Access the full text.
Sign up today, get DeepDyve free for 14 days.
F. Moore, J. Weekes, D. Hardie (1991)
Evidence that AMP triggers phosphorylation as well as direct allosteric activation of rat liver AMP-activated protein kinase. A sensitive mechanism to protect the cell against ATP depletion.European journal of biochemistry, 199 3
M. Shiao, R. Drong, J. Porter (1981)
The purification and properties of a protein kinase and the partial purification of a phosphoprotein phosphatase that inactivate and activate acetyl-CoA carboxylase.Biochemical and biophysical research communications, 98 1
D. Carling, D. Hardie (1989)
The substrate and sequence specificity of the AMP-activated protein kinase. Phosphorylation of glycogen synthase and phosphorylase kinase.Biochimica et biophysica acta, 1012 1
L. Kluijtmans, G. Boers, E. Stevens, Willy Renier, Jan Kraus, Frans Trijbels, L. Heuvel, Henk Blom (1996)
Defective cystathionine beta-synthase regulation by S-adenosylmethionine in a partially pyridoxine responsive homocystinuria patient.The Journal of clinical investigation, 98 2
J. Weekes, S. Hawley, J. Corton, D. Shugar, D. Hardie (1994)
Activation of rat liver AMP-activated protein kinase by kinase kinase in a purified, reconstituted system. Effects of AMP and AMP analogues.European journal of biochemistry, 219 3
S. Davies, D. Carling, M. Munday, D. Hardie (1992)
Diurnal rhythm of phosphorylation of rat liver acetyl-CoA carboxylase by the AMP-activated protein kinase, demonstrated using freeze-clamping. Effects of high fat diets.European journal of biochemistry, 203 3
G. Velasco, Math Geelen, Manuel Guzmán (1997)
Control of hepatic fatty acid oxidation by 5'-AMP-activated protein kinase involves a malonyl-CoA-dependent and a malonyl-CoA-independent mechanism.Archives of biochemistry and biophysics, 337 2
Jyan-Chyun Jang, Jenq-Yunn Sheen (1994)
Sugar sensing in higher plants.The Plant cell, 6
W. Wilson, S. Hawley, D. Hardie (1996)
Glucose repression/derepression in budding yeast: SNF1 protein kinase is activated by phosphorylation under derepressing conditions, and this correlates with a high AMP:ATP ratioCurrent Biology, 6
G. Moorhead, P. Douglas, N. Morrice, M. Scarabel, A. Aitken, C. MacKintosh (1996)
Phosphorylated nitrate reductase from spinach leaves is inhibited by 14-3-3 proteins and activated by fusicoccinCurrent Biology, 6
D. Stapleton, Guang Gao, B. Michell, Jane Widmer, K. Mitchelhill, T. Teh, C. House, Lee Witters, B. Kemp (1994)
Mammalian 5'-AMP-activated protein kinase non-catalytic subunits are homologs of proteins that interact with yeast Snf1 protein kinase.The Journal of biological chemistry, 269 47
J. Celenza, M. Carlson (1989)
Mutational analysis of the Saccharomyces cerevisiae SNF1 protein kinase and evidence for functional interaction with the SNF4 proteinMolecular and Cellular Biology, 9
Ritossa Fm (1964)
EXPERIMENTAL ACTIVATION OF SPECIFIC LOCI IN POLYTENE CHROMOSOMES OF DROSOPHILA.Experimental Cell Research, 35
Z. Beg, D. Reznikov, J. Avigan (1986)
Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in human fibroblasts by reversible phosphorylation: modulation of enzymatic activity by low density lipoprotein, sterols, and mevalonolactone.Archives of biochemistry and biophysics, 244 1
M. Sintchak, M. Fleming, O. Futer, S. Raybuck, S. Chambers, P. Caron, M. Murcko, K. Wilson (1996)
Structure and Mechanism of Inosine Monophosphate Dehydrogenase in Complex with the Immunosuppressant Mycophenolic AcidCell, 85
D. Morrison, R. Cutler (1997)
The complexity of Raf-1 regulation.Current opinion in cell biology, 9 2
Guang Gao, Jane Widmer, D. Stapleton, T. Teh, Timothy Cox, B. Kemp, L. Witters (1995)
Catalytic subunits of the porcine and rat 5'-AMP-activated protein kinase are members of the SNF1 protein kinase family.Biochimica et biophysica acta, 1266 1
