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M. Alter (1993)
The detection, transmission, and outcome of hepatitis C virus infection.Infectious agents and disease, 2 3
MMWR Morb Mortal Wkly Rep, 30
Detection of hepatitis B viral sequences in early HBVinfection ( abstract )
Jin‐Town Wang, Teh‐Hong Wang, J. Sheu, L. Shih, Jaw-Town Lin, Ding‐Shinn Chen (1991)
Detection of hepatitis B virus DNA by polymerase chain reaction in plasma of volunteer blood donors negative for hepatitis B surface antigen.The Journal of infectious diseases, 163 2
(1995)
Projected yield of screening blood donors for HIV , HBV and HCV nucleic acids to increase blood safety . Retrovirus Epidemiology Donor Study ( abstract )
AuBuchon AuBuchon, Birkmeyer Birkmeyer, Busch Busch (1995)
Cost‐effectiveness of expanded HIV test protocols for donated blood (abstract)Transfusion, 35
V. Thiers, D. Kremsdorf, Huub Schellekens, A. Goudeau, John Sninsky, E. Nakajima, D. Mack, F. Driss, J. Wands, P. Tiollais, C. Bréchot (1988)
TRANSMISSION OF HEPATITIS B FROM HEPATITIS-B-SERONEGATIVE SUBJECTSThe Lancet, 332
Ronald 0. Gilcher, MD, President and Chief Executive Officer
(1990)
Protection against viral hepatitis. Recommendations of the Immunization Practices Advisory Committee (ACIP).MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports, 39 RR-2
Larry Mimms, J. Mosley, Hollinger Fb, R. Aach, C. Stevens, M. Cunningham, D. Vallari, L. Barbosa, George Nemo (1993)
Effect of concurrent acute infection with hepatitis C virus on acute hepatitis B virus infection.British Medical Journal, 307
M. Alter, A. Mareş, S. Hadler, J. Maynard (1987)
The effect of underreporting on the apparent incidence and epidemiology of acute viral hepatitis.American journal of epidemiology, 125 1
(1973)
Antibody responses inviral hepatitis , type B
J. Korelitz, M. Busch, A. Williams (1996)
Antigen testing for human immunodeficiency virus (HIV) and the magnet effect: will the benefit of a new HIV test be offset by the numbers of higher risk, test‐seeking donors attracted to blood centers? Retrovirus Epidemiology Donor StudyTransfusion, 36
R. Dodd (1995)
Transfusion-transmitted hepatitis virus infection.Hematology/oncology clinics of North America, 9 1
(1971)
Acquisition of hepatitis - associated antigen . Clinical features in youngadults
(1997)
DSc, Principal Investigator, Westat, Inc
(1991)
Non-A, non-B hepatitis: impact of the emergence of the hepatitis Cvirus
Serologic responses in HB
M. Lai, P. Farci, A. Figus, A. Balestrieri, M. Arnone, G. Vyas (1989)
Hepatitis B virus DNA in the serum of Sardinian blood donors negative for the hepatitis B surface antigen.Blood, 73 1
MMWR Morb Mortal Wkly Rep, 40
G. Schreiber, M. Busch, S. Kleinman, J. Korelitz (1996)
The Risk of Transfusion-Transmitted Viral InfectionsThe New England Journal of Medicine, 334
M. Busch, J. Korelitz, S. Kleinman, S.R. Lee, J. AuBuchon, G. Schreiber (1995)
Declining value of alanine aminotransferase in screening of blood donors to prevent posttransfusion hepatitis B and C virus infection. The Retrovirus Epidemiology Donor StudyTransfusion, 35
Donahue Donahue, Muñoz Muñoz, Ness Ness (1992)
The declining risk of post‐transfusion hepatitis C virus infectionN Engl J Med, 327
(1995)
Decreased specificity of HBsAg confirmation as a result of decreased specificity of screening test (abstract)
MMWR Morb Mortal Wkly Rep, 40
P. Lelie, H. Cuypers, H. Reesink, C. Poel, I. Winkel, E. Bakker, P. Exel‐Oehlers, D. Vallari, J. Allain, Larry Minims (1992)
Patterns of serological markers in transfusion‐transmitted hepatitis C virus infection using second‐generation HCV assaysJournal of Medical Virology, 37
P. Ulrich, R. Bhat, B. Seto, D. Mack, J. Sninsky, G. Vyas (1989)
Enzymatic amplification of hepatitis B virus DNA in serum compared with infectivity testing in chimpanzees.The Journal of infectious diseases, 160 1
M. Alter, H. Margolis, K. Krawczyński, F. Judson, A. Mares, W. Alexander, Pindiga Hu, Joan Miller, M. Gerber, R. Sampliner, Emory Meeks, M. Beach (1992)
The natural history of community-acquired hepatitis C in the United States. The Sentinel Counties Chronic non-A, non-B Hepatitis Study Team.The New England journal of medicine, 327 27
