Access the full text.
Sign up today, get DeepDyve free for 14 days.
K. Yoshida, G. Blobel (2001)
The Karyopherin Kap142p/Msn5p Mediates Nuclear Import and Nuclear Export of Different Cargo ProteinsThe Journal of Cell Biology, 152
U. Kutay, F. Bischoff, S. Kostka, R. Kraft, D. Görlich (1997)
Export of Importin α from the Nucleus Is Mediated by a Specific Nuclear Transport FactorCell, 90
I. Vetter, A. Arndt, U. Kutay, D. Görlich, A. Wittinghofer (1999)
Structural view of the Ran-Importin beta interaction at 2.3 A resolution.Cell, 97 5
T. Kino, Emanuel Souvatzoglou, M. Martino, Maria Tsopanomihalu, Y. Wan, G. Chrousos (2003)
Protein 14-3-3σ Interacts with and Favors Cytoplasmic Subcellular Localization of the Glucocorticoid Receptor, Acting as a Negative Regulator of the Glucocorticoid Signaling Pathway*Journal of Biological Chemistry, 278
B. Zeitler, K. Weis (2004)
The FG-repeat asymmetry of the nuclear pore complex is dispensable for bulk nucleocytoplasmic transport in vivoThe Journal of Cell Biology, 167
T. Cour, Ramneek Gupta, Kristoffer Rapacki, K. Skriver, F. Poulsen, S. Brunak (2003)
NESbase version 1.0: a database of nuclear export signalsNucleic acids research, 31 1
Y. Chook, Astrid Jung, M. Rosen, G. Blobel (2002)
Uncoupling Kapβ2 Substrate Dissociation and Ran BindingBiochemistry, 41
Brook Pyhtila, M. Rexach (2003)
A Gradient of Affinity for the Karyopherin Kap95p along the Yeast Nuclear Pore Complex*Journal of Biological Chemistry, 278
B. Senger, G. Simos, F. Bischoff, A. Podtelejnikov, M. Mann, E. Hurt (1998)
Mtr10p functions as a nuclear import receptor for the mRNA‐binding protein Npl3pThe EMBO Journal, 17
S. Strunze, L. Trotman, K. Boucke, U. Greber (2005)
Nuclear targeting of adenovirus type 2 requires CRM1-mediated nuclear export.Molecular biology of the cell, 16 6
E. Conti (2002)
Structures of importins.Results and problems in cell differentiation, 35
S. Steggerda, B. Paschal (2000)
The Mammalian Mog1 Protein Is a Guanine Nucleotide Release Factor for Ran*The Journal of Biological Chemistry, 275
Deena Leslie, Wenzhu Zhang, Benjamin Timney, B. Chait, M. Rout, R. Wozniak, J. Aitchison (2004)
Characterization of Karyopherin Cargoes Reveals Unique Mechanisms of Kap121p-Mediated Nuclear ImportMolecular and Cellular Biology, 24
Y. Katagiri, K. Takeda, Zu-Xi Yu, V. Ferrans, K. Ozato, G. Guroff (2000)
Modulation of retinoid signalling through NGF-induced nuclear export of NGFI-BNature Cell Biology, 2
Saporita (2003)
Identification and characterization of a ligand-regulated nuclear export signal in androgen receptorJ Biol Chem, 278
Zhong-xun Zhou, M. Sar, J. Simental, M. Lane, E. Wilson (1994)
A ligand-dependent bipartite nuclear targeting signal in the human androgen receptor. Requirement for the DNA-binding domain and modulation by NH2-terminal and carboxyl-terminal sequences.The Journal of biological chemistry, 269 18
M. Ohtsubo, R. Kai, N. Furuno, T. Sekiguchi, M. Sekiguchi, H. Hayashida, K. Kuma, T. Miyata, S. Fukushige, T. Murotsu, K. Matsubara, Takeharu imoto (1987)
Isolation and characterization of the active cDNA of the human cell cycle gene (RCC1) involved in the regulation of onset of chromosome condensation.Genes & development, 1 6