D. Alessi, M. Andjelkovic, Barry Caudwell, P. Cron, N. Morrice, P. Cohen, B. Hemmings (1996)
Mechanism of activation of protein kinase B by insulin and IGF‐1.The EMBO Journal, 15
J. Weekes, K. Ball, F. Caudwell, D. Hardie (1993)
Specificity determinants for the AMP‐activated protein kinase and its plant homologue analysed using synthetic peptidesFEBS Letters, 334
Thomas Hardy, Dongqing Huang, P. Roach (1994)
Interactions between cAMP-dependent and SNF1 protein kinases in the control of glycogen accumulation in Saccharomyces cerevisiae.The Journal of biological chemistry, 269 45
A. Garton, D. Campbell, P. Cohen, S. Yeaman (1988)
Primary structure of the site on bovine hormone‐sensitive lipase phosphorylated by cyclic AMP‐dependent protein kinaseFEBS Letters, 229
B. Lent, K. Kim (1982)
Purification and properties of a kinase which phosphorylates and inactivates acetyl-CoA carboxylase.The Journal of biological chemistry, 257 4
J. Dyck, G. Gao, J. Widmer, D. Stapleton, C. Fernandez, B. Kemp, L. Witters (1996)
Regulation of 5′-AMP-activated Protein Kinase Activity by the Noncatalytic β and γ Subunits*The Journal of Biological Chemistry, 271
A. Sprenkle, S. Davies, D. Carling, D. Hardie, T. Sturgill (1997)
Identification of Raf‐1 Ser621 kinase activity from NIH 3T3 cells as AMP‐activated protein kinaseFEBS Letters, 403
R. McMichael, Robert Klein, M. Salvucci, S. Huber (1993)
Identification of the major regulatory phosphorylation site in sucrose-phosphate synthase.Archives of biochemistry and biophysics, 307 2
J. Celenza, M. Carlson (1986)
A yeast gene that is essential for release from glucose repression encodes a protein kinase.Science, 233 4769
J. Corton, J. Gillespie, D. Hardie (1994)
Role of the AMP-activated protein kinase in the cellular stress responseCurrent Biology, 4
A. Bateman (1997)
The structure of a domain common to archaebacteria and the homocystinuria disease protein.Trends in biochemical sciences, 22 1
J. Tu, M. Carlson (1994)
The GLC7 type 1 protein phosphatase is required for glucose repression in Saccharomyces cerevisiaeMolecular and Cellular Biology, 14
Susan Dale, M. Arró, Beatriz Becerra, Nick Morrice, Albert Boronat, D. Hardie, A. Ferrer (1995)
Bacterial expression of the catalytic domain of 3-hydroxy-3-methylglutaryl-CoA reductase (isoform HMGR1) from Arabidopsis thaliana, and its inactivation by phosphorylation at Ser577 by Brassica oleracea 3-hydroxy-3-methylglutaryl-CoA reductase kinase.European journal of biochemistry, 233 2
F. Estruch, M. Treitel, X. Yang, M. Carlson (1992)
N-terminal mutations modulate yeast SNF1 protein kinase function.Genetics, 132 3
Toshiya Muranaka, H. Banno, Yasunori Machida (1994)
Characterization of tobacco protein kinase NPK5, a homolog of Saccharomyces cerevisiae SNF1 that constitutively activates expression of the glucose-repressible SUC2 gene for a secreted invertase of S. cerevisiaeMolecular and Cellular Biology, 14
A. Garton, D. Campbell, D. Carling, D. Hardie, R. Colbran, S. Yeaman (1989)
Phosphorylation of bovine hormone-sensitive lipase by the AMP-activated protein kinase. A possible antilipolytic mechanism.European journal of biochemistry, 179 1
N. Kudo, J. Gillespie, L. Kung, L. Witters, R. Schulz, A. Clanachan, G. Lopaschuk (1996)
Characterization of 5'AMP-activated protein kinase activity in the heart and its role in inhibiting acetyl-CoA carboxylase during reperfusion following ischemia.Biochimica et biophysica acta, 1301 1-2
Pascale Lesage, Xiaolu Yang, M. Carlson (1996)
Yeast SNF1 protein kinase interacts with SIP4, a C6 zinc cluster transcriptional activator: a new role for SNF1 in the glucose responseMolecular and Cellular Biology, 16
S. Hawley, Michele Selbert¶i, E. Goldstein, A. Edelman, D. Carling, G. Hardie (1995)
