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Mark Wall, M. Usowicz (1997)
Development of Action Potential‐dependent and Independent Spontaneous GABAA Receptor‐mediated Currents in Granule Cells of Postnatal Rat CerebellumEuropean Journal of Neuroscience, 9
J. Eccles (1963)
Postsynaptic and Presynaptic Inhibitory Actions in the Spinal CordProgress in Brain Research, 1
E. Desaulles, O. Boux, P. Feltz (1991)
Caffeine-induced Ca2+ release inhibits GABAA responsiveness in rat identified native primary afferents.European journal of pharmacology, 203 1
B. Hille, J. Billiard, D. Babcock, Toan Nguyen, D. Koh (1999)
Stimulation of exocytosis without a calcium signalThe Journal of Physiology, 520
Corey Corey, Davidson Davidson, Lester Lester, Brecha Brecha, Quick Quick (1994)
Protein kinase C modulates the activity of a cloned GABA transporter expressed in Xenopus oocytes via regulated subcellular redistribution of the transporterJ Biol Chem, 269
Mathew Jones, Y. Sahara, J. Dzubay, G. Westbrook (1998)
Defining Affinity with the GABAA ReceptorThe Journal of Neuroscience, 18
Fong-Sen Wu, T. Gibbs, D. Farb (1993)
Dual activation of GABAA and glycine receptors by β-alanine : inverse modulation by progesterone and 5α-pregnan-3α-ol-20-oneEuropean Journal of Pharmacology, 246
C. Léna, J. Changeux (1997)
Role of Ca2+ Ions in Nicotinic Facilitation of GABA Release in Mouse ThalamusThe Journal of Neuroscience, 17
G. Richerson, C. Messer (1995)
Effect of composition of experimental solutions on neuronal survival during rat brain slicingExperimental Neurology, 131
S. Kirischuk, N. Voitenko, P. Kostyuk, A. Verkhratsky (1996)
Calcium signalling in granule neurones studied in cerebellar slices.Cell calcium, 19 1
E. Toro, J. Juiz, Xiao-song Peng, J. Lindstrom, M. Criado (2004)
Acetylcholine Receptor in the Rat Central Nervous System
(2000)
Persistent Activation of GABAA Receptor/Cl
Z. Nusser, W. Sieghart, P. Somogyi (1998)
Segregation of Different GABAA Receptors to Synaptic and Extrasynaptic Membranes of Cerebellar Granule CellsThe Journal of Neuroscience, 18
D. Laurie, W. Wisden, P. Seeburg (1992)
The distribution of thirteen GABAA receptor subunit mRNAs in the rat brain. III. Embryonic and postnatal development, 12
M. Hasselmo (1999)
Neuromodulation: acetylcholine and memory consolidationTrends in Cognitive Sciences, 3
D. Attwell, B. Barbour, M. Szatkowski (1993)
Nonvesicular release of neurotransmitterNeuron, 11
M. Achtman, K. James, S. Bentley, C. Churcher, S. Klee, G. Morelli, D. Basham, D. Brown, T. Chillingworth, R. Davies, P. Davis, K. Devlin, T. Feltwell, N. Hamlin, S. Holroyd, K. Jagels, S. Leather, S. Moule, K. Mungall, M. Quail, K. Rutherford, M. Simmonds, J. Skelton, S. Whitehead, B. Spratt, B. Barrell (2000)
Glutamate spillover suppresses inhibition by activating presynaptic mGluRsNature, 404
S. Tia, Jin Wang, N. Kotchabhakdi, S. Vicini (1996)
Developmental Changes of Inhibitory Synaptic Currents in Cerebellar Granule Neurons: Role of GABAA Receptor α6 SubunitThe Journal of Neuroscience, 16
D. Jaarsma, T. Ruigrok, R. Caffé, C. Cozzari, A. Levey, E. Mugnaini, J. Voogd (1997)
Cholinergic innervation and receptors in the cerebellum.Progress in brain research, 114
H. Gaspary, W. Wang, G. Richerson (1998)
Carrier-mediated GABA release activates GABA receptors on hippocampal neurons.Journal of neurophysiology, 80 1
D. Rossi, T. Oshima, D. Attwell (2000)
Glutamate release in severe brain ischaemia is mainly by reversed uptakeNature, 403
