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J. Garthwaite, G. Garthwaite, R. Palmer, S. Moncada (1989)
NMDA receptor activation induces nitric oxide synthesis from arginine in rat brain slices.European journal of pharmacology, 172 4-5
O. Lowry, N. Rosebrough, A. Farr, R. Randall (1951)
Protein measurement with the Folin phenol reagent.The Journal of biological chemistry, 193 1
D. Bredt, P. Hwang, S. Snyder (1990)
Localization of nitric oxide synthase indicating a neural role for nitric oxideNature, 347
Garthwaite Garthwaite (1985)
Cellular uptake disguises action of l‐glutamate on N‐methyl‐D‐aspartate receptorsBr. J. Pharmacol., 85
K. Shibuki, D. Okada (1991)
Endogenous nitric oxide release required for long-term synaptic depression in the cerebellumNature, 349
G. Wilkin, R. Balázs, John Wilson, James Cohen, G. Dutton (1976)
Preparation of cell bodies from the developing cerebellum: Structural and metabolic integrity of the isolated ‘cells’Brain Research, 115
L. Wiklund, G. Toggenburger, M. Cuénod (1982)
Aspartate: possible neurotransmitter in cerebellar climbing fibers.Science, 216 4541
P. Wood, M. Emmett, T. Rao, J. Cler, S. Mick, S. Iyengar (1990)
Inhibition of Nitric Oxide Synthase Blocks N‐Methyl‐D‐Aspartate‐, Quisqualate‐, Kainate‐, Harmaline‐, and Pentylenetetrazole‐Dependent Increases in Cerebellar Cyclic GMP In VivoJournal of Neurochemistry, 55
D. Olson, C. Kon, B. Breckenridge (1976)
Calcium ion effects on guanylate cyclase of brain.Life sciences, 18 9
P. Dubbin, M. Zambetis, G. Dusting (1990)
INHIBITION OF ENDOTHELIAL NITRIC OXIDE BIOSYNTHESIS BY N‐NITRO‐l‐ARGININEClinical and Experimental Pharmacology and Physiology, 17
M. Sandoval, C. Cotman (1978)
Evaluation of glutamate as a neurotransmitter of cerebellar parallel fibersNeuroscience, 3
N. Maeda, M. Niinobe, K. Mikoshiba (1990)
A cerebellar Purkinje cell marker P400 protein is an inositol 1,4,5‐trisphosphate (InsP3) receptor protein. Purification and characterization of InsP3 receptor complex.The EMBO Journal, 9
S. Shenolikar, W. Thompson, S. Strada (1985)
Characterization of a Ca2+-calmodulin-stimulated cyclic GMP phosphodiesterase from bovine brain.Biochemistry, 24 3
W. Danysz, J. Wroblewski, G. Brooker, E. Costa (1989)
Modulation of glutamate receptors by phencyclidine and glycine in the rat cerebellum: cGMP increase in vivoBrain Research, 479
J. Garthwaite, S. Charles, R. Chess-Williams (1988)
Endothelium-derived relaxing factor release on activation of NMDA receptors suggests role as intercellular messenger in the brainNature, 336
D. Bredt, S. Snyder (1990)
Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme.Proceedings of the National Academy of Sciences of the United States of America, 87 2
(1990)
Larginine into an activator of soluble guanylyl cyclase
P. Myers, R. Minor, R. Guerra, J. Bates, D. Harrison (1990)
Vasorelaxant properties of the endothelium-derived relaxing factor more closely resemble S-nitrosocysteine than nitric oxideNature, 345
S. Katsuki, Arnold Wp, C. Mittal, F. Murad (1977)
Stimulation of guanylate cyclase by sodium nitroprusside, nitroglycerin and nitric oxide in various tissue preparations and comparison to the effects of sodium azide and hydroxylamine.Journal of cyclic nucleotide research, 3 1
Ferdinando Nicoletti, J. Wroblewski, A. Novelli, H. Alho, Alessandro Guidotti, Erminio Costa (1986)
The activation of inositol phospholipid metabolism as a signal- transducing system for excitatory amino acids in primary cultures of cerebellar granule cells, 6
D. Rees, R. Palmer, R. Schulz, H. Hodson, S. Moncada (1990)
Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivoBritish Journal of Pharmacology, 101
P. Worley, J. Baraban, S. Snyder (1989)
Inositol 1,4,5-trisphosphate receptor binding: autoradiographic localization in rat brain, 9
J. Wroblewski, Ferdinando Nicoletti, E. Fadda, Erminio Costa (1987)
Phencyclidine is a negative allosteric modulator of signal transduction at two subclasses of excitatory amino acid receptors.Proceedings of the National Academy of Sciences of the United States of America, 84 14
M. Marletta, P. Yoon, R. Iyengar, C. Leaf, J. Wishnok (1988)
Macrophage oxidation of L-arginine to nitrite and nitrate: nitric oxide is an intermediate.Biochemistry, 27 24
J. Garthwaite, E. Southam, M. Anderton (1989)
A Kainate Receptor Linked to Nitric Oxide Synthesis from ArginineJournal of Neurochemistry, 53
R. Palmer, D. Ashton, S. Moncada (1988)
Vascular endothelial cells synthesize nitric oxide from L-arginineNature, 333
Richard Knowles, M. Palacios, R. Palmer, S. Moncada (1989)
Formation of nitric oxide from L-arginine in the central nervous system: a transduction mechanism for stimulation of the soluble guanylate cyclase.Proceedings of the National Academy of Sciences of the United States of America, 86 13
A. Novelli, F. Nicoletti, J. Wroblewski, H. Alho, E. Costa, A. Guidotti (1987)
Excitatory amino acid receptors coupled with guanylate cyclase in primary cultures of cerebellar granule cells, 7
Sandoval Sandoval, Cotman Cotman (1978)
Evaluation of glutamate as a neurotransmitter in cerebellar climbing fibersNeuroscience, 3
C. Mao, A. Guidotti, E. Costa (1974)
The regulation of cyclic guanosine monophosphate in rat cerebellum: possible involvement of putative amino acid neurotransmitters.Brain research, 79 3
M. Radomski, R. Palmer, S. Moncada (1990)
An L-arginine/nitric oxide pathway present in human platelets regulates aggregation.Proceedings of the National Academy of Sciences of the United States of America, 87 13
Harld Schmidt, Jennifer Pollock, Masaki Nakane, L. Gorsky, Ulrich Förstermann, Ferid Murad (1991)
Purification of a soluble isoform of guanylyl cyclase-activating-factor synthase.Proceedings of the National Academy of Sciences of the United States of America, 88 2
Mayer Mayer, John John, Böhme Böhme (1990)
Purification of a Ca 2+ /calmodulin‐dependent nitric oxide synthase from porcine cerebellum: cofactor role of tetrahydrobiopterinFEBS Lett., 277
J. Wroblewski, F. Nicoletti, E. Costa (1985)
Different coupling of excitatory amino acid receptors with Ca2+ channels in primary cultures of cerebellar granule cellsNeuropharmacology, 24
J. Garthwaite (1982)
Excitatory amino acid receptors and guanosine 3',5'-cyclic monophosphate in incubated slices of immature and adult rat cerebellumNeuroscience, 7
C. Carter, F. Scatton (1987)
Ionic Mechanisms Implicated in the Stimulation of Cerebellar Cyclic GMP Levels by N‐Methyl‐D‐AspartateJournal of Neurochemistry, 49
J. Wroblewski, Wojciech Danysz (1989)
Modulation of glutamate receptors: molecular mechanisms and functional implications.Annual review of pharmacology and toxicology, 29
S. Hauschildt, A. Lückhoff, A. Mülsch, J. Kohler, W. Bessler, R. Busse (1990)
Induction and activity of NO synthase in bone-marrow-derived macrophages are independent of Ca2+.The Biochemical journal, 270 2
B. Mayer, Mathias John, E. Böhme (1990)
Purification of a Ca2+/calmodulin‐dependent nitric oxide synthase from porcine cerebellumFEBS Letters, 277
R. Palmer, A. Ferrige, S. Moncada (1987)
Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factorNature, 327