5′-AMP Activates the AMP-activated Protein Kinase Cascade, and Ca2+/Calmodulin Activates the Calmodulin-dependent Protein Kinase I Cascade, via Three Independent Mechanisms (*)The Journal of Biological Chemistry, 270
Naomi Kudo, A. Barr, R. Barr, Snehal Desai, G. Lopaschuk (1995)
High Rates of Fatty Acid Oxidation during Reperfusion of Ischemic Hearts Are Associated with a Decrease in Malonyl-CoA Levels Due to an Increase in 5′-AMP-activated Protein Kinase Inhibition of Acetyl-CoA Carboxylase (*)The Journal of Biological Chemistry, 270
K. Ball, J. Barker, Nigel Halford, D. Hardie (1995)
Immunological evidence that HMG‐CoA reductase kinase‐A is the cauliflower homologue of the RKIN1 subfamily of plant protein kinasesFEBS Letters, 377
L. Vallier, M. Carlson (1994)
Synergistic release from glucose repression by mig1 and ssn mutations in Saccharomyces cerevisiae.Genetics, 137 1
A. Ferrer, C. Caelles, N. Massot, F. Hegardt (1985)
Activation of rat liver cytosolic 3-hydroxy-3-methylglutaryl coenzyme A reductase kinase by adenosine 5'-monophosphate.Biochemical and biophysical research communications, 132 2
Lee Witters, Ann-Charlotte Nordlund, Lisa Marshall (1991)
Regulation of intracellular acetyl-CoA carboxylase by ATP depletors mimics the action of the 5'-AMP-activated protein kinase.Biochemical and biophysical research communications, 181 3
I. Graham, K. Denby, C. Leaver (1994)
Carbon Catabolite Repression Regulates Glyoxylate Cycle Gene Expression in Cucumber.The Plant cell, 6
S. Davies, S. Hawley, A. Woods, D. Carling, Timothy Haystead, D. Hardie (1994)
Purification of the AMP-activated protein kinase on ATP-gamma-sepharose and analysis of its subunit structure.European journal of biochemistry, 223 2
D. Carling, K. Aguan, A. Woods, A. Verhoeven, R. Beri, C. Brennan, C. Sidebottom, M. Davison, James Scott (1994)
Mammalian AMP-activated protein kinase is homologous to yeast and plant protein kinases involved in the regulation of carbon metabolism.The Journal of biological chemistry, 269 15
R. Arebalo, J. Hardgrave, B. Noland, T. Scallen (1980)
In vivo regulation of rat liver 3-hydroxy-3-methylglutaryl-coenzyme A reductase: enzyme phosphorylation as an early regulatory response after intragastric administration of mevalonolactone.Proceedings of the National Academy of Sciences of the United States of America, 77 11
T. Ingebritsen, H. Lee, R. Parker, D. Gibson (1978)
Reversible modulation of the activities of both liver microsomal hydroxymethylglutaryl coenzyme A reductase and its inactivating enzyme. Evidence for regulation by phosphorylation-dephosphorylation.Biochemical and biophysical research communications, 81 4
L. Witters, B. Kemp (1992)
Insulin activation of acetyl-CoA carboxylase accompanied by inhibition of the 5'-AMP-activated protein kinase.The Journal of biological chemistry, 267 5
D. Vavvas, A. Apazidis, A. Saha, J. Gamble, A. Patel, B. Kemp, L. Witters, N. Ruderman (1997)
Contraction-induced Changes in Acetyl-CoA Carboxylase and 5′-AMP-activated Kinase in Skeletal Muscle*The Journal of Biological Chemistry, 272
G. Gao, C. Fernandez, D. Stapleton, A. Auster, J. Widmer, J. Dyck, B. Kemp, L. Witters (1996)
Non-catalytic - and -Subunit Isoforms of the 5′-AMP-activated Protein Kinase (*)The Journal of Biological Chemistry, 271
J. Ha, Samira Daniel, S. Broyles, Ki‐han Kim (1994)
Critical phosphorylation sites for acetyl-CoA carboxylase activity.The Journal of biological chemistry, 269 35
S. Davies, A. Sim, D. Hardie (1990)
Location and function of three sites phosphorylated on rat acetyl-CoA carboxylase by the AMP-activated protein kinase.European journal of biochemistry, 187 1
J. Ha, J. Lee, K. Kim, L. Witters, K. Kim (1996)
