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T. Jindo, R. Imai, R. Tsuboi, K. Takamori, H. Ogawa (1994)
The effect of various cytokines on hair growth of mouse vibrissae in organ culture.Journal of dermatological science, 7 Suppl
Per Lindahl, Mats Hellström, M. Kalén, Christer Betsholtz (1998)
Endothelial-perivascular cell signaling in vascular development: lessons from knockout mice.Current opinion in lipidology, 9 5
Masashi Akiyama, L. Smith, Karen Holbrook (1996)
Growth factor and growth factor receptor localization in the hair follicle bulge and associated tissue in human fetus.The Journal of investigative dermatology, 106 3
C. Jahoda, C. Jahoda, K. Horne, R. Oliver (1984)
Induction of hair growth by implantation of cultured dermal papilla cellsNature, 311
U. Kozlowska, U. Blume-Peytavi, V. Kodelja, C. Sommer, S. Goerdt, S. Majewski, S. Jabłońska, C. Orfanos (1998)
Expression of vascular endothelial growth factor (VEGF) in various compartments of the human hair follicleArchives of Dermatological Research, 290
P. Campochiaro, S. Hackett, S. Vinores, J. Freund, C. Csaky, W. Larochelle, Jeff Henderer, Mike Johnson, Ignacio Rodriguez, Z. Friedman, N. Derevjanik, J. Dooner (1994)
Platelet-derived growth factor is an autocrine growth stimulator in retinal pigmented epithelial cells.Journal of cell science, 107 ( Pt 9)
Gina Taylor, M. Lehrer, P. Jensen, T. Sun, R. Lavker (2000)
Involvement of Follicular Stem Cells in Forming Not Only the Follicle but Also the EpidermisCell, 102
G. Cotsarelis, T. Sun, R. Lavker (1990)
Label-retaining cells reside in the bulge area of pilosebaceous unit: Implications for follicular stem cells, hair cycle, and skin carcinogenesisCell, 61
C. Jahoda, A. Reynolds (2001)
Hair follicle dermal sheath cells: unsung participants in wound healingThe Lancet, 358
L. Karlsson, Cecilia Bondjers, Christer Betsholtz (1999)
Roles for PDGF-A and sonic hedgehog in development of mesenchymal components of the hair follicle.Development, 126 12
K. Forsberg, Istvan VALYI-NAGYt, C. Heldin, Meenhard HERLYNt, B. Westermark (1993)
Platelet-derived growth factor (PDGF) in oncogenesis: development of a vascular connective tissue stroma in xenotransplanted human melanoma producing PDGF-BB.Proceedings of the National Academy of Sciences of the United States of America, 90
L. Goodman, S. Ledbetter (1992)
Secretion of stromelysin by cultured dermal papilla cells: Differential regulation by growth factors and functional role in mitogen‐induced cell proliferationJournal of Cellular Physiology, 151
J. Kishimoto, R. Ehama, L. Wu, S. Jiang, N. Jiang, R. Burgeson (1999)
Selective activation of the versican promoter by epithelial- mesenchymal interactions during hair follicle development.Proceedings of the National Academy of Sciences of the United States of America, 96 13
A. Reynolds, C. Jahoda (1991)
Hair follicle stem cells? A distinct germinative epidermal cell population is activated in vitro by the presence of hair dermal papilla cells.Journal of cell science, 99 ( Pt 2)
U. Blume-Peytavi, N. Mandt (2000)
Signalling molecules in human hair follicle cell populationsp
Y. Xiong, C. Harmon (1997)
Interleukin-1beta is differentially expressed by human dermal papilla cells in response to PKC activation and is a potent inhibitor of human hair follicle growth in organ culture.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, 17 3
C. Betsholtz, L. Karlsson, P. Lindahl (2001)
Developmental roles of platelet‐derived growth factorsBioEssays, 23
Jui-Chang Tsai, C. Goldman, G. Gillespie (1995)
Vascular endothelial growth factor in human glioma cell lines: induced secretion by EGF, PDGF-BB, and bFGF.Journal of neurosurgery, 82 5
Julic Little, K. Redwood, S. Granger, G. Jenkins (1996)
In vivo cytokine and receptor gene expression during the rat hair growth cycleExperimental Dermatology, 5
R. Lavker, Stanley Miller, Caroline Wilson, G. Cotsarelis, Zhiqian Wei, Jing Yang, Tung-Tien Sun (1993)
Hair follicle stem cells: their location, role in hair cycle, and involvement in skin tumor formation.The Journal of investigative dermatology, 101 1 Suppl
K. Plate, G. Breier, Farrell Cl, W. Risau (1992)