K. Lux, Nico Goerlitz, Stefanie Schlemminger, L. Perabò, Daniela Goldnau, J. Endell, K. Leike, D. Kofler, S. Finke, M. Hallek, H. Büning (2005)
Green Fluorescent Protein-Tagged Adeno-Associated Virus Particles Allow the Study of Cytosolic and Nuclear TraffickingJournal of Virology, 79
M. Peifer, S. Berg, Ab Reynolds (1994)
A repeating amino acid motif shared by proteins with diverse cellular rolesCell, 76
D. Picard, V. Kumart, Pierre Chambont, K. Yamamoto (1990)
Signal transduction by steroid hormones: nuclear localization is differentially regulated in estrogen and glucocorticoid receptors.Cell regulation, 1 3
D. Görlich, U. Kutay (1999)
Transport between the cell nucleus and the cytoplasm.Annual review of cell and developmental biology, 15
J. Ji, Huiyan Jing, S. Diamond (2003)
Shear Stress Causes Nuclear Localization of Endothelial Glucocorticoid Receptor and Expression From the GRE PromoterCirculation Research: Journal of the American Heart Association, 92
M. Salminen, K. Airenne, Rita Rinnankoski, Jenni Reimari, Outi Välilehto, Johanna Rinne, S. Suikkanen, Sari Kukkonen, S. Ylä-Herttuala, M. Kulomaa, M. Vihinen-Ranta (2005)
Improvement in Nuclear Entry and Transgene Expression of Baculoviruses by Disintegration of Microtubules in Human HepatocytesJournal of Virology, 79
V. Kim (2004)
MicroRNA precursors in motion: exportin-5 mediates their nuclear export.Trends in cell biology, 14 4
K. Stade, C. Ford, C. Guthrie, K. Weis (1997)
Exportin 1 (Crm1p) Is an Essential Nuclear Export FactorCell, 90
W. Wen, Judy Meinkotht, R. Tsien, Susan Taylor (1995)
Identification of a signal for rapid export of proteins from the nucleusCell, 82
M. Fontes, T. Teh, B. Kobe (2000)
Structural basis of recognition of monopartite and bipartite nuclear localization sequences by mammalian importin-alpha.Journal of molecular biology, 297 5
T. Davies, Y. Ning, E. Sánchez (2002)
A New First Step in Activation of Steroid ReceptorsThe Journal of Biological Chemistry, 277
Michelle Harreman, Trisha Kline, Heidi Milford, M. Harben, A. Hodel, A. Corbett (2004)
Regulation of Nuclear Import by Phosphorylation Adjacent to Nuclear Localization Signals*Journal of Biological Chemistry, 279
A., V., Š., M. (2001)
Transcriptional Activation and Nuclear Targeting Signals of the Human Androgen Receptor *
Yan Zeng, B. Cullen (2004)
Structural requirements for pre-microRNA binding and nuclear export by Exportin 5.Nucleic acids research, 32 16
D. Stewart, Anirban Ghosh, G. Matlashewski (2005)
Involvement of Nuclear Export in Human Papillomavirus Type 18 E6-Mediated Ubiquitination and Degradation of p53Journal of Virology, 79
N. Mosammaparast, Kelley Jackson, Yurong Guo, C. Brame, J. Shabanowitz, D. Hunt, L. Pemberton (2001)
Nuclear Import of Histone H2a and H2b Is Mediated by a Network of KaryopherinsThe Journal of Cell Biology, 153
Soo Lee, T. Sekimoto, E. Yamashita, E. Nagoshi, A. Nakagawa, N. Imamoto, M. Yoshimura, H. Sakai, K. Chong, T. Tsukihara, Y. Yoneda (2003)
The Structure of Importin-ß Bound to SREBP-2: Nuclear Import of a Transcription FactorScience, 302
D. Goldfarb, A. Corbett, D. Mason, Michelle Harreman, S. Adam (2004)
Importin alpha: a multipurpose nuclear-transport receptor.Trends in cell biology, 14 9
I. Ben-Efraim, L. Gerace (2001)