Cloning of human acetyl-CoA carboxylase-beta and its unique features.Proceedings of the National Academy of Sciences of the United States of America, 93 21
J. Celenza, F. Eng, M. Carlson (1989)
Molecular analysis of the SNF4 gene of Saccharomyces cerevisiae: evidence for physical association of the SNF4 protein with the SNF1 protein kinaseMolecular and Cellular Biology, 9
K. Matsumoto, A. Toh-e, Y. Oshima (1981)
Isolation and characterization of dominant mutations resistant to carbon catabolite repression of galactokinase synthesis in Saccharomyces cerevisiaeMolecular and Cellular Biology, 1
Curtis Carlson, Ki-Han Kim (1973)
Regulation of hepatic acetyl coenzyme A carboxylase by phosphorylation and dephosphorylation.The Journal of biological chemistry, 248 1
M. Simon, M. Binder, G. Adam, A. Hartig, H. Ruis (1992)
Control of peroxisome proliferation in Saccharomyces cerevisiae by ADR1, SNF1 (CAT1, CCR1) and SNF4 (CAT3)Yeast, 8
J. Monod, J. Wyman, J. Changeux (1965)
ON THE NATURE OF ALLOSTERIC TRANSITIONS: A PLAUSIBLE MODEL.Journal of molecular biology, 12
Xiaolu Yang, Rong Jiang, M. Carlson (1994)
A family of proteins containing a conserved domain that mediates interaction with the yeast SNF1 protein kinase complex.The EMBO Journal, 13
E. Hubbard, X. Yang, M. Carlson (1992)
Relationship of the cAMP-dependent protein kinase pathway to the SNF1 protein kinase and invertase expression in Saccharomyces cerevisiae.Genetics, 130 1
D. Tzamarias, K. Struhl (1994)
Functional dissection of the yeast Cyc8–Tupl transcriptional co-repressor complexNature, 369
K. Mitchelhill, D. Stapleton, G. Gao, C. House, B. Michell, Frosa Katsis, L. Witters, B. Kemp (1994)
Mammalian AMP-activated protein kinase shares structural and functional homology with the catalytic domain of yeast Snf1 protein kinase.The Journal of biological chemistry, 269 4
S. Hawley, M. Davison, Angela Woodsi, S. Davies, R. Beri, David Carlingi, G. Hardie (1996)
Characterization of the AMP-activated Protein Kinase Kinase from Rat Liver and Identification of Threonine 172 as the Major Site at Which It Phosphorylates AMP-activated Protein Kinase*The Journal of Biological Chemistry, 271
Nathalie Henin, M. Vincent, H. Gruber, G. Berghe (1995)
Inhibition of fatty acid and cholesterol synthesis by stimulation of AMP‐activated protein kinaseThe FASEB Journal, 9
A. Alderson, P. Sabelli, J. Dickinson, D. Cole, M. Richardson, M. Kreis, P. Shewry, Nigel Halford (1991)
Complementation of snf1, a mutation affecting global regulation of carbon metabolism in yeast, by a plant protein kinase cDNA.Proceedings of the National Academy of Sciences of the United States of America, 88 19
M. Keith, V. Rodwell, D. Rogers, H. Rudney (1979)
In vitro phosphorylation of 3-hydroxy-3-methylglutaryl coenzyme A reductase: analysis of 32P-labeled, inactivated enzyme.Biochemical and biophysical research communications, 90 3
P. Douglas, N. Morrice, C. MacKintosh (1995)
Identification of a regulatory phosphorylation site in the hinge 1 region of nitrate reductase from spinach (Spinacea oleracea) leavesFEBS Letters, 377
J. Sullivan, K. Brocklehurst, A. Marley, F. Carey, D. Carling, R. Beri (1994)
Inhibition of lipolysis and lipogenesis in isolated rat adipocytes with AICAR, a cell‐permeable activator of AMP‐activated protein kinaseFEBS Letters, 353
M. Carlson, B. Osmond, D. Botstein (1981)
Mutants of yeast defective in sucrose utilization.Genetics, 98 1
Harald Mischak, Thomas Seitz, P. Janosch, Manfred Eulitz, Helge Steen, M. Schellerer, A. Philipp, Walter Kolch (1996)
Negative regulation of Raf-1 by phosphorylation of serine 621Molecular and Cellular Biology, 16
L. Yeh, K. Lee, K. Kim (1980)
Regulation of rat liver acetyl-CoA carboxylase. Regulation of phosphorylation and inactivation of acetyl-CoA carboxylase by the adenylate energy charge.The Journal of biological chemistry, 255 6