D. DiGregorio, Z. Nusser, R. Silver (2002)
Spillover of Glutamate onto Synaptic AMPA Receptors Enhances Fast Transmission at a Cerebellar SynapseNeuron, 35
Denis Jabaudon, K. Shimamoto, Y. Yasuda‐Kamatani, Massimo Scanziani, B. Gähwiler, Urs Gerber (1999)
Inhibition of uptake unmasks rapid extracellular turnover of glutamate of nonvesicular origin.Proceedings of the National Academy of Sciences of the United States of America, 96 15
T. Tyrrell, D. Willshaw (1992)
Cerebellar cortex: its simulation and the relevance of Marr's theory.Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 336 1277
J. Hámori, J. Somogyi (1983)
Differentiation of cerebellar mossy fiber synapses in the rat: A quantitative electron microscope studyJournal of Comparative Neurology, 220
S. Korn, R. Dingledine (1986)
Inhibition of GABA uptake in the rat hippocampal sliceBrain Research, 368
E. Korpi, T. Kuner, P. Seeburg, H. Lüddens (1995)
Selective antagonist for the cerebellar granule cell-specific gamma-aminobutyric acid type A receptor.Molecular pharmacology, 47 2
B. Katz, R. Miledi (1977)
Transmitter leakage from motor nerve endingsProceedings of the Royal Society of London. Series B. Biological Sciences, 196
Qi‐Ying Liu, A. Schaffner, Y. Chang, D. Maric, J. Barker (2000)
Persistent Activation of GABAAReceptor/Cl− Channels by Astrocyte-Derived GABA in Cultured Embryonic Rat Hippocampal NeuronsJournal of Neurophysiology, 84
D. Jaarsma, T. Ruigrok, R. Caffé, C. Cozzari, A. Levey, E. Mugnaini, J. Voogd (1997)
Chapter 5 Cholinergic innervation and receptors in the cerebellumProgress in Brain Research, 114
Toro Toro, Juiz Juiz, Peng Peng, Lindstrom Lindstrom, Criado Criado (1994)
Immunocytochemical localization of the α 7 subunit of the nicotinic acetylcholine receptor in the rat central nervous systemJ Comp Neurol, 349
S. Brickley, V. Revilla, S. Cull-Candy, W. Wisden, M. Farrant (2001)
Adaptive regulation of neuronal excitability by a voltage- independent potassium conductanceNature, 409
S. Brickley, S. Cull-Candy, M. Farrant (1996)
Development of a tonic form of synaptic inhibition in rat cerebellar granule cells resulting from persistent activation of GABAA receptors.The Journal of Physiology, 497
S. Morara, N. Brecha, Walter Provini, A. Rosina (1996)
Neuronal and glial localization of the GABA transporter GAT‐1 in the cerebellar cortexNeuroReport, 7
A. Irving, G. Collingridge, J. Schofield (1992)
Interactions between Ca2+ mobilizing mechanisms in cultured rat cerebellar granule cells.The Journal of Physiology, 456
H. Parnas, L. Segel, J. Dudel, I. Parnas (2000)
Autoreceptors, membrane potential and the regulation of transmitter releaseTrends in Neurosciences, 23
R. Maex, E. Schutter (1998)
Synchronization of golgi and granule cell firing in a detailed network model of the cerebellar granule cell layer.Journal of neurophysiology, 80 5
C. Zhang, Z. Zhou (2002)
Ca(2+)-independent but voltage-dependent secretion in mammalian dorsal root ganglion neurons.Nature neuroscience, 5 5
Qing-Rong Liu, Beatriz Lopez-Corcueral, S. Mandiyan, H. Nelson, Nathan Nelsons (2001)
Molecular Characterization of Four Pharmacologically Distinct a-Aminobutyric Acid Transporters in Mouse Brain *
S. Dröse, K. Altendorf (1997)
Bafilomycins and concanamycins as inhibitors of V-ATPases and P-ATPases.The Journal of experimental biology, 200 Pt 1
A. Akopian, R. Gábriel, P. Witkovsky (1998)
Calcium released from intracellular stores inhibits GABAA-mediated currents in ganglion cells of the turtle retina.Journal of neurophysiology, 80 3