Gradient of Increasing Affinity of Importin β for Nucleoporins along the Pathway of Nuclear ImportThe Journal of Cell Biology, 152
Y. Chook, Astrid Jung, M. Rosen, G. Blobel (2002)
Uncoupling Kapbeta2 substrate dissociation and ran binding.Biochemistry, 41 22
M. Andrade, P. Bork (1995)
HEAT repeats in the Huntington's disease proteinNature Genetics, 11
J. Simental, Madhabananda Sar, Malcolm Lane, Frank French, E. Wilson (1991)
Transcriptional activation and nuclear targeting signals of the human androgen receptor.The Journal of biological chemistry, 266 1
J. Liu, D. DeFranco (2000)
Protracted nuclear export of glucocorticoid receptor limits its turnover and does not require the exportin 1/CRM1-directed nuclear export pathway.Molecular endocrinology, 14 1
N. Freedman, K. Yamamoto (2004)
Importin 7 and importin alpha/importin beta are nuclear import receptors for the glucocorticoid receptor.Molecular biology of the cell, 15 5
M. Moore, G. Blobel (1994)
Purification of a Ran-interacting protein that is required for protein import into the nucleus.Proceedings of the National Academy of Sciences of the United States of America, 91 21
Amnon Harel, D. Forbes (2004)
Importin beta: conducting a much larger cellular symphony.Molecular cell, 16 3
D. Gioeli, J. Mandell, G. Petroni, H. Frierson, M. Weber (1999)
Activation of mitogen-activated protein kinase associated with prostate cancer progression.Cancer research, 59 2
Hoi-Yeung Li, Yixian Zheng (2004)
Phosphorylation of RCC1 in mitosis is essential for producing a high RanGTP concentration on chromosomes and for spindle assembly in mammalian cells.Genes & development, 18 5
Y. Chook, G. Blobel (2001)
Karyopherins and nuclear import.Current opinion in structural biology, 11 6
B. Black, B. Paschal (2004)
Intranuclear organization and function of the androgen receptorTrends in Endocrinology & Metabolism, 15
Arie Kaffman, E. O’Shea (1999)
Regulation of nuclear localization: a key to a door.Annual review of cell and developmental biology, 15
E. Lei, P. Silver (2002)
Protein and RNA export from the nucleus.Developmental cell, 2 3
J. Rosenblum, L. Pemberton, N. Bonifaci, G. Blobel (1998)
Nuclear Import and the Evolution of a Multifunctional RNA-binding ProteinThe Journal of Cell Biology, 143
J. Cronshaw, A. Krutchinsky, Wenzhu Zhang, B. Chait, M. Matunis (2002)
Proteomic analysis of the mammalian nuclear pore complexThe Journal of Cell Biology, 158
M. Lindsay, Kendra Plafker, Alicia Smith, B. Clurman, I. Macara (2002)
Npap60/Nup50 is a tri-stable switch that stimulates importin-alpha:beta-mediated nuclear protein import.Cell, 110 3
Pratt (1997)
Steroid receptor interactions with heat shock protein and immunophilin chaperonesEndocr Rev, 18
Liqun Zhang, Mai Johnson, K. Le, Makoto Sato, Romyla Ilagan, M. Iyer, S. Gambhir, Lily Wu, M. Carey (2003)
Interrogating androgen receptor function in recurrent prostate cancer.Cancer research, 63 15
N. Freedman, K. Yamamoto (2004)
Importin 7 and Importin α/Importin β Are Nuclear Import Receptors for the Glucocorticoid ReceptorMolecular Biology of the Cell, 15
M. Qiu, A. Olsen, Emily Faivre, K. Horwitz, C. Lange (2003)
Mitogen-activated protein kinase regulates nuclear association of human progesterone receptors.Molecular endocrinology, 17 4
B. Paschal, L. Gerace (1995)