Platelet-derived growth factor receptor-beta is induced during tumor development and upregulated during tumor progression in endothelial cells in human gliomas.Laboratory investigation; a journal of technical methods and pathology, 67 4
N. Takakura, H. Yoshida, T. Kunisada, S. Nishikawa, S. Nishikawa (1996)
Involvement of platelet-derived growth factor receptor-alpha in hair canal formation.The Journal of investigative dermatology, 107 5
A. Reynolds, C. Lawrence, P. Cserhalmi-Friedman, A. Christiano, C. Jahoda (1999)
Trans-gender induction of hair folliclesNature, 402
Hoffmann Hoffmann, Eicheler Eicheler, Huth Huth, Wenzel Wenzel, Happle Happle (1996)
Cytokines and growth factors influence hair growth in vitro. Possible implications for the pathogenesis and treatment of alopecia areataArch Dermatol Res, 288
Little Little, Redwood Redwood, Granger Granger, Jenkins Jenkins (1996)
In vivo cytokine and receptor gene expression during the rat hair growth cycle. Analysis by semi‐quantitative RT‐PCRExp Dermatol, 5
M. Detmar, F. Schaart, U. Blume, C. Orfanos (1993)
Culture of hair matrix and follicular keratinocytes.The Journal of investigative dermatology, 101 1 Suppl
R. Rückert, G. Lindner, S. Bulfone-Paus, R. Paus (2000)
High‐dose proinflammatory cytokines induce apoptosis of hair bulb keratinocytes in vivoBritish Journal of Dermatology, 143
M. Philpott, D. Sanders, J. Bowen, T. Kealey (1996)
Effects of interleukins, colony‐stimulating factor and tumour necrosis factor on human hair follicle growth in vitro: a possible role for interleukin‐1 and tumour necrosis factor‐α in alopecia areataBritish Journal of Dermatology, 135
M. Philpott, D. Sanders, T. Kealey (1996)
Whole hair follicle culture.Dermatologic clinics, 14 4
A. Siegbahn, A. Hammacher, B. Westermark, C. Heldin (1990)
Differential effects of the various isoforms of platelet-derived growth factor on chemotaxis of fibroblasts, monocytes, and granulocytes.The Journal of clinical investigation, 85 3
W. Larochelle, M. Jeffers, W. McDonald, R. Chillakuru, N. Giese, N. Lokker, Carol Sullivan, F. Boldog, Meijia Yang, C. Vernet, C. Burgess, E. Fernandes, Lisa Deegler, B. Rittman, Juliette Shimkets, R. Shimkets, J. Rothberg, H. Lichenstein (2001)
PDGF-D, a new protease-activated growth factorNature Cell Biology, 3
A. Abbott (1999)
Framework funding ban hits mouse mutant archiveNature, 402
D. Danilenko, B. Ring, G. Pierce (1996)
Growth factors and cytokines in hair follicle development and cycling: recent insights from animal models and the potentials for clinical therapy.Molecular medicine today, 2 11
A. Limat, T. Hunziker, E. Waelti, S. Inaebnit, U. Wiesmann, L. Braathen (2004)
Soluble factors from human hair papilla cells and dermal fibroblasts dramatically increase the clonal growth of outer root sheath cellsArchives of Dermatological Research, 285
C. Heldin, B. Westermark (1999)
Mechanism of action and in vivo role of platelet-derived growth factor.Physiological reviews, 79 4
Abstract: Platelet‐derived growth factor (PDGF) is a potent mitogenic factor for many cell types and has been shown to be important in follicular development and vasculogenesis. In this study, we examined the expression pattern of both PDGF factors and their corresponding receptors in mesenchyme‐derived dermal papilla cells (DPCs) and epithelial follicular keratinocytes (FKs). Both types of PDGF receptors are expressed in FKs, whereas DPCs only express PDGF receptor β on the protein level, a finding also seen in whole organ cultures. By examining the expression of PDGF ligands, we were able to show that cultured FKs synthesize both PDGF‐A and PDGF‐B, whereas, DPCs only express PDGF‐A. As immunomodulatory cytokines were shown to affect hair growth, we investigated the effects of IL‐1β, IL‐4, TNF‐α, TGF‐β and IFN‐γ on the expression levels of PDGF factors in cultured DPCs and FKs. Interestingly, we could show a significant down‐regulatory effect by catagen‐inducing cytokines like IL‐1β or IFN‐γ, suggesting a possible involvement of PDGF signaling in the induction of catagen. The question concerning the latter hypothesis remains to be elucidated in further studies on whole organ cultures.
Experimental Dermatology – Wiley
Published: Oct 1, 2003
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