Q Liu, B. López-Corcuera, S. Mandiyan, H. Nelson, N. Nelson (1993)
Molecular characterization of four pharmacologically distinct gamma-aminobutyric acid transporters in mouse brain [corrected].The Journal of biological chemistry, 268 3
D. Marr (1969)
A theory of cerebellar cortexThe Journal of Physiology, 202
Yuanming Wu, Wengang Wang, G. Richerson (2001)
GABA Transaminase Inhibition Induces Spontaneous and Enhances Depolarization-Evoked GABA Efflux via Reversal of the GABA TransporterThe Journal of Neuroscience, 21
E. Schwartz (1987)
Depolarization without calcium can release gamma-aminobutyric acid from a retinal neuron.Science, 238 4825
R. Illing (1990)
A subtype of cerebellar Golgi cells may be cholinergicBrain Research, 522
Zhong-wei Zhang, P. Feltz (1991)
Bicuculline blocks nicotinic acetylcholine response in isolated intermediate lobe cells of the pigBritish Journal of Pharmacology, 102
F. Wu, T. Gibbs, D. Farb (1993)
Dual activation of GABAA and glycine receptors by beta-alanine: inverse modulation by progesterone and 5 alpha-pregnan-3 alpha-ol-20-one.European journal of pharmacology, 246 3
D. Rossi, M. Hamann (1998)
Spillover-Mediated Transmission at Inhibitory Synapses Promoted by High Affinity α6 Subunit GABAA Receptors and Glomerular GeometryNeuron, 20
D. Laurie, P. Seeburg, W. Wisden (1992)
The distribution of 13 GABAA receptor subunit mRNAs in the rat brain. II. Olfactory bulb and cerebellum, 12
S. Lacalle, L. Hersh, C. Saper (1993)
Cholinergic innervation of the human cerebellumJournal of Comparative Neurology, 328
E. Rutledge, H. Kimelberg (1996)
Release of [3H]-d-Aspartate from Primary Astrocyte Cultures in Response to Raised External PotassiumThe Journal of Neuroscience, 16
L. Borden, T. Dhar, Kelli Smith, R. Weinshank, T. Branchek, C. Gluchowski (1994)
Tiagabine, SK&F 89976-A, CI-966, and NNC-711 are selective for the cloned GABA transporter GAT-1.European journal of pharmacology, 269 2
Janis Corey, Norman Davidson, Henry Lester, N. Brecha, Michael Quick (1994)
Protein kinase C modulates the activity of a cloned gamma-aminobutyric acid transporter expressed in Xenopus oocytes via regulated subcellular redistribution of the transporter.The Journal of biological chemistry, 269 20
N. Saxena, R. Macdonald (1996)
Properties of putative cerebellar gamma-aminobutyric acid A receptor isoforms.Molecular pharmacology, 49 3
T. Neelands, Janet Fisher, M. Bianchi, Robert Macdonald (1999)
Spontaneous and gamma-aminobutyric acid (GABA)-activated GABA(A) receptor channels formed by epsilon subunit-containing isoforms.Molecular pharmacology, 55 1
E. Schutter (2002)
Cerebellar Cortex: Computation by Extrasynaptic Inhibition?Current Biology, 12
H. Pasantes‐morales, L. Paz, J. Sepúlveda, O. Quesada (1999)
Amino Acids as Osmolytes in the RetinaNeurochemical Research, 24
M. Hamann, D. Rossi, D. Attwell (2002)
Tonic and Spillover Inhibition of Granule Cells Control Information Flow through Cerebellar CortexNeuron, 33
J. Eccles, R. Llinás, K. Sasaki (2004)
The inhibitory interneurones within the cerebellar cortexExperimental Brain Research, 1
J. Olson, H. Kimelberg (1995)
Hypoosmotic volume regulation and osmolyte transport in astrocytes is blocked by an anion transport inhibitor, L-644,711Brain Research, 682
Mark Wall (2002)
Furosemide reveals heterogeneous GABAA receptor expression at adult rat Golgi cell to granule cell synapsesNeuropharmacology, 43
J. Mellor, M. Gunthorpe, Andrew Randall (2000)