Identification of NTF2, a cytosolic factor for nuclear import that interacts with nuclear pore complex protein p62The Journal of Cell Biology, 129
Y. Chook, G. Blobel (1999)
Structure of the nuclear transport complex karyopherin-beta2-Ran x GppNHp.Nature, 399 6733
F. Bischoff, Christian KLEBEt, Jürgen Kretschmer, Alfred WITrINGHOFERt, H. Ponstingl (1994)
RanGAP1 induces GTPase activity of nuclear Ras-related Ran.Proceedings of the National Academy of Sciences of the United States of America, 91 7
M. Ohno, A. Segref, A. Bachi, M. Wilm, I. Mattaj (2000)
PHAX, a Mediator of U snRNA Nuclear Export Whose Activity Is Regulated by PhosphorylationCell, 101
(1998)
Importin beta, transportin, RanBP5 and RanBP7 mediate nuclear import of ribosomal proteins in mammalian cells
Alicia Smith, B. Slepchenko, J. Schaff, L. Loew, I. Macara (2002)
Systems Analysis of Ran TransportScience, 295
G. Cingolani, C. Petosa, K. Weis, C. Müller (1999)
Structure of importin-beta bound to the IBB domain of importin-alpha.Nature, 399 6733
M. Oki, T. Nishimoto (1998)
A protein required for nuclear-protein import, Mog1p, directly interacts with GTP-Gsp1p, the Saccharomyces cerevisiae ran homologue.Proceedings of the National Academy of Sciences of the United States of America, 95 26
E. Conti, Marc Uy, L. Leighton, G. Blobel, J. Kuriyan (1998)
Crystallographic Analysis of the Recognition of a Nuclear Localization Signal by the Nuclear Import Factor Karyopherin αCell, 94
G. Arts, S. Kuersten, P. Romby, B. Ehresmann, I. Mattaj (1998)
The role of exportin‐t in selective nuclear export of mature tRNAsThe EMBO Journal, 17
Jerome Cros, A. García-Sastre, P. Palese (2005)
An Unconventional NLS is Critical for the Nuclear Import of the Influenza A Virus Nucleoprotein and RibonucleoproteinTraffic, 6
Hoi-Yeung Li, D. Wirtz, Yixian Zheng (2003)
A mechanism of coupling RCC1 mobility to RanGTP production on the chromatin in vivoThe Journal of Cell Biology, 160
Nobuhiko Yokoyama, N. Hayashi, Tatsuya Seki, N. Panté, T. Ohba, K. Nishii, K. Kuma, T. Hayashida, T. Miyata, U. Aebi, U. Aebi, M. Fukui, T. Nishimoto (1995)
A giant nucleopore protein that binds Ran/TC4Nature, 376
B. Black, James Holaska, F. Rastinejad, B. Paschal (2001)
DNA binding domains in diverse nuclear receptors function as nuclear export signalsCurrent Biology, 11
M. Nemergut, I. Macara (2000)
Nuclear Import of the Ran Exchange Factor, Rcc1, Is Mediated by at Least Two Distinct MechanismsThe Journal of Cell Biology, 149
Bradford Talcott, M. Moore (2000)
The Nuclear Import of RCC1 Requires a Specific Nuclear Localization Sequence Receptor, Karyopherin α3/Qip*The Journal of Biological Chemistry, 275
M. Stewart, Helen Kent, A. Mccoy (1998)
Structural basis for molecular recognition between nuclear transport factor 2 (NTF2) and the GDP-bound form of the Ras-family GTPase Ran.Journal of molecular biology, 277 3
L. Renault, J. Kuhlmann, A. Henkel, A. Wittinghofer (2001)
Structural Basis for Guanine Nucleotide Exchange on Ran by the Regulator of Chromosome Condensation (RCC1)Cell, 105
David Goldfarb, A. Corbett, D. Mason, Michelle Harreman, S. Adam (2004)
Importin α: A multipurpose nuclear-transport receptorTrends in Cell Biology, 14
M. Oki, T. Nishimoto (2000)