F. Randez-Gil, N. Bojunga, M. Proft, K. Entian (1997)
Glucose derepression of gluconeogenic enzymes in Saccharomyces cerevisiae correlates with phosphorylation of the gene activator Cat8pMolecular and Cellular Biology, 17
A. Akeson, C. Woods, L. Hsieh, R. Bohnke, B. Ackermann, Kenneth Chan, James Robinson, S. Yanofsky, Jeff Jacobs, R. Barrett, T. Bowlin (1996)
AF12198, a Novel Low Molecular Weight Antagonist, Selectively Binds the Human Type I Interleukin (IL)-1 Receptor and Blocks in Vivo Responses to IL-1*The Journal of Biological Chemistry, 271
A. Ferrer, C. Caelles, N. Massot, F. Hegardt (1987)
Affinity labeling of the catalytic and AMP allosteric sites of 3-hydroxy-3-methylglutaryl-coenzyme A reductase kinase by 5'-p-fluorosulfonylbenzoyladenosine.The Journal of biological chemistry, 262 28
B. Michell, D. Stapleton, K. Mitchelhill, C. House, Frosa Katsis, L. Witters, B. Kemp (1996)
Isoform-specific Purification and Substrate Specificity of the 5′-AMP-activated Protein Kinase*The Journal of Biological Chemistry, 271
X. Yang, E. Hubbard, M. Carlson (1992)
A protein kinase substrate identified by the two-hybrid system.Science, 257 5070
J. Gillespie, D. Hardie (1992)
Phosphorylation and inactivation of HMG‐CoA reductase at the AMP‐activated protein kinase site in response to fructose treatment of isolated rat hepatocytesFEBS Letters, 306
Z. Beg, D. Allmann, David Gibson (1973)
Modulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity with cAMP and wth protein fractions of rat liver cytosol.Biochemical and biophysical research communications, 54 4
K. Entian, F. Zimmermann (1982)
New genes involved in carbon catabolite repression and derepression in the yeast Saccharomyces cerevisiaeJournal of Bacteriology, 151
M. Stark (1996)
Yeast Protein Serine/Threonine Phosphatases: Multiple Roles and Diverse RegulationYeast, 12
M. Brown, G. Brunschede, J. Goldstein (1975)
Inactivation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in vitro. An adenine nucleotide-dependent reaction catalyzed by a factor in human fibroblasts.The Journal of biological chemistry, 250 7
J. Tu, M. Carlson (1995)
REG1 binds to protein phosphatase type 1 and regulates glucose repression in Saccharomyces cerevisiae.The EMBO Journal, 14
M. Munday, D. Campbell, D. Carling, D. Hardie (1988)
Identification by amino acid sequencing of three major regulatory phosphorylation sites on rat acetyl-CoA carboxylase.European journal of biochemistry, 175 2
S. Davies, D. Carling, D. Hardie (1989)
Tissue distribution of the AMP-activated protein kinase, and lack of activation by cyclic-AMP-dependent protein kinase, studied using a specific and sensitive peptide assay.European journal of biochemistry, 186 1-2
Z. Beg, J. Stonik, H. Brewer (1978)
3-Hydroxy-3-methylglutaryl coenzyme A reductase: regulation of enzymatic activity by phosphorylation and dephosphorylation.Proceedings of the National Academy of Sciences of the United States of America, 75 8
A. Woods, M. Munday, J. Scott, Xiaolu Yang, M. Carlson, D. Carling (1994)
Yeast SNF1 is functionally related to mammalian AMP-activated protein kinase and regulates acetyl-CoA carboxylase in vivo.The Journal of biological chemistry, 269 30
K. Ball, S. Dale, J. Weekes, D. Hardie (1994)
Biochemical characterization of two forms of 3-hydroxy-3-methylglutaryl-CoA reductase kinase from cauliflower (Brassica oleracia).European journal of biochemistry, 219 3
L. Guen, M. Thomas, M. Bianchi, Nigel Halford, M. Kreis (1992)
Structure and expression of a gene from Arabidopsis thaliana encoding a protein related to SNF1 protein kinase.Gene, 120 2
F. López‐Casillas, D. Bai, Xiaochun Luo, I. Kong, M. Hermodson, Ki‐han Kim (1988)
