Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

The Effect of Metformin on Glycaemic Control, Intermediary Metabolism and Blood Pressure in Non‐insulin‐dependent Diabetes Mellitus

The Effect of Metformin on Glycaemic Control, Intermediary Metabolism and Blood Pressure in... Fourteen non‐insulin‐dependent diabetics (9 female, 5 male), aged 46 to 64 years, uncontrolled by diet (fasting plasma glucose ≥8 mmol/l), were treated with metformin, 1–3 g daily, and followed prospectively at 1 week, then at 2‐weekly intervals for 6 months. The fasting plasma glucose fell significantly (p<0.01) after 1 week of therapy and HbA1 showed a significant reduction, 13.4 ± 2.5% (mean ±SD) to 10.7 ± 1.8% (normal range 5.1–9.3%) at 8 weeks (p<0.001). There was no significant change in body weight, plasma insulin, serum cholesterol or triglycerides, blood lactate, pyruvate, glycerol, alanine, 3‐hydroxybutyrate or acetoacetate concentrations. Systolic, diastolic, and mean arterial blood pressures, along with resting heart rate remained unchanged. This study shows that metformin effectively lowers plasma glucose without hyperinsulinism or significant rise in fasting blood lactate and other gluconeogenic precursors. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Diabetic Medicine Wiley

The Effect of Metformin on Glycaemic Control, Intermediary Metabolism and Blood Pressure in Non‐insulin‐dependent Diabetes Mellitus

Download PDF
5 pages

Loading next page...
 
/lp/wiley/the-effect-of-metformin-on-glycaemic-control-intermediary-metabolism-PN0huA1MaM

References (27)

Publisher
Wiley
Copyright
1987 Diabetes UK
ISSN
0742-3071
eISSN
1464-5491
DOI
10.1111/j.1464-5491.1987.tb00895.x
Publisher site
See Article on Publisher Site

Abstract

Fourteen non‐insulin‐dependent diabetics (9 female, 5 male), aged 46 to 64 years, uncontrolled by diet (fasting plasma glucose ≥8 mmol/l), were treated with metformin, 1–3 g daily, and followed prospectively at 1 week, then at 2‐weekly intervals for 6 months. The fasting plasma glucose fell significantly (p<0.01) after 1 week of therapy and HbA1 showed a significant reduction, 13.4 ± 2.5% (mean ±SD) to 10.7 ± 1.8% (normal range 5.1–9.3%) at 8 weeks (p<0.001). There was no significant change in body weight, plasma insulin, serum cholesterol or triglycerides, blood lactate, pyruvate, glycerol, alanine, 3‐hydroxybutyrate or acetoacetate concentrations. Systolic, diastolic, and mean arterial blood pressures, along with resting heart rate remained unchanged. This study shows that metformin effectively lowers plasma glucose without hyperinsulinism or significant rise in fasting blood lactate and other gluconeogenic precursors.

Journal

Diabetic Medicine – Wiley

Published: Jul 8, 1987

There are no references for this article.