Yrb1p Interaction with the Gsp1p C Terminus Blocks Mog1p Stimulation of GTP Release from Gsp1p*The Journal of Biological Chemistry, 275
Taras Makhnevych, C. Lusk, Andrea Anderson, J. Aitchison, R. Wozniak (2003)
Cell Cycle Regulated Transport Controlled by Alterations in the Nuclear Pore ComplexCell, 115
P. Kumar, P. Singhal, M. Rao, S. Mahalingam (2005)
Phosphorylation by MAPK Regulates Simian Immunodeficiency Virus Vpx Protein Nuclear Import and Virus Infectivity*Journal of Biological Chemistry, 280
C. Petosa, G. Schoehn, P. Askjaer, U. Bauer, M. Moulin, U. Steuerwald, M. Soler‐Lopez, F. Baudin, I. Mattaj, C. Müller (2004)
Architecture of CRM1/Exportin1 suggests how cooperativity is achieved during formation of a nuclear export complex.Molecular cell, 16 5
L. Strawn, Tianxiang Shen, N. Shulga, D. Goldfarb, S. Wente (2004)
Minimal nuclear pore complexes define FG repeat domains essential for transportNature Cell Biology, 6
D. Görlich, M. Seewald, K. Ribbeck (2003)
Characterization of Ran‐driven cargo transport and the RanGTPase system by kinetic measurements and computer simulationThe EMBO Journal, 22
T. Ylikomi, M. Bocquel, M. Berry, H. Gronemeyer, P. Chambon (1992)
Cooperation of proto‐signals for nuclear accumulation of estrogen and progesterone receptors.The EMBO Journal, 11
J. Schaley, M. Polonskaia, P. Hearing (2005)
The Adenovirus E4-6/7 Protein Directs Nuclear Localization of E2F-4 via an Arginine-Rich MotifJournal of Virology, 79
Bayliss (2000)
Structural basis for the interaction between FxFG nucleoporin repeats and importin-beta in nuclear traffickingCell, 102
Petra Mühlhäusser, E. Müller, A. Otto, U. Kutay (2001)
Multiple pathways contribute to nuclear import of core histonesEMBO reports, 2
Ulrike Kutay, Gerd Lipowsky, Elisa Izaurralde, F. Bischoff, Petra Schwarzmaier, E. Hartmann, Dirk Görlich (1998)
Identification of a tRNA-specific nuclear export receptor.Molecular cell, 1 3
C. Zheng, R. Brownlie, L. Babiuk, S. Hurk (2005)
Characterization of the Nuclear Localization and Nuclear Export Signals of Bovine Herpesvirus 1 VP22Journal of Virology, 79
M. Lindsay, Kendra Plafker, Alicia Smith, B. Clurman, I. Macara (2002)
Npap60/Nup50 Is a Tri-Stable Switch that Stimulates Importin-α:β-Mediated Nuclear Protein ImportCell, 110
Liu (2000)
Protracted nuclear export of glucocorticoid receptor limits its turnover and does not require the exportin 1/CRM1-directed nuclear export pathwayMol Endocrinol, 14
D. Devos, S. Dokudovskaya, F. Alber, Rosemary Williams, B. Chait, A. Sali, M. Rout (2004)
Components of Coated Vesicles and Nuclear Pore Complexes Share a Common Molecular ArchitecturePLoS Biology, 2
M. Nemergut, C. Mizzen, T. Stukenberg, C. Allis, I. Macara (2001)
Chromatin docking and exchange activity enhancement of RCC1 by histones H2A and H2B.Science, 292 5521
M. Fontes, T. Teh, D. Jans, R. Brinkworth, B. Kobe (2003)
Structural Basis for the Specificity of Bipartite Nuclear Localization Sequence Binding by Importin-α*Journal of Biological Chemistry, 278
G. Cingolani, J. Bednenko, M. Gillespie, L. Gerace (2002)
Molecular basis for the recognition of a nonclassical nuclear localization signal by importin beta.Molecular cell, 10 6
J. Bednenko, G. Cingolani, Larry Gerace (2003)
Importin (cid:2) contains a COOH-terminal nucleoporin binding region important for nuclear transport
