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A Biologic Approach to Cutaneous Vascular Anomalies

A Biologic Approach to Cutaneous Vascular Anomalies Children's Hospital, Boston, Massachusetts One decade ago a biologic classification of vascular anomalies was introduced, based on correlative studies of cellular features, physical examination, and natural history (1). The medical literature, however, continues to employ such nineteenthcentury misnomers as port-wine hemangioma, cavernous hemangioma, and cystic hygroma. Indeed, it is Nature's design that the majority of her cutaneous vascular birthmarks are either hemangiomas, characterized by increased endothelial turnover, or malformations, characterized by normal endothelial cell cycle (2). Hemangiomas grow rapidly in the postnatal period, followed invariably by slow involution. The sex ratio for these most common tumors of infancy is 3:1 female;male. Vascular malformations are, by definition, present at birth; however, they may not manifest until childhood, adolescence, or sometimes adulthood. Vascular malformations grow commensuratety or they may expand secondary to trauma, sepsis, or hormonal modulation. They have no predilection for either sex. The cellular characteristics of hemangioma include endothelial hyperplasia and increased numbers of mast cells. Once a hemangioma is completely involuted, the mast cell count returns to normal (3). Hemangiomas exhibit multitaminated basement membranes and capillary tubular formation in vitro. In contrast, vascular malformations exhibit flat endothelium with imperceptible cell turnover, normal mast celi levels, and thin http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Pediatric Dermatology Wiley

A Biologic Approach to Cutaneous Vascular Anomalies

Mulliken, John B.
Pediatric Dermatology , Volume 9 (4) – Dec 1, 1992
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References (9)

Publisher
Wiley
Copyright
Copyright © 1992 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0736-8046
eISSN
1525-1470
DOI
10.1111/j.1525-1470.1992.tb00629.x
Publisher site
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Abstract

Children's Hospital, Boston, Massachusetts One decade ago a biologic classification of vascular anomalies was introduced, based on correlative studies of cellular features, physical examination, and natural history (1). The medical literature, however, continues to employ such nineteenthcentury misnomers as port-wine hemangioma, cavernous hemangioma, and cystic hygroma. Indeed, it is Nature's design that the majority of her cutaneous vascular birthmarks are either hemangiomas, characterized by increased endothelial turnover, or malformations, characterized by normal endothelial cell cycle (2). Hemangiomas grow rapidly in the postnatal period, followed invariably by slow involution. The sex ratio for these most common tumors of infancy is 3:1 female;male. Vascular malformations are, by definition, present at birth; however, they may not manifest until childhood, adolescence, or sometimes adulthood. Vascular malformations grow commensuratety or they may expand secondary to trauma, sepsis, or hormonal modulation. They have no predilection for either sex. The cellular characteristics of hemangioma include endothelial hyperplasia and increased numbers of mast cells. Once a hemangioma is completely involuted, the mast cell count returns to normal (3). Hemangiomas exhibit multitaminated basement membranes and capillary tubular formation in vitro. In contrast, vascular malformations exhibit flat endothelium with imperceptible cell turnover, normal mast celi levels, and thin

Journal

Pediatric Dermatology – Wiley

Published: Dec 1, 1992

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