Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

TTV, a new human virus with single stranded circular DNA genome

TTV, a new human virus with single stranded circular DNA genome TT virus (TTV) was found in 1997 from a hepatitis patient without virus markers. However, the real impact of TTV on liver diseases remains uncertain to date. Due to the lack of suitable cell systems to support the growth of TTV, the biology of TTV is still obscure. This review tries to summarise the current status of TTV on aspects other than the taxonomic diversity of TTV. TTV was the first human virus with a single stranded circular DNA genome. TTV was considered to be a member of Circoviridae, but others suggested it conformed to a new family. TTV is distinct from ambisense viruses in the genus Circovirus, since the former genome is negative stranded. The genome structure of TTV is more related to chicken anaemia virus in the genus Gyrovirus, however, the sequence similarity is minimal except for a short stretch at 3816–3851 of TA278. Currently the working group is proposing the full name for TTV as TorqueTenoVirus and the TTV‐like mini virus as TorqueTenoMiniVirus (TTMV) in a new genus Anellovirus (ring). TTVs are prevalent in non‐human primates and human TTV can cross‐infect chimpanzees. Furthermore, TTV sequences have been detected in chickens, pigs, cows and sheep. TTV can be transmitted by mother‐to‐child infection. However, within a year after birth, the prevalence reaches the same level for children born to both TTV‐positive and TTV‐negative mothers even without breast‐feeding. The non‐coding region surrounding a short 113 nt GC‐rich stretch and occupying approximately one‐third of the genome is considered to contain the putative replication origin. Three mRNAs are expressed by TTV, 3.0 and 1.2 and 1.0 kb species. A protein translated from the 3.0 kb mRNA is considered to be the major capsid protein as well as replicase. The nature of the proteins translated by the other two mRNAs are still putative. Copyright © 2002 John Wiley & Sons, Ltd. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reviews in Medical Virology Wiley

TTV, a new human virus with single stranded circular DNA genome

Reviews in Medical Virology , Volume 12 (3) – May 1, 2002

Loading next page...
 
/lp/wiley/ttv-a-new-human-virus-with-single-stranded-circular-dna-genome-Pet5GJN4ap

References (66)

Publisher
Wiley
Copyright
Copyright © 2002 John Wiley & Sons, Ltd.
ISSN
1052-9276
eISSN
1099-1654
DOI
10.1002/rmv.351
pmid
11987140
Publisher site
See Article on Publisher Site

Abstract

TT virus (TTV) was found in 1997 from a hepatitis patient without virus markers. However, the real impact of TTV on liver diseases remains uncertain to date. Due to the lack of suitable cell systems to support the growth of TTV, the biology of TTV is still obscure. This review tries to summarise the current status of TTV on aspects other than the taxonomic diversity of TTV. TTV was the first human virus with a single stranded circular DNA genome. TTV was considered to be a member of Circoviridae, but others suggested it conformed to a new family. TTV is distinct from ambisense viruses in the genus Circovirus, since the former genome is negative stranded. The genome structure of TTV is more related to chicken anaemia virus in the genus Gyrovirus, however, the sequence similarity is minimal except for a short stretch at 3816–3851 of TA278. Currently the working group is proposing the full name for TTV as TorqueTenoVirus and the TTV‐like mini virus as TorqueTenoMiniVirus (TTMV) in a new genus Anellovirus (ring). TTVs are prevalent in non‐human primates and human TTV can cross‐infect chimpanzees. Furthermore, TTV sequences have been detected in chickens, pigs, cows and sheep. TTV can be transmitted by mother‐to‐child infection. However, within a year after birth, the prevalence reaches the same level for children born to both TTV‐positive and TTV‐negative mothers even without breast‐feeding. The non‐coding region surrounding a short 113 nt GC‐rich stretch and occupying approximately one‐third of the genome is considered to contain the putative replication origin. Three mRNAs are expressed by TTV, 3.0 and 1.2 and 1.0 kb species. A protein translated from the 3.0 kb mRNA is considered to be the major capsid protein as well as replicase. The nature of the proteins translated by the other two mRNAs are still putative. Copyright © 2002 John Wiley & Sons, Ltd.

Journal

Reviews in Medical VirologyWiley

Published: May 1, 2002

There are no references for this article.