Structure of the coding sequence and primary amino acid sequence of acetyl-coenzyme A carboxylase.Proceedings of the National Academy of Sciences of the United States of America, 85 16
M. Bachmann, J. Huber, P. Liao, D. Gage, S. Huber (1996)
The inhibitor protein of phosphorylated nitrate reductase from spinach (Spinacia oleracea) leaves is a 14‐3‐3 proteinFEBS Letters, 387
Z. Beg, J. Stonik, H. Brewer (1979)
Characterization and regulation of reductase kinase, a protein kinase that modulates the enzymic activity of 3-hydroxy-3-methylglutaryl-coenzyme A reductase.Proceedings of the National Academy of Sciences of the United States of America, 76 9
C. Keleher, M. Redd, J. Schultz, M. Carlson, A. Johnson (1992)
Ssn6-Tup1 is a general repressor of transcription in yeastCell, 68
J. Östling, M. Carlberg, Hans Ronne (1996)
Functional domains in the Mig1 repressorMolecular and Cellular Biology, 16
M. Treitel, M. Carlson (1995)
Repression by SSN6-TUP1 is directed by MIG1, a repressor/activator protein.Proceedings of the National Academy of Sciences of the United States of America, 92
Y. Ching, S. Davies, D. Hardie (1996)
Analysis of the specificity of the AMP-activated protein kinase by site-directed mutagenesis of bacterially expressed 3-hydroxy 3-methylglutaryl-CoA reductase, using a single primer variant of the unique-site-elimination method.European journal of biochemistry, 237 3
S. Fields, O. Song (1989)
A novel genetic system to detect proteinprotein interactionsNature, 340
L. Neigeborn, M. Carlson (1987)
Mutations causing constitutive invertase synthesis in yeast: genetic interactions with snf mutations.Genetics, 115 2
J. Corton, J. Gillespie, S. Hawley, D. Hardie (1995)
5-aminoimidazole-4-carboxamide ribonucleoside. A specific method for activating AMP-activated protein kinase in intact cells?European journal of biochemistry, 229 2
D. Hardie, D. Carling, A. Sim (1989)
The AMP-activated protein kinase: a multisubstrate regulator of lipid metabolismTrends in Biochemical Sciences, 14
Michael Brown, Y. Ho, Joseph Goldstein (1980)
The cholesteryl ester cycle in macrophage foam cells. Continual hydrolysis and re-esterification of cytoplasmic cholesteryl esters.The Journal of biological chemistry, 255 19
Susan Dale, W. Wilson, A. Edelman, D. Hardie (1995)
Similar substrate recognition motifs for mammalian AMP‐activated protein kinase, higher plant HMG‐CoA reductase kinase‐A, yeast SNF1, and mammalian calmodulin‐dependent protein kinase IFEBS Letters, 361
H. Schüller, K. Entian (1988)
Molecular characterization of yeast regulatory gene CAT3 necessary for glucose derepression and nuclear localization of its product.Gene, 67 2
James Erickson, Mark Johnston (1993)
Genetic and molecular characterization of GAL83: its interaction and similarities with other genes involved in glucose repression in Saccharomyces cerevisiae.Genetics, 135 3
P. Lesage, X. Yang, M. Carlson (1994)
Analysis of the SIP3 protein identified in a two-hybrid screen for interaction with the SNF1 protein kinase.Nucleic acids research, 22 4
Rong Jiang, M. Carlson (1997)
The Snf1 protein kinase and its activating subunit, Snf4, interact with distinct domains of the Sip1/Sip2/Gal83 component in the kinase complexMolecular and Cellular Biology, 17
D. Tzamarias, Kevin Struhl (1995)
Distinct TPR motifs of Cyc8 are involved in recruiting the Cyc8-Tup1 corepressor complex to differentially regulated promoters.Genes & development, 9 7
D. Carling, V. Zammit, D. Hardie (1987)
A common bicyclic protein kinase cascade inactivates the regulatory enzymes of fatty acid and cholesterol biosynthesisFEBS Letters, 223
B. Brooks, J. Arch, E. Newsholme (1983)
Effect of some hormones on the rate of the triacylglycerol/fatty-acid substrate cycle in adipose tissue of the mouse in vivoBioscience Reports, 3
Wook Kim, A. Botchkarev, A. Salvador, G. Popovici, H. Tang, H. Morkoç (1997)
