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D. Orth, W. Nicholson (1982)
Bioactive and immunoreactive adrenocorticotropin in normal equine pituitary and in pituitary tumors of horses with Cushing's disease.Endocrinology, 111 2
D. Peters, J. Erfle, G. Slobojan (1995)
Low-dose pergolide mesylate treatment for equine hypophyseal adenomas (Cushing's syndrome), 41
D. McFarlane, D. Sellon, D. Gaffney, Hedgpeth, M. Papich, S. Gibbs (1998)
Hematologic and serum biochemical variables and plasma corticotropin concentration in healthy aged horses.American journal of veterinary research, 59 10
J. Meakin, W. Tingey, D. Nelson (1960)
THE CATABOLISM OF ADRENOCORTICOTROPIC HORMONE: THE STABILITY OF ADRENOCORTICOTROPIC HORMONE IN BLOOD, PLASMA, SERUM, AND SALINE1Endocrinology, 66
J. Gutkowska, J. Julesz, J. St-Louis, J. Genest (1982)
Radioimmunoassay of corticotropin from plasma.Clinical chemistry, 28 11
S. Luna, P. Taylor (1995)
Pituitary-adrenal activity and opioid release in ponies during thiopentone/halothane anaesthesia.Research in veterinary science, 58 1
C. Redekopp, C. Irvine, R. Donald, J. Livesey, W. Sadler, M. Nicholls, S. Alexander, M. Evans (1986)
Spontaneous and stimulated adrenocorticotropin and vasopressin pulsatile secretion in the pituitary venous effluent of the horse.Endocrinology, 118 4
Couetil Couetil (1996)
Clinical response and plasma adrenocorticotropin concentration in horses with equine Cushing's disease treated with cyproheptadineProc. Am. Ass. equine Practnrs., 42
Levy Levy, Dybdal Dybdal (1999)
Diagnosis and treatment of equine Cushing's diseaseComp. cont. Educ. pract. Vet., 21
R. McCarthy, L. Jeffcott, J. Funder, M. Fullerton, I. Clarke (1991)
Plasma beta-endorphin and adrenocorticotrophin in young horses in training.Australian veterinary journal, 68 11
L. Couëtil, M. Paradis, Joyce Knoll (1996)
Plasma adrenocorticotropin concentration in healthy horses and in horses with clinical signs of hyperadrenocorticism.Journal of veterinary internal medicine, 10 1
J. Kolk, T. Wensing, H. Kalsbeek, H. Breukink (1995)
Laboratory diagnosis of equine pituitary pars intermedia adenoma.Domestic animal endocrinology, 12 1
H. Eiler, J. Oliver, F. Andrews, K. Fecteau, E. Green, M. Mccracken (1997)
Results of a combined dexamethasone suppression/thyrotropin-releasing hormone stimulation test in healthy horses and horses suspected to have a pars intermedia pituitary adenoma.Journal of the American Veterinary Medical Association, 211 1
Ng Ng, Chung Chung, Li Li (1981)
Isolation and properties of β‐endorphin‐(1–27), Na‐acetyl‐β‐endorphin, corticotropin, gamma‐lipotropin and neurophysin from equine pituitary glandsInt. J. Peptide Protein Res., 18
N. Dybdal, Kenneth Hargreaves, John Madigan, D. Gribble, P. Kennedy, G. Stabenfeldt (1994)
Diagnostic testing for pituitary pars intermedia dysfunction in horses.Journal of the American Veterinary Medical Association, 204 4
D. Orth, M. Holscher, M. Wilson, W. Nicholson, R. Plue, C. Mount (1982)
Equine Cushing's disease: plasma immunoreactive proopiolipomelanocortin peptide and cortisol levels basally and in response to diagnostic tests.Endocrinology, 110 4
R. Donald (1967)
A rapid method for extracting corticotrophin from plasma.The Journal of endocrinology, 39 3
Beech (1984)
Treatment of hypophyseal adenomasComp. cont. Educ. pract. Vet., 16
McGowan McGowan, Neiger Neiger (2001)
Efficacy of trilostane in the management of equine Cushing's diseaseProc. Am. Coll. vet. int. Med., 19
A. Lambert, J. Frost, W. Ratcliffe, W. Robertson (1985)
ON THE STABILITY IN VITRO OF BIOACTIVE HUMAN ADRENOCORTICOTROPHIN IN BLOOD AND PLASMAClinical Endocrinology, 23
Hegstad Rl, Shirley Johnston, Pasternak Dm (1990)
Effects of sample handling on adrenocorticotropin concentration measured in canine plasma, using a commercially available radioimmunoassay kit.American journal of veterinary research, 51 12
D. Beck (1992)
Effective long-term treatment of a suspected pituitary adenoma with bromocriptine mesylate in a ponyEquine Veterinary Education, 4
T. Okada, T. Shimomuro, M. Oikawa, Y. Nambo, Y. Kiso, Y. Morikawa, R. Liptrap, S. Yamashiro, P. Little, F. Sasaki (1997)
Immunocytochemical localization of adrenocorticotropic hormone-immunoreactive cells of the pars intermedia in thoroughbreds.American journal of veterinary research, 58 8