(1995)
Cost-effectiveness of expanded HIV test protocols for donated blood (abstract). Transfusion
M. Alter, S. Hadler, H. Margolis, W. Alexander, P. Hu, F. Judson, A. Mares, J. Miller, L. Moyer (1990)
The changing epidemiology of hepatitis B in the United States. Need for alternative vaccination strategies.JAMA, 263 9
PhD, Senior Study Director, Westat, Inc., 1650 Research Blvd
R. Dodd (1989)
Screening for hepatitis infectivity among blood donors. A model for blood safety?Archives of pathology & laboratory medicine, 113 3
C. Pao, D. Yao, C. Lin, S. Kao, K. Tsao, C. Sun, Y. Liaw (1991)
Serum hepatitis B virus DNA in hepatitis B virus seropositive and seronegative patients with normal liver function.American journal of clinical pathology, 95 4
T. Zuck, R. Thomson, G. Schreiber, R. Gilcher, S. Kleinman, E. Murphy, H. Ownby, A.E. Williams, M. Busch, J.W. Smith, C. Nass, C. Hollingsworth, G. Nemo (1995)
The Retrovirus Epidemiology Donor Study (REDS): rationale and methodsTransfusion, 35
M. Alter (1993)
Community acquired viral hepatitis B and C in the United States.Gut, 34 2 Suppl
Hoofnagle Hoofnagle, Gerety Gerety, Barker Barker (1975)
Antibody to hepatitis B core antigenAm J Med Sci, 270
M. Alter, E. Mast (1994)
The epidemiology of viral hepatitis in the United States.Gastroenterology clinics of North America, 23 3
(1994)
Summary ofnotifiable diseases , United States 1993
J. Hoofnagle, R. Gerety, Lou Ni, L. Barker (1974)
Antibody to hepatitis B core antigen. A sensitive indicator of hepatitis B virus replication.The New England Journal of Medicine, 290
G. Vyas, S. Cohen, R. Schmid (1978)
Viral hepatitis : a contemporary assessment of etiology, epidemiology, pathogenesis, and prevention : proceedings of the Second Symposium on Viral Hepatitis, University of California, San Francisco, March 16-19, 1978
Masahiko Sugitani, Genevieve Inchauspe, A. Prince, M. Shindo (1992)
Sensitivity of serological assays to identify blood donors with hepatitis C viraemiaThe Lancet, 339
BACKGROUND: Calculations of the incidence of hepatitis B virus (HBV) infections in the blood donor setting that are based solely on data for seroconversion to hepatitis B surface antigen (HBsAg) will underestimate the incidence due to the transient nature of antigenemia. Estimates based on antibody to hepatitis B core antigen will overestimate the incidence due to false‐positive results caused by the nonspecificity of the test. STUDY DESIGN AND METHODS: Serologic test results were obtained from multiple‐time volunteer donors at five United States blood centers from January 1991 through December 1993. The observed HBsAg seroconversion rate was multiplied by an adjustment factor, derived from the weighted average probability of a positive HBsAg test for HBV‐infected donors who become chronic carriers, for donors with a primary antibody response without detectable antigenemia, and for donors who develop transient antigenemia. RESULTS: Among 586,507 multiple‐time donors giving 2,318,356 donations and observed for 822,426 person‐years, the HBsAg incidence rate was 4.01 per 100,000 person‐years. On the basis of prior reports of the duration of HBsAg positivity and the observed distribution of interdonation intervals among the study group, there was an estimated 53‐percent chance that an HBV‐infected donor with transient antigenemia would have a positive HBsAg test result. If 70 percent of newly HBV‐infected adults have transient antigenemia, 25 percent have a primary antibody response without primary antigenemia, and 5 percent become chronic carriers, the overall chance of being detected by the HBsAg test was 42 percent, for an adjustment factor of 2.38. The total HBV incidence rate, therefore, was estimated to be 9.54 per 100,000 person‐years. CONCLUSION: The crude HBV incidence rate observed from HBsAg test results will underestimate the true rate. The adjusted HBV incidence rate should be used in applications such as estimations of residual HBV risk to the blood supply and projections of the benefits of screening for HBV DNA.
Transfusion – Wiley
Published: Jun 1, 1997
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