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The affinity of the non‐peptide antagonist CP‐96,345 for tachykinin NK1 receptors has been estimated in a range of species by use of both radioligand binding and functional assays. CP‐96,345 was 30–120 fold less active at NK1 receptors in rat and mouse than in the other species examined, including man. These results demonstrate the existence of species variations in NK1 receptors.
British Journal of Pharmacology – Wiley
Published: Oct 1, 1991
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