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BEVERLEY GREENWOOD JOSEPH A. DIMICCO Department of Pharmacology Toxicology, Indiana University School of Medicine, Indianapolis, Indiana 46202 Greenwood, Beverley, Joseph A. DiMicco. Activation of the stimulates in rats. Am. J. Physiol. 268 (Gastrointest. Liver PhysioZ. 31): G514-G521, 1995.-Blockade of y-aminobutyric acid* (GABA*) receptors in the of the hypothalamus (DMH) in rats induced cardiovascular behavioral changes resembling those associated with emotional stress. The purpose of this study was to test the hypothesis that microinjection of the GABA antagonist bicuculline methiodide (BMI) into the DMH of anesthetized rats would produce increases in measured manometrically with saline-filled cannulas. Arterial pressure heart rate were also recorded. Microinjection of BMI (15-30 pmol/l5 nl) into the region of the DMH elicited reproducible dose-related increases in jejunal , ic , heart rate, arterial pressure. Similar microinjection at sites anterior to the DMH into or nearer to the paraventricular elicited significantly attenuated cardiovascular effects accompanied by either no change in function or changes that were significantly reduced. Either vagotomy or treatment with atropine methyl bromide (1 mg/kg iv) blocked the increase in jejunal reduced but did not abolish the ic stimulation. Increases in heart rate arterial pressure were essentially unaffected by either intervention. The observations suggest
AJP - Gastrointestinal and Liver Physiology – The American Physiological Society
Published: Mar 1, 1995
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