Access the full text.
Sign up today, get DeepDyve free for 14 days.
M. Kuhar (1986)
Neuroanatomical substrates of anxiety: a brief surveyTrends in Neurosciences, 9
S. Lundin, P. Friberg, S. Ricksten (1983)
Diastolic properties of the hypertrophied left ventricle in spontaneously hypertensive rats.Acta physiologica Scandinavica, 118 1
Duncan Taylor, L. Riblet, H. Stanton, A. Eison, D. Temple (1982)
Dopamine and antianxiety activityPharmacology Biochemistry and Behavior, 17
D. Clark, S. Hjorth, A. Carlsson (1984)
(+)- and (-)-3-PPP exhibit different intrinsic activity at striatal dopamine autoreceptors controlling dopamine synthesis.European journal of pharmacology, 106 1
J. Reinhard, M. Bannon, R. Roth (1982)
Acceleration by stress of dopamine synthesis and metabolism in prefrontal cortex: Antagonism by diazepamNaunyn-Schmiedeberg's Archives of Pharmacology, 318
(1985)
peated testing of rats markedly enhances the duration of haloperidol - induced effects on treadmill locomotion and on catalep
M. Bannon, R. Michaud, R. Roth (1981)
Mesocortical dopamine neurons. Lack of autoreceptors modulating dopamine synthesis.Molecular pharmacology, 19 2
N. Andén, M. Grabowska‐Andén, S. Lindgren, U. Thornström (1983)
Synthesis rate of dopamine: Difference between corpus striatum and limbic system as a possible explanation of variations in reactions to drugsNaunyn-Schmiedeberg's Archives of Pharmacology, 323
D. Clark, A. Carlsson, S. Hjorth, J. Engel, P. Lindberg (2004)
The effect of the enantiomers of 3-PPP on conditioned avoidance responding in the ratPsychopharmacology, 81
D. Clark, S. Hjorth, A. Carlsson (2005)
Dopamine-receptor agonists: Mechanisms underlying autoreceptor selectivityJournal of Neural Transmission, 62
S. Lavielle, J. Tassin, A. Thierry, G. Blanc, D. Hervé, C. Barthélémy, J. Glowinski (1979)
Blockade by benzodiazepines of the selective high increase in dopamine turnover induced by stress in mesocortical dopaminergic neurons of the ratBrain Research, 168
M. Galloway, M. Wolf, R. Roth (1986)
Regulation of dopamine synthesis in the medial prefrontal cortex is mediated by release modulating autoreceptors: studies in vivo.The Journal of pharmacology and experimental therapeutics, 236 3
S. Hjorth (1983)
On the mode of action of 3-(3-hydroxyphenyl)-N-n-propylpiperidine, 3-PPP, and its enantiomers. With particular reference to dopaminergic mechanisms in the central nervous system.Acta physiologica Scandinavica. Supplementum, 517
D. Clark, S. Hjorth, A. Carlsson (2005)
Dopamine receptor agonists: Mechanisms underlying autoreceptor selectivity II. Theoretical considerationsJournal of Neural Transmission, 62
J. Engel, S. Hjorth, K. Svensson, A. Carlsson, S. Liljequist (1984)
Anticonflict effect of the putative serotonin receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT).European journal of pharmacology, 105 3-4
M. Bannon, R. Roth (1983)
Pharmacology of mesocortical dopamine neurons.Pharmacological reviews, 35 1
(1971)
A simple and reliable conflict procedure for testing antianxiety agents
S. Hjorth, J. Engel, A. Carlsson (1986)
Anticonflict effects of low doses of the dopamine agonist apomorphine in the ratPharmacology Biochemistry and Behavior, 24
(1986)
Dopamine auto - receptors modulate dopamine release from the prefrontal cor
S. Liljequist, J. Engel (1984)
The effects of GABA and benzodiazepine receptor antagonists on the anti-conflict actions of diazepam or ethanolPharmacology Biochemistry and Behavior, 21
S. Hjorth, A. Carlsson, D. Clark, Kjell Svensson, H. Wikström, D. Sanchez, P. Lindberg, U. Hacksell, L. Arvidsson, A. Johansson, J. Nilsson (2004)
Central dopamine receptor agonist and antagonist actions of the enantiomers of 3-PPPPsychopharmacology, 81
(1985)
Effects of 3 - PPP enantiomers , SKF - 38393 , and 8 - OH - DPAT on synthesis in mesocortical dopamine neurons
(1985)
Repeated testing of rats markedly enhances the duration of haloperidol-induced effects on treadmill locomotion and on catalepsy
N. And�n, M. Grabowska-And�n, B. Liljenberg (2005)
Demonstration of autoreceptors on dopamine neurons in different brain regions of rats treated with gammabutyrolactoneJournal of Neural Transmission, 58
(1983)
On the mode of action of 3-(3-hydroxyphenyl)-Nn-propylpiperidine, 3-PPP and its enantiomers
