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Genetic evolution of enterovirus 71: epidemiological and pathological implications

Genetic evolution of enterovirus 71: epidemiological and pathological implications Since its discovery in the 1970s, enterovirus 71 (EV71) has become one of the most pathogenic enterovirus serotypes causing recurrent outbreaks in different parts of the world. Three waves of outbreaks globally have been recorded over the last three decades and more recently active circulation of EV71 is evident amongst countries in South East Asia and beyond. There is evidence of a continuous evolution in its genetic make up which is likely to impact on its epidemiology and pathological potential. This review examines the molecular genetics and evolution of EV71 in relation to its epidemiological and pathological properties. A thorough understanding of the relationship between the genetic changes and the resulting host–virus interaction is essential for successful control. Copyright © 2007 John Wiley & Sons, Ltd. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reviews in Medical Virology Wiley

Genetic evolution of enterovirus 71: epidemiological and pathological implications

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References (80)

Publisher
Wiley
Copyright
Copyright © 2007 John Wiley & Sons, Ltd.
ISSN
1052-9276
eISSN
1099-1654
DOI
10.1002/rmv.538
pmid
17487831
Publisher site
See Article on Publisher Site

Abstract

Since its discovery in the 1970s, enterovirus 71 (EV71) has become one of the most pathogenic enterovirus serotypes causing recurrent outbreaks in different parts of the world. Three waves of outbreaks globally have been recorded over the last three decades and more recently active circulation of EV71 is evident amongst countries in South East Asia and beyond. There is evidence of a continuous evolution in its genetic make up which is likely to impact on its epidemiology and pathological potential. This review examines the molecular genetics and evolution of EV71 in relation to its epidemiological and pathological properties. A thorough understanding of the relationship between the genetic changes and the resulting host–virus interaction is essential for successful control. Copyright © 2007 John Wiley & Sons, Ltd.

Journal

Reviews in Medical VirologyWiley

Published: Nov 1, 2007

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