On the incorporation of Mg and the role of oxygen, silicon, and hydrogen in GaN prepared by reactive molecular beam epitaxyJournal of Applied Physics, 82
P. Goffrini, A. Ficarelli, C. Donnini, T. Lodi, P. Puglisi, I. Ferrero (1996)
FOG1 and FOG2 genes, required for the transcriptional activation of glucose-repressible genes of Kluyveromyces lactis, are homologous to GAL83 and SNF1 of Saccharomyces cerevisiaeCurrent Genetics, 29
D. Morrison, G. Heidecker, U. Rapp, T. Copeland (1993)
Identification of the major phosphorylation sites of the Raf-1 kinase.The Journal of biological chemistry, 268 23
S. Thompson-Jaeger, Jean Francois, P. Gaughran, K. Tatchell (1991)
Deletion of SNF1 affects the nutrient response of yeast and resembles mutations which activate the adenylate cyclase pathway.Genetics, 129 3
S. Yeaman (1990)
Hormone-sensitive lipase--a multipurpose enzyme in lipid metabolism.Biochimica et biophysica acta, 1052 1
D. Carling, P. Clarke, V. Zammit, D. Hardie (1989)
Purification and characterization of the AMP-activated protein kinase. Copurification of acetyl-CoA carboxylase kinase and 3-hydroxy-3-methylglutaryl-CoA reductase kinase activities.European journal of biochemistry, 186 1-2
L. Johnson, M. Noble, D. Owen (1996)
Active and Inactive Protein Kinases: Structural Basis for RegulationCell, 85
S. Davies, N. Helps, P. Cohen, D. Hardie (1995)
5′‐AMP inhibits dephosphorylation, as well as promoting phosphorylation, of the AMP‐activated protein kinase. Studies using bacterially expressed human protein phosphatase‐2Cα and native bovine protein phosphatase‐2AcFEBS Letters, 377
A. Woods, I. Salt, James Scott, D. Hardie, D. Carling (1996)
The α1 and α2 isoforms of the AMP‐activated protein kinase have similar activities in rat liver but exhibit differences in substrate specificity in vitroFEBS Letters, 397
J. Nehlin, M. Carlberg, H. Ronne (1991)
Control of yeast GAL genes by MIG1 repressor: a transcriptional cascade in the glucose response.The EMBO Journal, 10
L. Abu-Elheiga, Deysee Almarza-Ortega, A. Baldini, S. Wakil (1997)
Human Acetyl-CoA Carboxylase 2The Journal of Biological Chemistry, 272
Michael DeVit, J. Waddle, M. Johnston (1997)
Regulated nuclear translocation of the Mig1 glucose repressor.Molecular biology of the cell, 8 8
J. Chappell, F. Wolf, J. Proulx, R. Cuellar, C. Saunders (1995)
Is the Reaction Catalyzed by 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase a Rate-Limiting Step for Isoprenoid Biosynthesis in Plants?, 109
Mark Johnston, J. Flick, T. Pexton (1994)
Multiple mechanisms provide rapid and stringent glucose repression of GAL gene expression in Saccharomyces cerevisiaeMolecular and Cellular Biology, 14
B. Weis, A Cowan, N. Brown, D. Foster, J. Mcgarry (1994)
Use of a selective inhibitor of liver carnitine palmitoyltransferase I (CPT I) allows quantification of its contribution to total CPT I activity in rat heart. Evidence that the dominant cardiac CPT I isoform is identical to the skeletal muscle enzyme.The Journal of biological chemistry, 269 42
H. Flotow, P. Roach (1989)
Synergistic phosphorylation of rabbit muscle glycogen synthase by cyclic AMP-dependent protein kinase and casein kinase I. Implications for hormonal regulation of glycogen synthase.The Journal of biological chemistry, 264 16
Nigel Halford, J. Vicente-Carbajosa, P. Sabelli, P. Shewry, U. Hannappel, M. Kreis (1992)
Molecular analyses of a barley multigene family homologous to the yeast protein kinase gene SNF1Plant Journal, 2
J. Nehlin, H. Ronne (1990)
Yeast MIG1 repressor is related to the mammalian early growth response and Wilms' tumour finger proteins.The EMBO Journal, 9
Doris Hedges, M. Proft, K. Entian (1995)
CAT8, a new zinc cluster-encoding gene necessary for derepression of gluconeogenic enzymes in the yeast Saccharomyces cerevisiaeMolecular and Cellular Biology, 15