W. Pratt, D. Toft (1997)
Steroid receptor interactions with heat shock protein and immunophilin chaperones.Endocrine reviews, 18 3
I. Vetter, A. Arndt, U. Kutay, D. Görlich, A. Wittinghofer (1999)
Structural View of the Ran–Importin β Interaction at 2.3 Å ResolutionCell, 97
J. Cronshaw, M. Matunis (2004)
The nuclear pore complex: disease associations and functional correlationsTrends in Endocrinology & Metabolism, 15
DeFranco (2002)
Navigating steroid hormone receptors through the nuclear compartmentMol Endocrinol, 16
R. Walther, Claudia Lamprecht, A. Ridsdale, Isabelle Groulx, Stephen Lee, Y. Lefebvre, R. Hache (2003)
Nuclear Export of the Glucocorticoid Receptor Is Accelerated by Cell Fusion-dependent Release of Calreticulin*Journal of Biological Chemistry, 278
N. McKenna, B. O’Malley (2002)
Combinatorial Control of Gene Expression by Nuclear Receptors and CoregulatorsCell, 108
M. Lindsay, James Holaska, K. Welch, B. Paschal, I. Macara (2001)
Ran-Binding Protein 3 Is a Cofactor for Crm1-Mediated Nuclear Protein ExportThe Journal of Cell Biology, 153
H. Fried, U. Kutay (2003)
Nucleocytoplasmic transport: taking an inventoryCellular and Molecular Life Sciences CMLS, 60
B. Cullen (2005)
Human immunodeficiency virus: Nuclear RNA export unwoundNature, 433
P. Kalab, K. Weis, R. Heald (2002)
Visualization of a Ran-GTP Gradient in Interphase and Mitotic Xenopus Egg ExtractsScience, 295
Jun Yang, Jimin Liu, D. DeFranco (1997)
Subnuclear Trafficking of Glucocorticoid Receptors In Vitro: Chromatin Recycling and Nuclear ExportThe Journal of Cell Biology, 137
D. DeFranco (2002)
Navigating steroid hormone receptors through the nuclear compartment.Molecular endocrinology, 16 7
U. Fischer, J. Huber, W. Boelens, Lain Mattajt, R. Lührmann (1995)
The HIV-1 Rev Activation Domain is a nuclear export signal that accesses an export pathway used by specific cellular RNAsCell, 82
Didier Picard, Keith Yamamoto (1987)
Two signals mediate hormone‐dependent nuclear localization of the glucocorticoid receptor.The EMBO Journal, 6
Jian Wu, M. Matunis, D. Kraemer, G. Blobel, E. Coutavas (1995)
Nup358, a Cytoplasmically Exposed Nucleoporin with Peptide Repeats, Ran-GTP Binding Sites, Zinc Fingers, a Cyclophilin A Homologous Domain, and a Leucine-rich Region (*)The Journal of Biological Chemistry, 270
J. Savory, Brian Hsu, Ian Laquian, W. Giffin, T. Reich, R. Hache, Y. Lefebvre (1999)
Discrimination between NL1- and NL2-Mediated Nuclear Localization of the Glucocorticoid ReceptorMolecular and Cellular Biology, 19
M. Fornerod, M. Ohno, Minoru Yoshida, I. Mattaj (1997)
CRM1 Is an Export Receptor for Leucine-Rich Nuclear Export SignalsCell, 90
M. Itoh, M. Adachi, H. Yasui, M. Takekawa, Hirotoshi Tanaka, K. Imai (2002)
Nuclear export of glucocorticoid receptor is enhanced by c-Jun N-terminal kinase-mediated phosphorylation.Molecular endocrinology, 16 10
V. Pollard, W. Michael, S. Nakielny, M. Siomi, Fan Wang, G. Dreyfuss (1996)
A Novel Receptor-Mediated Nuclear Protein Import PathwayCell, 86
A. Saporita, Qiuheng Zhang, N. Navai, Z. Dinçer, J. Hahn, Xiaoyan Cai, Zhou Wang (2003)
Identification and characterization of a ligand-regulated nuclear export signal in androgen receptor.The Journal of biological chemistry, 278 43
