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E. Hersh, G. Bodey, Boyd Nies, E. Freireich (1965)
CAUSES OF DEATH IN ACUTE LEUKEMIA: A TEN-YEAR STUDY OF 414 PATIENTS FROM 1954-1963.JAMA, 193
Hersh Hersh, Bodey Bodey, Nies Nies, Freireich Freireich (1965)
Causes of death in acute leukemia. A ten‐year study of 414 patientsJ.A.M.A., 193
A. Kliman, A. Kliman, P. Carbone, Lawrence Gaydos, E. Freireich (1964)
EFFECTS OF INTENSIVE PLASMAPHERESIS ON NORMAL BLOOD DONORS.Blood, 23
The effect of splenectomy on the response to platelet transfusion in patients with aplastic anemia
R. Levin, J. Pert, E. Freireich (1965)
Response to Transfusion of Platelets Pooled from Multiple Donors and the Effects of Various Technics of Concentrating PlateletsTransfusion, 5
F. Flatow, F. Flatow, E. Freireich, E. Freireich (1966)
The increased effectiveness of platelet concentrates prepared in acidified plasma.Blood, 27 4
Freireich Freireich, Schmidt Schmidt, Schneiderman Schneiderman, Frei Frei (1959)
A controlled comparative study of the effect of fresh and preserved whole blood transfusions on bleeding in patients with acute leukemiaNew Eng. J. Med., 260
L. Gaydos, E. Freireich, N. Mantel (1962)
The quantitative relation between platelet count and hemorrhage in patients with acute leukemia.The New England journal of medicine, 266
E. Freireich, A. Kliman, L. Gaydos, N. Mantel, E. Frei (1963)
RESPONSE TO REPEATED PLATELET TRANSFUSION FROM THE SAME DONOR.Annals of internal medicine, 59
(1959)
Use of Platelet Transfusions in Hemorrhage Disease
E. Freireich, P. Schmidt, M. Schneiderman, E. Frei (1959)
A comparative study of the effect of transfusion of fresh and preserved whole blood on bleeding in patients with acute leukemia.The New England journal of medicine, 260 1
Preparation and transfusion of platelet concentrates employing adenosine diphosphate
R. Aster, J. Jandl (1964)
PLATELET SEQUESTRATION IN MAN. II. IMMUNOLOGICAL AND CLINICAL STUDIES.The Journal of clinical investigation, 43
George Brecher, Marvin Schneiderman, Eugene Cronkite (1953)
The reproducibility and constancy of the platelet count.American journal of clinical pathology, 23 1
R. Aster, R. Levin, Harvey Cooper, E. Freireich (1964)
Complement‐Fixing Platelet Iso‐Antibodies in Serum of Transfused Persons. Correlation of Antibodies with Platelet Survival in Thrombocytopenic PatientsTransfusion, 4
R. Levin, E. Freireich, W. Chappell (1964)
Effect of Storage up to 48 Hours on Response to Transfusions of Platelet Rich PlasmaTransfusion, 4
Hemorrhage resulting from thrombocytopenia in patients with acute leukemia and aplastic anemia can be controlled by platelet transfusions. Severe gross hemorrhage was rarely observed when platelet counts were higher than 20,000 per cu. mm. Transfusion of 1 × 1011 platelets produced an average increment of 12–14,000 platelets per cu. mm./square meter (m2) of body surface in acute leukemia. One unit of platelet rich plasma (PRP) contains an average of 1 × 1011 platelets and 4 PRP/m2 twice weekly will maintain the platelets above 20,000 per cu. mm. most of the time. When very large doses of platelets are required in a small volume then platelet concentrates (PC), prepared by centrifuging PRP and removing most of the plasma, are used. PC are 80 to 90 per cent as effective as PRP in elevating the platelet count if prepared from plasma with a pH of 6.8 or less, achieved by the addition of citric acid. The major hazard of platelet transfusion is posttransfusion hepatitis. This can be minimized by the use of plasmapheresis thus using the same donors repeatedly. In the presence of anemia platelets can be given effectively in fresh whole blood transfusions until the patient's hematocrit is raised.
Transfusion – Wiley
Published: Jan 2, 1966
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