Bernd Mayer, K. Schmidt, P. Humbert, E. Böhme (1989)
Biosynthesis of endothelium-derived relaxing factor: a cytosolic enzyme in porcine aortic endothelial cells Ca2+-dependently converts L-arginine into an activator of soluble guanylyl cyclase.Biochemical and biophysical research communications, 164 2
J. Garthwaite (1985)
Cellular uptake disguises action of L‐glutamate on N‐methyl‐D‐aspartate receptors: With an appendix: Diffusion of transported amino acids into brain slicesBritish Journal of Pharmacology, 85
Markus Hecker, William Sessa, Hayley Harris, Erik Änggård, John Vane (1990)
The metabolism of L-arginine and its significance for the biosynthesis of endothelium-derived relaxing factor: cultured endothelial cells recycle L-citrulline to L-arginine.Proceedings of the National Academy of Sciences of the United States of America, 87
Bernard Vliet, M. Sebben, A. Dumuis, J. Gabrion, J. Bockaert, J. Pin (1989)
Endogenous Amino Acid Release from Cultured Cerebellar Neuronal Cells: Effect of Tetanus Toxin on Glutamate ReleaseJournal of Neurochemistry, 52
D. Bredt, S. Snyder (1989)
Nitric oxide mediates glutamate-linked enhancement of cGMP levels in the cerebellum.Proceedings of the National Academy of Sciences of the United States of America, 86 22
B. Dickie, M. Lewis, J. Davies (1990)
Potassium‐stimulated release of nitric oxide from cerebellar slicesBritish Journal of Pharmacology, 101
S. Ratner, H. Morell, E. Carvalho (1960)
Enzymes of arginine metabolism in brain.Archives of biochemistry and biophysics, 91
R. Furchgott, J. Zawadzki (1980)
The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholineNature, 288
J. Ferrendelli, M. Chang, D. Kinscherf (1974)
ELEVATION OF CYCLIC GMP LEVELS IN CENTRAL NERVOUS SYSTEM BY EXCITATORY AND INHIBITORY AMINO ACIDS 1Journal of Neurochemistry, 22
Abstract: The glutamate receptor agonist N‐methyl‐D‐aspartate (NMDA) stimulated a rapid, extracellular Ca2+‐dependent conversion of (3H)arginine to (3H)citrulline in primary cultures of cerebellar granule cells, indicating receptor‐mediated activation of nitric oxide (NO) synthase. The NMDA‐induced formation of (3H)citrulline reached a plateau within 10 min. Subsequent addition of unlabeled l‐arginine resulted in the disappearance of 3H from the citrulline pool, indicating a persistent activation of NO synthase after NMDA receptor stimulation. Glutamate, NMDA, and kainate, but not quisqualate, stimulated both the conversion of (3H)arginine to (3H)citrulline and cyclic GMP accumulation in a dose‐dependent manner. Glutamate and NMDA showed similar potencies for the stimulation of (3H)citrulline formation and cyclic GMP synthesis, respectively, whereas kainate was more potent at inducing cyclic GMP accumulation than at stimulating (3H)citrulline formation. Both the (3H)arginine to (3H)citrulline conversion and cyclic GMP synthesis stimulated by NMDA were inhibited by the NMDA receptor antagonist MK‐801 and by the inhibitors of NO synthase, NG‐monomethyl‐L‐arginine (MeArg) and NG‐nitro‐L‐arginine (NOArg). However, MeArg, in contrast to NOArg, also potently inhibited (3H)arginine uptake. Kainate (300 μM) stimulated 45Ca2+ influx to the same extent as 100 μM NMDA, but stimulated (3H)citrulline formation to a much lesser extent, which suggests that NO synthase is localized in subcellular compartments where the Ca2+ concentration is regulated mainly by the NMDA receptor.
Journal of Neurochemistry – Wiley
Published: Jan 1, 1992
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