The taurine uptake inhibitor guanidinoethyl sulphonate is an agonist at γ-aminobutyric acidA receptors in cultured murine cerebellar granule cellsNeuroscience Letters, 286
Susan Jones, J. Yakel (1997)
Functional nicotinic ACh receptors on interneurones in the rat hippocampusThe Journal of Physiology, 504
D. Rossi, N. Slater (1993)
The developmental onset of NMDA receptor-channel activity during neuronal migrationNeuropharmacology, 32
Qiang Zhou, C. Petersen, R. Nicoll (2000)
Effects of reduced vesicular filling on synaptic transmission in rat hippocampal neuronesThe Journal of Physiology, 525
Makoto Kaneda, M. Farrant, S. Cull-Candy (1995)
Whole‐cell and single‐channel currents activated by GABA and glycine in granule cells of the rat cerebellum.The Journal of Physiology, 485
J. Kemp, G. Marshall, G. Woodruff (1986)
Quantitative evaluation of the potencies of GABA‐receptor agonists and antagonists using the rat hippocampal slice preparationBritish Journal of Pharmacology, 87
H. Nakayama, S. Shioda, S. Nakajo, S. Ueno, T. Nakashima, Y. Nakai (1997)
Immunocytochemical localization of nicotinic acetylcholine receptor in the rat cerebellar cortexNeuroscience Research, 29
A. Itouji, N. Sakai, C. Tanaka, N. Saito (1996)
Neuronal and glial localization of two GABA transporters (GAT1 and GAT3) in the rat cerebellum.Brain research. Molecular brain research, 37 1-2
Hamann Hamann, Rossi Rossi, Attwell Attwell (2002)
Tonic and spillover inhibition control information flow through cerebellar cortexNeuron, 33
L. Barakat, A. Bordey (2002)
GAT-1 and reversible GABA transport in Bergmann glia in slices.Journal of neurophysiology, 88 3
H. Kimelberg, SK Goderie, S. Higman, S. Pang, RA Waniewski (1990)
Swelling-induced release of glutamate, aspartate, and taurine from astrocyte cultures, 10
Tsukasa Manabe, T. Yoshimori, N. Henomatsu, Y. Tashiro (1993)
Inhibitors of vacuolar‐type H+‐ATPase suppresses proliferation of cultured cellsJournal of Cellular Physiology, 157
Cerebellar granule cells are inhibited phasically by GABA released synaptically from Golgi cells, but are inhibited more powerfully by tonic activity of high affinity α6 subunit‐containing GABAA receptors. During development the tonic activity is generated by the accumulation of GABA released by action potentials, but in the adult the tonic activity is independent of action potentials. Here we show that in adult rats the tonic activation of GABAA receptors is produced by non‐vesicular transmitter release and is reduced by the activity of GAT‐1 and GAT‐3 GABA transporters, demonstrating that alterations of GABA uptake will modulate information flow through granule cells. Acetylcholine (ACh) evokes a large Ca2+‐dependent but action potential‐independent release of GABA, which activates α6 subunit‐containing GABAA receptors. These data show that three separate modes of transmitter release can activate GABAA receptors in adult cerebellar granule cells: action potential‐evoked exocytotic GABA release, non‐vesicular release, and ACh‐evoked Ca2+‐dependent release independent of action potentials. The relative magnitudes of the inhibitory charge transfers generated by action potential‐evoked release (during high frequency stimulation of the mossy fibres), tonic inhibition and superfused ACh are 1:3:12, indicating that tonic and ACh‐mediated inhibition may play a major role in regulating granule cell firing.
The Journal of Physiology – Wiley
Published: Apr 1, 2003
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