Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Effects of NO synthase inhibition on the muscular blood flow response to treadmill exercise in rats

Effects of NO synthase inhibition on the muscular blood flow response to treadmill exercise in rats Hirai, Tadakazu, Mark D. Visneski, Kevin J. Kearns, Robert Zelis, and Timothy I. Musch. Effects of on the muscular blood flow response to treadmill in rats. J. Appl. Physiol. 77(3): 1288-1293, 1994.The functional role of nitric oxide () release in regulating blood flow (BF) to exercising skeletal muscle was studied in conscious male Sprague-Dawley rats (603 t 28 g; n = 6). In this study, BF was measured using radiolabeled microspheres treadmill (10% grade, 20 m/min) before and after (S) with NG-nitro-L-arginine methyl ester (30 mg/kg ia). After S , mean arterial blood pressure increased from resting baseline values and the duration of vasodilator responses to acetylcholine (ACh) injections (3.0 and 10.0 pg/kg ia) was diminished (P < 0.05), demonstrating reduced S function. , BF to the kidneys and organs of the gut was reduced after S . In addition, BF was reduced in 16 of the 28 individual hindquarter muscles or muscle parts. Moreover these reductions in BF were linearly correlated with the estimated sum of the percentage of fast-twitch oxidative glycolytic (FOG) and slow-twitch oxidative (SO) types of fibers found in each muscle [ABF = -l.l(%SO + %FOG) + 16.4; r = 0.88, P < O.OOl]. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Applied Physiology The American Physiological Society

Effects of NO synthase inhibition on the muscular blood flow response to treadmill exercise in rats

Loading next page...
 
/lp/the-american-physiological-society/effects-of-no-synthase-inhibition-on-the-muscular-blood-flow-response-I0yrFwGJlP

References

References for this paper are not available at this time. We will be adding them shortly, thank you for your patience.

Publisher
The American Physiological Society
Copyright
Copyright © 1994 the American Physiological Society
ISSN
8750-7587
eISSN
1522-1601
Publisher site
See Article on Publisher Site

Abstract

Hirai, Tadakazu, Mark D. Visneski, Kevin J. Kearns, Robert Zelis, and Timothy I. Musch. Effects of on the muscular blood flow response to treadmill in rats. J. Appl. Physiol. 77(3): 1288-1293, 1994.The functional role of nitric oxide () release in regulating blood flow (BF) to exercising skeletal muscle was studied in conscious male Sprague-Dawley rats (603 t 28 g; n = 6). In this study, BF was measured using radiolabeled microspheres treadmill (10% grade, 20 m/min) before and after (S) with NG-nitro-L-arginine methyl ester (30 mg/kg ia). After S , mean arterial blood pressure increased from resting baseline values and the duration of vasodilator responses to acetylcholine (ACh) injections (3.0 and 10.0 pg/kg ia) was diminished (P < 0.05), demonstrating reduced S function. , BF to the kidneys and organs of the gut was reduced after S . In addition, BF was reduced in 16 of the 28 individual hindquarter muscles or muscle parts. Moreover these reductions in BF were linearly correlated with the estimated sum of the percentage of fast-twitch oxidative glycolytic (FOG) and slow-twitch oxidative (SO) types of fibers found in each muscle [ABF = -l.l(%SO + %FOG) + 16.4; r = 0.88, P < O.OOl].

Journal

Journal of Applied PhysiologyThe American Physiological Society

Published: Sep 1, 1994

There are no references for this article.