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Glucocorticoid therapy and equine laminitis: fact or fiction?

Glucocorticoid therapy and equine laminitis: fact or fiction? Glucocorticoid therapy and equine laminitis: fact or fiction? C. J. CORNELISSE AND N. E. ROBINSON* Pulmonary Laboratory, Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan 48824, USA. Keywords: horse; laminitis; glucocorticoids; triamcinolone acetonide Introduction Is administration of glucocorticoids associated with laminitis in horses? That is the core question posed by McCluskey and Kavenagh (2004) on p 86 of this issue regarding the prevalence of equine laminitis after parenteral treatment of 205 horses with triamcinolone acetonide (TMC). Is there clinical evidence for the connection between glucocorticoids and laminitis? Since the introduction of glucocorticoids into equine medicine more than 30 years ago, their use has been accompanied by fear of induction of laminitis. Despite this fear, real information regarding glucocorticoid use and laminitis is scarce. In a small number of reports in the older veterinary and lay literature, an association between laminitis and prior glucocorticoid use was implied, but it was not possible to definitively prove this association. For instance, some reports included horses with chronic obstructive pulmonary disease (Gerber 1970; Muylle and Oyaert 1973), animals that are usually older and could have had Cushing’s disease. Horses in other reports may have http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Equine Veterinary Education Wiley

Glucocorticoid therapy and equine laminitis: fact or fiction?

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References (57)

Publisher
Wiley
Copyright
2004 EVJ Ltd
ISSN
0957-7734
eISSN
2042-3292
DOI
10.1111/j.2042-3292.2004.tb00273.x
Publisher site
See Article on Publisher Site

Abstract

Glucocorticoid therapy and equine laminitis: fact or fiction? C. J. CORNELISSE AND N. E. ROBINSON* Pulmonary Laboratory, Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan 48824, USA. Keywords: horse; laminitis; glucocorticoids; triamcinolone acetonide Introduction Is administration of glucocorticoids associated with laminitis in horses? That is the core question posed by McCluskey and Kavenagh (2004) on p 86 of this issue regarding the prevalence of equine laminitis after parenteral treatment of 205 horses with triamcinolone acetonide (TMC). Is there clinical evidence for the connection between glucocorticoids and laminitis? Since the introduction of glucocorticoids into equine medicine more than 30 years ago, their use has been accompanied by fear of induction of laminitis. Despite this fear, real information regarding glucocorticoid use and laminitis is scarce. In a small number of reports in the older veterinary and lay literature, an association between laminitis and prior glucocorticoid use was implied, but it was not possible to definitively prove this association. For instance, some reports included horses with chronic obstructive pulmonary disease (Gerber 1970; Muylle and Oyaert 1973), animals that are usually older and could have had Cushing’s disease. Horses in other reports may have

Journal

Equine Veterinary EducationWiley

Published: Apr 1, 2004

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