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Chronic imipramine treatment normalizes levels of tyrosine hydroxylase in the locus coeruleus of chronically stressed rats

Chronic imipramine treatment normalizes levels of tyrosine hydroxylase in the locus coeruleus of... 213 108 108 1 2 Kathleen R. Melia Eric J. Nestler Ronald S. Duman Laboratory of Molecular Psychiatry, Department of Psychiatry Yale University School of Medicine and the Ribicoff Research Facilities of the Connecticut Mental Health Center 34 Park Street 06508 New Haven CT USA Abstract Previous studies have demonstrated that chronic stress increases and antidepressant treatments decrease levels of tyrosine hydroxylase (TH) in locus coeruleus (LC). In the present study, the influence of chronic antidepressant treatment on the induction of TH immunoreactivity in response to cold stress is examined. It was found that chronic imipramine pretreatment (18 days) attenuated the induction of TH in response to cold stress, resulting in levels of TH immunoreactivity not different from control. In contrast, imipramine pretreatment for 1 or 7 days was not sufficient to normalize the stress-induced elevation of TH immunoreactivity. These findings raise the possibility that the therapeutic action of antidepressants may be derived, in part, from the ability of these treatments to normalize levels of TH and thereby the function of the NE neurotransmitter system under conditions of stress. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Psychopharmacology Springer Journals

Chronic imipramine treatment normalizes levels of tyrosine hydroxylase in the locus coeruleus of chronically stressed rats

Melia, Kathleen; Nestler, Eric; Duman, Ronald
Psychopharmacology , Volume 108 (1) – Jul 1, 1992
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References (38)

Publisher
Springer Journals
Copyright
Copyright © 1992 by Springer-Verlag
Subject
Biomedicine; Pharmacology/Toxicology; Psychiatry
ISSN
0033-3158
eISSN
1432-2072
DOI
10.1007/BF02245280
Publisher site
See Article on Publisher Site

Abstract

213 108 108 1 2 Kathleen R. Melia Eric J. Nestler Ronald S. Duman Laboratory of Molecular Psychiatry, Department of Psychiatry Yale University School of Medicine and the Ribicoff Research Facilities of the Connecticut Mental Health Center 34 Park Street 06508 New Haven CT USA Abstract Previous studies have demonstrated that chronic stress increases and antidepressant treatments decrease levels of tyrosine hydroxylase (TH) in locus coeruleus (LC). In the present study, the influence of chronic antidepressant treatment on the induction of TH immunoreactivity in response to cold stress is examined. It was found that chronic imipramine pretreatment (18 days) attenuated the induction of TH in response to cold stress, resulting in levels of TH immunoreactivity not different from control. In contrast, imipramine pretreatment for 1 or 7 days was not sufficient to normalize the stress-induced elevation of TH immunoreactivity. These findings raise the possibility that the therapeutic action of antidepressants may be derived, in part, from the ability of these treatments to normalize levels of TH and thereby the function of the NE neurotransmitter system under conditions of stress.

Journal

Psychopharmacology – Springer Journals

Published: Jul 1, 1992

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