L. Amazit, Y. Alj, R. Tyagi, A. Chauchereau, H. Loosfelt, C. Pichon, J. Pantel, Emmanuelle Foulon-Guinchard, P. Leclerc, E. Milgrom, A. Guiochon‐Mantel (2003)
Subcellular Localization and Mechanisms of Nucleocytoplasmic Trafficking of Steroid Receptor Coactivator-1*Journal of Biological Chemistry, 278
N. Fukuhara, Elena Fernández, J. Ebert, E. Conti, D. Svergun (2004)
Conformational Variability of Nucleo-cytoplasmic Transport Factors*Journal of Biological Chemistry, 279
E. Conti, J. Kuriyan (2000)
Crystallographic analysis of the specific yet versatile recognition of distinct nuclear localization signals by karyopherin alpha.Structure, 8 3
Alicia Smith, A. Brownawell, I. Macara (1998)
Nuclear import of Ran is mediated by the transport factor NTF2Current Biology, 8
F. Bischoff, Heike Krebber, Elena Smirnova, Weihua Dong, Herwig Ponstingi (1995)
Co‐activation of RanGTPase and inhibition of GTP dissociation by Ran‐GTP binding protein RanBP1.The EMBO Journal, 14
N. Mosammaparast, Courtney Ewart, L. Pemberton (2002)
A role for nucleosome assembly protein 1 in the nuclear transport of histones H2A and H2BThe EMBO Journal, 21
F. Bischoff, H. Ponstingl (1991)
Catalysis of guanine nucleotide exchange on Ran by the mitotic regulator RCC1Nature, 354
R. Ghildyal, A. Ho, K. Wagstaff, M. Dias, C. Barton, P. Jans, P. Bardin, D. Jans (2005)
Nuclear import of the respiratory syncytial virus matrix protein is mediated by importin beta1 independent of importin alpha.Biochemistry, 44 38
E. Izaurralde, U. Kutay, C. Kobbe, I. Mattaj, D. Görlich (1997)
The asymmetric distribution of the constituents of the Ran system is essential for transport into and out of the nucleusThe EMBO Journal, 16
Arlen Johnson, E. Lund, J. Dahlberg (2002)
Nuclear export of ribosomal subunits.Trends in biochemical sciences, 27 11
Arie Kaffman, Nicole Rank, E. O'Neill, Linda Huang, E. O’Shea (1998)
The receptor Msn5 exports the phosphorylated transcription factor Pho4 out of the nucleusNature, 396
M. Rout, J. Aitchison, Adisetyantari Suprapto, Kelly Hjertaas, Yingming Zhao, B. Chait (2000)
The Yeast Nuclear Pore Complex: Composition, Architecture, and Transport MechanismJournal of Cell Biology, 148
K. Weis (2003)
Regulating Access to the Genome Nucleocytoplasmic Transport throughout the Cell CycleCell, 112
James Holaska, B. Black, D. Love, J. Hanover, J. Leszyk, B. Paschal (2001)
Calreticulin Is a Receptor for Nuclear ExportThe Journal of Cell Biology, 152
I. Poon, D. Jans (2005)
Regulation of Nuclear Transport: Central Role in Development and Transformation?Traffic, 6
M. Suntharalingam, S. Wente (2003)
Peering through the pore: nuclear pore complex structure, assembly, and function.Developmental cell, 4 6
Leonard Shank, B. Paschal (2005)
Nuclear transport of steroid hormone receptors.Critical reviews in eukaryotic gene expression, 15 1
Rohit Mahajan, C. Delphin, T. Guan, L. Gerace, F. Melchior (1997)
A Small Ubiquitin-Related Polypeptide Involved in Targeting RanGAP1 to Nuclear Pore Complex Protein RanBP2Cell, 88
M. Matunis, E. Coutavas, G. Blobel (1996)
A novel ubiquitin-like modification modulates the partitioning of the Ran-GTPase-activating protein RanGAP1 between the cytosol and the nuclear pore complexThe Journal of Cell Biology, 135
