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T. Yanagihara (1973)
Cerebral Anoxia: An Improved In Vitro Model for Biochemical StudyStroke, 4
S. Yap, R. Spector (1965)
Cerebral protein synthesis in anoxic-ischaemic brain injury in the rat.The Journal of pathology and bacteriology, 90 2
(1966)
Srrokc 3.773-73% YANAFIHARA T. ( 1 9 7 3 ~ ) Srruke
& T I I A~Z I I A I $1 K s. 1. IIYJ5I ./ / l J , l / . ( ' / I < v I I . 161
B. Mcewen, L. Plapinger, G. Wallach, C. Magnus (1972)
PROPERTIES OF CELL NUCLEI ISOLATED FROM VARIOUS REGIONS OF RAT BRAIN: DIVERGENT CHARACTERISTICS OF CEREBELLAR CELL NUCLEIJournal of Neurochemistry, 19
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A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid.The Biochemical journal, 62 2
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IN VITRO RNA SYNTHESES BY INTACT RAT BRAIN NUCLEI 1Journal of Neurochemistry, 15
T. Yanagihara, A. Hamberger (1971)
Effect of diphenylhydantoin on protein metabolism in the central nervous system. Study of subcellular fractions.Experimental neurology, 31 1
P. Kleihues, K. Hossmann (1971)
Protein synthesis in the cat brain after prolonged cerebral ischemia.Brain research, 35 2
H. Lovtrup-rein, B. McEwen (1966)
ISOLATION AND FRACTIONATION OF RAT BRAIN NUCLEIThe Journal of Cell Biology, 30
T. Yanagihara (1972)
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T. Johnson, G. Belytschko (1969)
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(1973)
Abstracr, 4rh mering of rhe Interriotiond Socic,ri-for Nrurochrinivtr-v
Abstract— The activity of DNA‐dependent RNA polymerase and the synthesis of microsomal protein were investigated after various periods of anoxic condition produced with rabbit brain in an in vitro experimental model. There was prompt inhibition of protein synthesis even after an anoxic period of 5 min, and inhibition was more than 80 per cent after an anoxic period of 30 min. However, RNA polymerase activity was retained during the early stage of anoxia, but definite inhibition appeared after an anoxic period of 15 min. Comparisons with other available information suggest that the inhibition of protein synthesis observed with brain slices is closely related to their polysomal function, that irreversibility of inhibition of protein synthesis might be related to the involvement of nuclear RNA synthesizing mechanism, and that these can occur both in the neuronal and glial elements.
Journal of Neurochemistry – Wiley
Published: Jan 1, 1974
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