel, Y. Hadar, C. Cerniglia (1997)
Enzymatic Mechanisms Involved in Phenanthrene Degradation by the White Rot Fungus Pleurotus ostreatusApplied and Environmental Microbiology, 63
H. Bejaoui, F. Mathieu, P. Taillandier, A. Lebrihi (2005)
Conidia of black aspergilli as new biological adsorbents for ochratoxin A in grape juices and musts.Journal of agricultural and food chemistry, 53 21
H. El‐Nezami, N. Polychronaki, S. Salminen, H. Mykkänen (2002)
Binding Rather Than Metabolism May Explain the Interaction of Two Food-Grade Lactobacillus Strains with Zearalenone and Its Derivative ɑ́-ZearalenolApplied and Environmental Microbiology, 68
D. Ringot, Benoit Lerzy, J. Bonhoure, E. Auclair, E. Oriol, Y. Larondelle (2005)
Effect of temperature on in vitro ochratoxin A biosorption onto yeast cell wall derivativesProcess Biochemistry, 40
J. Tatum, R. Berry (1979)
Coumarins and psoralens in grapefruit peel oilPhytochemistry, 18
K. Myung, J. Manthey, J. Narciso (2008)
Aspergillus niger metabolism of citrus furanocoumarin inhibitors of human cytochrome P450 3A4Applied Microbiology and Biotechnology, 78
U. Afek, J. Orenstein, S. Carmeli, V. Rodov, Moshe Joseph (1999)
Umbelliferone, a phytoalexin associated with resistance of immature Marsh grapefruit to Penicillium digitatumPhytochemistry, 50
A. Oliva, Kumudini Meepagala, D. Wedge, D. Harries, A. Hale, G. Aliotta, S. Duke (2003)
Natural fungicides from Ruta graveolens L. leaves, including a new quinolone alkaloid.Journal of agricultural and food chemistry, 51 4
A. Denizli, N. Cihangir, Nalan Tüzmen, Güleren Alsancak (2005)
Removal of chlorophenols from aquatic systems using the dried and dead fungus Pleurotus sajor caju.Bioresource technology, 96 1
(1999)
Fungal metabolism of flavonoids and related phytoalexins
A. Levasseur, D. Navarro, P. Punt, J. Bélaïch, M. Asther, E. Record (2005)
Construction of Engineered Bifunctional Enzymes and Their Overproduction in Aspergillus niger for Improved Enzymatic Tools To Degrade Agricultural By-ProductsApplied and Environmental Microbiology, 71
Saleh El-Sharkawy, Mustafa, I., Selim, Mohamed Afifi, F. Halaweish (1991)
Microbial transformation of zearalenone to a zearalenone sulfateApplied and Environmental Microbiology, 57
S. Mertens-Talcott, I. Zadezensky, W. Castro, H. Derendorf, V. Butterweck (2006)
Grapefruit‐Drug Interactions: Can Interactions With Drugs Be Avoided?The Journal of Clinical Pharmacology, 46
J. Anthey, K. Yung, H. Erendorf, V. Utterweck, W. Ilbur, W. Idmer (2006)
THE ISOLATION OF MINOR-OCCURRING FURANOCOUMARINS IN GRAPEFRUIT AND ANALYSIS OF THEIR INHIBITION OF CYP 3A4 AND P-GLYCOPROTEIN TRANSPORT OF TALINOLOL FROM CACO-2 CELLS
H. Bejaoui, F. Mathieu, P. Taillandier, A. Lebrihi (2004)
Ochratoxin A removal in synthetic and natural grape juices by selected oenological Saccharomyces strainsJournal of Applied Microbiology, 97
M. Paine, W. Widmer, H. Hart, Susan Pusek, K. Beavers, A. Criss, Sherri Brown, B. Thomas, P. Watkins (2006)
A furanocoumarin-free grapefruit juice establishes furanocoumarins as the mediators of the grapefruit juice-felodipine interaction.The American journal of clinical nutrition, 83 5
W. Widmer, C. Haun (2006)
Variation in Furanocoumarin Content and New Furanocoumarin Dimers in Commercial Grapefruit (Citrus paradisi Macf.) JuicesJournal of Food Science, 70
H. Wangensteen, E. Molden, H. Christensen, K. Malterud (2003)
Identification of epoxybergamottin as a CYP3A4 inhibitor in grapefruit peelEuropean Journal of Clinical Pharmacology, 58
J. Maskalyk (2002)
Grapefruit juice: potential drug interactions.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 167 3
Furanocoumarins (FCs) in grapefruit are involved in the “grapefruit/drug interactions” in humans, in which the FCs inhibit the intestinal cytochrome P450 3A4 (CYP 3A4) activity responsible for metabolizing certain prescribed medications. These interactions have adversely affected the grapefruit industry and have led a need to develop a process to remove the FCs from grapefruit juice (GFJ) in a manner that retains much of the original juice sensory attributes. In our experiments, grapefruit juice was incubated with Aspergillus niger, and the compositional changes in hydroxycinnamates, flavonoid glycosides, and the FCs were monitored. Many of the FCs and 7-geranyloxycoumarin were efficiently taken up by the fungal tissue, whereas no uptake occurred with the polar hydroxycinnamates, flavonoid glycosides, and a few of the polar FCs. This biosorption was also observed with autoclaved A. niger, indicating that the uptake of non-polar FCs by the fungal hyphae was due to adsorption rather than metabolism. The binding of the FCs to autoclaved fungus was complete within 4 h, and the level of binding was proportional to the amount of autoclaved fungal hyphae used. This removal of the FCs from GFJ led to a reduced inhibition of CYP 3A4 activity in in vitro assays by both GFJ and GFJ extracts.
Applied Microbiology and Biotechnology – Springer Journals
Published: Jan 10, 2008
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