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The bacterial spore has become attractive to bioc hemists as an object for the study of cellular differentiation and morphogenesis. Vegetative cells are converted to spores in a relatively synchronous fashion through an intricate 1967. The authors thank Dr. Roy Doi and Dr. W. G. Murrell for providing manuscripts The survey of selected literature pertaining to this review was completed in October prior to th eir publ ication. Research cited in this review which originated in the authors' laboratory was supported in part by the United States Public Health Service and the National Science Foundation. One of us (M.P.D.) is a postdoctoral fellow of the American Cancer Society. KORNBERG ET AL. temporal sequence of spatially organized steps. The dormant spores, resistant to extremes of te:naperature, pH, radiation, and enzyme action, germinate within a few minutes in response to specific chemical agents and then grow into vegetative cells. Since these processes take place in bacteria, they are susceptible to analysis by genetic and biochemical techniques which cannot be applied readily to differentiating cells and tissues of higher organisms. This brief review is directed to biochemists in order to acquaint them with what is known ot the chemical makeup of
Annual Review of Biochemistry – Annual Reviews
Published: Jul 1, 1968
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