Access the full text.
Sign up today, get DeepDyve free for 14 days.
References for this paper are not available at this time. We will be adding them shortly, thank you for your patience.
Minkes, Robert K., Timothy J. McMahon, Todd R. Higuera, William A. Murphy, David H. Coy, Philip J. Kadowitz. Analysis of systemic pulmonary vascular s VIP: role of catecholamines. Am. J. Physiol. 263 (Heart Circ. Physiol. 32): H1659-H1669, 1992.-Systemic pulmonary vascular s to pituitary adenylate cyclase-activating polypeptide (), a novel peptide with 68% sequence homology to vasoactive intestinal peptide (VIP), were investigated in the anesthetized cat. Intravenous injections of in doses of 0.1-3.0 nmol/kg produced decreases in arterial pressure (AP) at low doses biphasic changes (decreases followed by increases) at higher doses, which were accompanied by increases in central venous pressure (CVP) cardiac output (CO), decreases biphasic changes in systemic vascular resistance (SVR). In contrast, VIP in doses of 0.1-3.0 nmol/kg produced only dose-dependent decreases in AP SVR produced little change in CVP CO. produced increased pulmonary arterial pressure (PAP), left atria1 pressure (LAP), increases in pulmonary vascular resistance (PVR). increased heart rate (HR) right ventricular contractile force (RVCF), while VIP had no effect. Increases in AP SVR in were changed to decreases following the administration of phentolamine or after ectomy. Under constant flow conditions, VIP produced dose-dependent decreases in lobar arterial pressure when tone was elevated, with being
AJP - Heart and Circulatory Physiology – The American Physiological Society
Published: Dec 1, 1992
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.