Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Intelligent micellar polymeric nanocarriers for therapeutics and diagnosis

Intelligent micellar polymeric nanocarriers for therapeutics and diagnosis Polymeric micelles can be designed and synthesized to bear polymeric blocks with different hydrophilicities; this triggers their self‐assembly into micellar aggregates similar to those generated with traditional surfactants. The basic structure consists of a hydrophobic core, capable of containing guest substances, and a hydrophilic shell, which stabilizes the payload and protects it from external degradation or prevents its quick elimination from the body. The accumulation of block copolymer micelles (BCMs) in a target cell or tissue can be accomplished by two main mechanisms, passive and active targeting; this allows the payload release at the site of action when desired. Hence, in this general overview, we pay special attention to newly developed single‐stimulus‐ and multi‐stimuli‐responsive delivery systems capable of disassembling and reassembling (in some cases) as a response to changes in their physicochemical properties. Also, special interest is also devoted to multifunctional BCMs incorporating multiple therapeutic agents and/or multiple imaging contrast agents, which can be considered the new generation (third generation) of drug‐delivery systems, that is, nanotheranostic platforms. Finally, a summary of BCM‐based drug‐delivery systems currently under clinical trials is given. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 42650. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Applied Polymer Science Wiley

Intelligent micellar polymeric nanocarriers for therapeutics and diagnosis

Download PDF
18 pages

Loading next page...
 
/lp/wiley/intelligent-micellar-polymeric-nanocarriers-for-therapeutics-and-JJ0K5HuC0Y

References (171)

Publisher
Wiley
Copyright
"© 2015 Wiley Periodicals, Inc."
ISSN
0021-8995
eISSN
1097-4628
DOI
10.1002/app.42650
Publisher site
See Article on Publisher Site

Abstract

Polymeric micelles can be designed and synthesized to bear polymeric blocks with different hydrophilicities; this triggers their self‐assembly into micellar aggregates similar to those generated with traditional surfactants. The basic structure consists of a hydrophobic core, capable of containing guest substances, and a hydrophilic shell, which stabilizes the payload and protects it from external degradation or prevents its quick elimination from the body. The accumulation of block copolymer micelles (BCMs) in a target cell or tissue can be accomplished by two main mechanisms, passive and active targeting; this allows the payload release at the site of action when desired. Hence, in this general overview, we pay special attention to newly developed single‐stimulus‐ and multi‐stimuli‐responsive delivery systems capable of disassembling and reassembling (in some cases) as a response to changes in their physicochemical properties. Also, special interest is also devoted to multifunctional BCMs incorporating multiple therapeutic agents and/or multiple imaging contrast agents, which can be considered the new generation (third generation) of drug‐delivery systems, that is, nanotheranostic platforms. Finally, a summary of BCM‐based drug‐delivery systems currently under clinical trials is given. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 42650.

Journal

Journal of Applied Polymer Science – Wiley

Published: May 5, 2015

Keywords: ; ; ; ;

There are no references for this article.