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Electrospun nanofibrous structure: A novel scaffold for tissue engineering

Electrospun nanofibrous structure: A novel scaffold for tissue engineering The architecture of an engineered tissue substitute plays an important role in modulating tissue growth. A novel poly(D,L‐lactide‐co‐glycolide) (PLGA) structure with a unique architecture produced by an electrospinning process has been developed for tissue‐engineering applications. Electrospinning is a process whereby ultra‐fine fibers are formed in a high‐voltage electrostatic field. The electrospun structure, composed of PLGA fibers ranging from 500 to 800 nm in diameter, features a morphologic similarity to the extracellular matrix (ECM) of natural tissue, which is characterized by a wide range of pore diameter distribution, high porosity, and effective mechanical properties. Such a structure meets the essential design criteria of an ideal engineered scaffold. The favorable cell–matrix interaction within the cellular construct supports the active biocompatibility of the structure. The electrospun nanofibrous structure is capable of supporting cell attachment and proliferation. Cells seeded on this structure tend to maintain phenotypic shape and guided growth according to nanofiber orientation. This novel biodegradable scaffold has potential applications for tissue engineering based upon its unique architecture, which acts to support and guide cell growth. © 2002 Wiley Periodicals, Inc. J Biomed Mater Res 60: 613–621, 2002 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Biomedical Materials Research Part A Wiley

Electrospun nanofibrous structure: A novel scaffold for tissue engineering

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References (52)

Publisher
Wiley
Copyright
Copyright © 2002 Wiley Subscription Services, Inc., A Wiley Company
ISSN
1549-3296
eISSN
1552-4965
DOI
10.1002/jbm.10167
Publisher site
See Article on Publisher Site

Abstract

The architecture of an engineered tissue substitute plays an important role in modulating tissue growth. A novel poly(D,L‐lactide‐co‐glycolide) (PLGA) structure with a unique architecture produced by an electrospinning process has been developed for tissue‐engineering applications. Electrospinning is a process whereby ultra‐fine fibers are formed in a high‐voltage electrostatic field. The electrospun structure, composed of PLGA fibers ranging from 500 to 800 nm in diameter, features a morphologic similarity to the extracellular matrix (ECM) of natural tissue, which is characterized by a wide range of pore diameter distribution, high porosity, and effective mechanical properties. Such a structure meets the essential design criteria of an ideal engineered scaffold. The favorable cell–matrix interaction within the cellular construct supports the active biocompatibility of the structure. The electrospun nanofibrous structure is capable of supporting cell attachment and proliferation. Cells seeded on this structure tend to maintain phenotypic shape and guided growth according to nanofiber orientation. This novel biodegradable scaffold has potential applications for tissue engineering based upon its unique architecture, which acts to support and guide cell growth. © 2002 Wiley Periodicals, Inc. J Biomed Mater Res 60: 613–621, 2002

Journal

Journal of Biomedical Materials Research Part AWiley

Published: Mar 15, 2003

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