G. Gárdos, J. Cole (1980)
Problems in the Assessment of Tardive Dyskinesia
A. Carlsson (2005)
Dopamine receptor agonists: Intrinsic activity vs. state of receptorJournal of Neural Transmission, 57
Reiza Talmaciu, I. Hoffmann, L. Cubeddu (1986)
Dopamine Autoreceptors Modulate Dopamine Release from the Prefrontal CortexJournal of Neurochemistry, 47
J. Vogel, B. Beer, D. Clody (2004)
A simple and reliable conflict procedure for testing anti-anxiety agentsPsychopharmacologia, 21
A. Deutch, S. Tam, R. Roth (1985)
Footshock and conditioned stress increase 3, 4-dihydroxyphenylacetic acid (DOPAC) in the ventral tegmental area but not substantia nigraBrain Research, 333
I. Ferrer, E. Johnstone, T. Crow (1984)
Clinical Effects of Apomorphine in SchizophreniaBritish Journal of Psychiatry, 144
J. Arnt, K. Bogeso, Anne Christensen, John Hyttel, Jens-Jørgen Larsen, O. Svendsen (2004)
Dopamine receptor agonistic and antagonistic effects of 3-PPP enantiomersPsychopharmacology, 81
V. Hillegaart, S. Ahlénius, O. Magnusson, C. Fowler (1987)
Repeated testing of rats markedly enhances the duration of effects induced by haloperidol on treadmill locomotion, catalepsy, and a conditioned avoidance responsePharmacology Biochemistry and Behavior, 27
Francis White, Rex Wang (1984)
A10 dopamine neurons: role of autoreceptors in determining firing rate and sensitivity to dopamine agonists.Life sciences, 34 12
J. Häggström, Lars Gunne, A. Carlsson, H. Wikström (2005)
Antidyskinetic action of 3-PPP, a selective dopaminergic autoreceptor agonist, in Cebus monkeys with persistent neuroleptic-induced dyskinesiasJournal of Neural Transmission, 58
(1985)
Effects of 3-PPP enantiomers, SKF38393, and 8-OH-DPAT on synthesis in mesocortical dopamine
M. Wolf, M. Galloway, R. Roth (1986)
Regulation of dopamine synthesis in the medial prefrontal cortex: studies in brain slices.The Journal of pharmacology and experimental therapeutics, 236 3
L. Chiodo, M. Bannon, A. Grace, R. Roth, B. Bunney (1984)
Evidence for the absence of impulse-regulating somatodendritic and synthesis-modulating nerve terminal autoreceptors on subpopulations of mesocortical dopamine neuronsNeuroscience, 12
213 92 92 3 3 S. Hjorth A. Carlsson J. A. Engel Department of Pharmacology University of Göteborg P.O. Box 33031 S-40033 Göteborg Sweden Abstract The effect of the (+)- and (-)-enantiomers of 3-PPP (conventional and atypical dopamine (DA)-receptor active agent, respectively) were investigated in a commonly used animal model of anxiety: the Vogel licking-conflict test. Low doses (≤0.5 mg/kg SC) of both 3-PPP enantiomers resulted in anti-conflict (=anxiolytic-like) actions in this test. (-)-3-PPP proved to be almost as potent as apomorphine in releasing the punished responding (minimum effective doses; (-)-3-PPP: 0.016, and apomorphine: 0.006 mg/kg SC), whereas (+)-3-PPP was about 10 times less effective than apomorphine. In the higher dose range (≥1.0 mg/kg), both 3-PPP enantiomers instead induced an apparent “pro”-conflict effect; i.e. decreased responding to a level significantly below baseline, thus resulting in a biphasic dose-response curve. Simple alterations in the animals' motivation to drink, in shock threshold or in motor capabilities did not seem to be major explanatory factors either for the anti- or for the “pro”-conflict effects. With regard to the latter, the possibility is discussed of an interaction between the experimental test situation and non conflict-related effects of the drugs, thus interfering with the punished drinking. The findings are interpreted within the concept that low doses of the 3-PPP enantiomers, in particular (-)-3-PPP, may attenuate anxiety-elicited increases in the neurotransmission in certain meso-cortical/limbic DA pathways, i.e. consistent with the previously shown preferentially “limbic” net antidopaminergic profile of action of (-)-3-PPP. The results support an active role for DA in conditions associated with anxiety and reinforce the view that novel putative anxiolytics might be found among selective DA-modulating agents like, e.g. the atypical DA receptor agonist (-)-3-PPP.
Psychopharmacology – Springer Journals
Published: Jul 1, 1987
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.