P. Toutain, M. Oukessou, A. Autefage, Michel Alvinerie (1988)
Diurnal and episodic variations of plasma hydrocortisone concentrations in horses.Domestic animal endocrinology, 5 1
J. Beech, M. Garcia (1985)
Hormonal response to thyrotropin-releasing hormone in healthy horses and in horses with pituitary adenoma.American journal of veterinary research, 46 9
J. Moore, J. Steiss, W. Nicholson, D. Orth (1979)
A case of pituitary adrenocorticotropin-dependent Cushing's syndrome in the horse.Endocrinology, 104 3
N. Hodson, J. Wright, J. Hunt (1986)
The sympatho-adrenal system and plasma levels of adrenocorticotropic hormone, cortisol and catecholamines in equine grass sicknessVeterinary Record, 119
Watson Watson, Dybdal Dybdal, Herrgesell Herrgesell, Koblik Koblik, Madigan Madigan (1998)
Equine Cushing's disease and the long‐term treatment with oral pergolide mesylateProc. Am. Coll. vet. Int. Med., 16
J. Kolk, J. Ijzer, P. Overgaauw, J. Linde‐Sipman (2001)
Pituitary-independent Cushing's syndrome in a horse.Equine veterinary journal, 33 1
J. Stouffer, H. Lipscomb (1963)
Reversibel binding of ACTH to a glass surface.Endocrinology, 72
S. Alexander, C. Irvine, M. Ellis, R. Donald (1991)
The effect of acute exercise on the secretion of corticotropin-releasing factor, arginine vasopressin, and adrenocorticotropin as measured in pituitary venous blood from the horse.Endocrinology, 128 1
M. Heinrichs, W. Baumgärtner, C. Capen (1990)
Immunocytochemical Demonstration of Proopiomelanocortin-derived Peptides in Pituitary Adenomas of the Pars Intermedia in HorsesVeterinary Pathology, 27
T. Cudd, M. Leblanc, M. Silver, W. Norman, J. Madison, M. Keller‐Wood, C. Wood (1995)
Ontogeny and ultradian rhythms of adrenocorticotropin and cortisol in the late-gestation fetal horse.The Journal of endocrinology, 144 2
Nagata Nagata, Takeda Takeda, Kurosawa Kurosawa, Mima Mima, Hiraga Hiraga, Kai Kai, Taya Taya (1999)
Plasma adrenocortictropin, cortisol and catecholamines response to various exercisesEquine vet. J., 30
P. Taylor (1989)
Equine stress responses to anaesthesia.British journal of anaesthesia, 63 6
M. Wilson, W. Nicholson, M. Holscher, B. Sherrell, C. Mount, D. Orth (1982)
Proopiolipomelanocortin peptides in normal pituitary, pituitary tumor, and plasma of normal and Cushing's horses.Endocrinology, 110 3
Sandy Love (1993)
Equine Cushing's disease.The British veterinary journal, 149 2
W. Millington, N. Dybdal, R. Dawson, C. Manzini, G. Mueller (1988)
Equine Cushing's disease: differential regulation of beta-endorphin processing in tumors of the intermediate pituitary.Endocrinology, 123 3
Summary Plasma ACTH levels have been variable in horses with a positive clinical response for therapy for equine Cushing's Disease (ECD). Therefore, our purpose was to determine the value of monitoring plasma adrenocorticotropin (ACTH) levels during treatment of equine Cushing's disease (ECD) with either cyproheptadine (n = 32) or pergolide (n = 10). First, we validated the chemiluminescent ACTH assay (specificity, precision, accuracy, intra‐assay and interassay variations) and tested methods of handling the whole blood from the time of collection to when the ACTH was assayed. The sensitivity and specificity of high plasma ACTH levels for detecting ECD was determined in a retrospective study on hospitalised horses (n = 68). Surveys were sent to veterinarians who submitted equine ACTH levels that were high initially and had at least 2 ACTH samples to determine the value of monitoring ACTH levels during therapy of ECD. The ACTH chemiluminescent assay was valid. The ACTH was stable when whole blood was collected and held in plastic tubes for 8h before separating the plasma. The sensitivity and specificity of plasma ACTH levels for detecting ECD were 84% (n = 19, 95% CI 60, 97) and 78% (n = 49, 95% CI 63, 88), respectively. Treated horses generally showed a decrease in plasma ACTH. Plasma ACTH levels may be helpful when monitoring therapy of ECD, although improvement in clinical signs should be considered most important. There were no differences between cyproheptadine and pergolide in terms of improvements in any of the clinical signs.
Equine Veterinary Journal – Wiley
Published: Nov 1, 2002
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