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Effect of Fish Oil on Heart Rate in Humans A Meta-Analysis of Randomized Controlled Trials

Effect of Fish Oil on Heart Rate in Humans A Meta-Analysis of Randomized Controlled Trials Effect of Fish Oil on Heart Rate in Humans A Meta-Analysis of Randomized Controlled Trials Dariush Mozaffarian, MD, MPH; Anouk Geelen, PhD; Ingeborg A. Brouwer, PhD; Johanna M. Geleijnse, PhD; Peter L. Zock, PhD; Martijn B. Katan, PhD Background—The effect of fish oil on heart rate (HR), a major risk factor for sudden death, is not well established. We calculated this effect in a meta-analysis of randomized, double-blind, placebo-controlled trials in humans. Methods and Results—Randomized trials of fish oil that evaluated HR were identified through MEDLINE (1966 through January 2005), hand-searching of references, and contact with investigators for unpublished results. Two investigators independently extracted trial data. A pooled estimate was calculated from random-effects meta-analysis. Predefined stratified meta-analyses and meta-regression were used to explore potential heterogeneity. Of 197 identified articles, 30 met inclusion criteria. Evidence for publication bias was not present. In the overall pooled estimate, fish oil decreased HR by 1.6 bpm (95% CI, 0.6 to 2.5; P0.002) compared with placebo. Between-trial heterogeneity was evident (Q test, P0.001). Fish oil reduced HR by 2.5 bpm (P0.001) in trials with baseline HR 69 bpm (median) but had little effect (0.04-bpm reduction; P0.56) in trials with baseline HR 69 bpm (P http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Circulation Wolters Kluwer Health

Effect of Fish Oil on Heart Rate in Humans A Meta-Analysis of Randomized Controlled Trials

Katan, Martijn B.
Circulation , Volume 112 (13) – Sep 1, 2005
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References (64)

ISSN
0009-7322
eISSN
1524-4539
DOI
10.1161/CIRCULATIONAHA.105.556886
pmid
16172267
Publisher site
See Article on Publisher Site

Abstract

Effect of Fish Oil on Heart Rate in Humans A Meta-Analysis of Randomized Controlled Trials Dariush Mozaffarian, MD, MPH; Anouk Geelen, PhD; Ingeborg A. Brouwer, PhD; Johanna M. Geleijnse, PhD; Peter L. Zock, PhD; Martijn B. Katan, PhD Background—The effect of fish oil on heart rate (HR), a major risk factor for sudden death, is not well established. We calculated this effect in a meta-analysis of randomized, double-blind, placebo-controlled trials in humans. Methods and Results—Randomized trials of fish oil that evaluated HR were identified through MEDLINE (1966 through January 2005), hand-searching of references, and contact with investigators for unpublished results. Two investigators independently extracted trial data. A pooled estimate was calculated from random-effects meta-analysis. Predefined stratified meta-analyses and meta-regression were used to explore potential heterogeneity. Of 197 identified articles, 30 met inclusion criteria. Evidence for publication bias was not present. In the overall pooled estimate, fish oil decreased HR by 1.6 bpm (95% CI, 0.6 to 2.5; P0.002) compared with placebo. Between-trial heterogeneity was evident (Q test, P0.001). Fish oil reduced HR by 2.5 bpm (P0.001) in trials with baseline HR 69 bpm (median) but had little effect (0.04-bpm reduction; P0.56) in trials with baseline HR 69 bpm (P

Journal

Circulation – Wolters Kluwer Health

Published: Sep 1, 2005

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