Y. Chook, G. Blobel (1999)
Structure of the nuclear transport complex karyopherin-β2–Ran˙GppNHpNature, 399
E. Paraskeva, E. Izaurralde, F. Bischoff, J. Huber, U. Kutay, E. Hartmann, R. Lührmann, D. Görlich (1999)
CRM1-mediated Recycling of Snurportin 1 to the CytoplasmThe Journal of Cell Biology, 145
K. Ribbeck, G. Lipowsky, H. Kent, M. Stewart, D. Görlich (1998)
NTF2 mediates nuclear import of RanThe EMBO Journal, 17
Sundeep Shah, S. Tugendreich, D. Forbes (1998)
Major Binding Sites for the Nuclear Import Receptor Are the Internal Nucleoporin Nup153 and the Adjacent Nuclear Filament Protein TprThe Journal of Cell Biology, 141
R. Bayliss, Sara Leung, R. Baker, B. Quimby, A. Corbett, M. Stewart (2002)
Structural basis for the interaction between NTF2 and nucleoporin FxFG repeatsThe EMBO Journal, 21
Y. Matsuura, M. Stewart (2004)
Structural basis for the assembly of a nuclear export complexNature, 432
H. Granzow, B. Klupp, T. Mettenleiter (2005)
Entry of Pseudorabies Virus: an Immunogold-Labeling StudyJournal of Virology, 79
H. Poukka, U. Karvonen, N. Yoshikawa, Hirotoshi Tanaka, J. Palvimo, Olli Jänne (2000)
The RING finger protein SNURF modulates nuclear trafficking of the androgen receptor.Journal of cell science, 113 ( Pt 17)
Christine Weirich, J. Erzberger, J. Berger, K. Weis (2004)
The N-terminal domain of Nup159 forms a beta-propeller that functions in mRNA export by tethering the helicase Dbp5 to the nuclear pore.Molecular cell, 16 5
B. Kobe (1999)
Autoinhibition by an internal nuclear localization signal revealed by the crystal structure of mammalian importin αNature Structural Biology, 6
K. Prüfer, J. Bársony (2002)
Retinoid X receptor dominates the nuclear import and export of the unliganded vitamin D receptor.Molecular endocrinology, 16 8
Harel (2004)
Importin Beta; conducting a much larger cellular symphonyMol Cell, 16
N. Mosammaparast, L. Pemberton (2004)
Karyopherins: from nuclear-transport mediators to nuclear-function regulators.Trends in cell biology, 14 10
Nuclear transport of proteins and RNA occurs through the nuclear pore complex and is mediated by a superfamily of transport receptors known collectively as karyopherins. Karyopherins bind to their cargoes by recognition of specific nuclear localization signals or nuclear export signals. Transport through the nuclear pore complex is facilitated by transient interactions between the karyopherins and the nuclear pore complex. The interactions of karyopherins with their cargoes are regulated by the Ras‐related GTPase Ran. Ran is assisted in this process by proteins that regulate its GTPase cycle and subcellular localization. In this review, we describe several of the major transport pathways that are conserved in higher and lower eukaryotes, with particular emphasis on the role of Ran. We highlight the latest advances in the structure and function of transport receptors and discuss recent examples of steroid hormone receptor import and regulation by signal transduction pathways. Understanding the molecular basis of nuclear transport may provide insight into human diseases by revealing how nucleocytoplasmic trafficking regulates protein activity.
Traffic – Wiley
Published: Mar 1, 2005
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.