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Investigation into species variants in tachykinin NK 1 receptors by use of the non‐peptide antagonist, CP‐96,345

Investigation into species variants in tachykinin NK 1 receptors by use of the non‐peptide... The affinity of the non‐peptide antagonist CP‐96,345 for tachykinin NK1 receptors has been estimated in a range of species by use of both radioligand binding and functional assays. CP‐96,345 was 30–120 fold less active at NK1 receptors in rat and mouse than in the other species examined, including man. These results demonstrate the existence of species variations in NK1 receptors. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png British Journal of Pharmacology Wiley

Investigation into species variants in tachykinin NK 1 receptors by use of the non‐peptide antagonist, CP‐96,345

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References (8)

Publisher
Wiley
Copyright
1991 British Pharmacological Society
ISSN
0007-1188
eISSN
1476-5381
DOI
10.1111/j.1476-5381.1991.tb12423.x
Publisher site
See Article on Publisher Site

Abstract

The affinity of the non‐peptide antagonist CP‐96,345 for tachykinin NK1 receptors has been estimated in a range of species by use of both radioligand binding and functional assays. CP‐96,345 was 30–120 fold less active at NK1 receptors in rat and mouse than in the other species examined, including man. These results demonstrate the existence of species variations in NK1 receptors.

Journal

British Journal of PharmacologyWiley

Published: Oct 1, 1991

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