L. Neigeborn, M. Carlson (1984)
Genes affecting the regulation of SUC2 gene expression by glucose repression in Saccharomyces cerevisiae.Genetics, 108 4
R. Sato, J. Goldstein, Michael Brown (1993)
Replacement of serine-871 of hamster 3-hydroxy-3-methylglutaryl-CoA reductase prevents phosphorylation by AMP-activated kinase and blocks inhibition of sterol synthesis induced by ATP depletion.Proceedings of the National Academy of Sciences of the United States of America, 90 20
T. Ingebritsen, R. Parker, D. Gibson (1981)
Regulation of liver hydroxymethylglutaryl-CoA reductase by a bicyclic phosphorylation system.The Journal of biological chemistry, 256 3
S. Huber, J. Huber (1996)
ROLE AND REGULATION OF SUCROSE-PHOSPHATE SYNTHASE IN HIGHER PLANTS.Annual review of plant physiology and plant molecular biology, 47
Rong Jiang, Marian Carlson (1996)
Glucose regulates protein interactions within the yeast SNF1 protein kinase complex.Genes & development, 10 24
R. Mackintosh, S. Davies, P. Clarke, J. Weekes, J. Gillespie, Barry Gibb, D. Hardie (1992)
Evidence for a protein kinase cascade in higher plants. 3-Hydroxy-3-methylglutaryl-CoA reductase kinase.European journal of biochemistry, 209 3
R. Arebalo, J. Hardgrave, T. Scallen (1981)
The in vivo regulation of rat liver 3-hydroxy-3-methylglutaryl coenzyme A reductase. Phosphorylation of the enzyme as an early regulatory response following cholesterol feeding.The Journal of biological chemistry, 256 2
J. McGarry, Y. Takabayashi, D. Foster (1978)
The role of malonyl-coa in the coordination of fatty acid synthesis and oxidation in isolated rat hepatocytes.The Journal of biological chemistry, 253 22
R. McMichael, Markus Bachmann, S. Huber (1995)
Spinach Leaf Sucrose-Phosphate Synthase and Nitrate Reductase Are Phosphorylated/Inactivated by Multiple Protein Kinases in Vitro, 108
Markus Bachmann, N. Shiraishi, Wilbur Campbell, Byung-Chun Yoo, Alice Harmon, S. Huber (1996)
Identification of Ser-543 as the major regulatory phosphorylation site in spinach leaf nitrate reductase.The Plant cell, 8
P. Clarke, D. Hardie (1990)
Regulation of HMG‐CoA reductase: identification of the site phosphorylated by the AMP‐activated protein kinase in vitro and in intact rat liver.The EMBO Journal, 9
R. Michael, Munday, M. Milic, Sarvjinder Takhar, Mark HOLNESSt, Mary SUGDENt (1991)
The short-term regulation of hepatic acetyl-CoA carboxylase during starvation and re-feeding in the rat.The Biochemical journal, 280 ( Pt 3)
▪ Abstract Mammalian AMP-activated protein kinase and yeast SNF1 protein kinase are the central components of kinase cascades that are highly conserved between animals, fungi, and plants. The AMP-activated protein kinase cascade acts as a metabolic sensor or “fuel gauge” that monitors cellular AMP and ATP levels because it is activated by increases in the AMP:ATP ratio. Once activated, the enzyme switches off ATP-consuming anabolic pathways and switches on ATP-producing catabolic pathways, such as fatty acid oxidation. The SNF1 complex in yeast is activated in response to the stress of glucose deprivation. In this case the intracellular signal or signals have not been identified; however, SNF1 activation is associated with depletion of ATP and elevation of AMP. The SNF1 complex acts primarily by inducing expression of genes required for catabolic pathways that generate glucose, probably by triggering phosphorylation of transcription factors. SNF1-related protein kinases in higher plants are likely to be involved in the response of plant cells to environmental and/or nutritional stress.
Annual Review of Biochemistry – Annual Reviews
Published: Jul 1, 1998
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.