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Toward an understanding of the role of glutamate in experimental parkinsonism: Agonist‐sensitive sites in the basal ganglia

Toward an understanding of the role of glutamate in experimental parkinsonism: Agonist‐sensitive... Increased glutamatergic transmission in the basal ganglia is implicated in the pathophysiology of Parkinson's disease. However, the mechanisms by which activation of glutamate receptors produce parkinsonism are unknown. Therefore, we examined whether the glutamate agonists N‐methyl‐D‐asparate (NMDA), α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionate (AMPA), kainate, and trans‐(±)‐1‐amino‐1,3‐cyclopentanedicarboxylate produce parkinsonism in rats after microapplication into different subregions of the basal ganglia. Electromyographic activity was used as a measure of parkinsonian rigidity. We found that in the rostral striatum, excitation mediated by NMDA but not by non‐NMDA receptors led to parkinsonism. In the substantia nigra pars reticulata, internal pallidal segment/entopeduncular nucleus, and subthalamic nucleus, activation of AMPA/kainate and metabotropic receptors but not of NMDA receptors led to parkinsonian rigidity. Rigidity occurred also in animals bearing ibotenate‐induced lesions of the posterior part of the striatum and of the external pallidal segment, but not in animals with lesions of the anterior striatum, subthalamic nucleus, internal pallidal segment/entopeduncular nucleus, or substantia nigra pars reticulata. These observations suggest that the activation of glutamate receptor subtypes in the basal ganglia may be differentially involved in the expression of parkinsonian symptoms. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annals of Neurology Wiley

Toward an understanding of the role of glutamate in experimental parkinsonism: Agonist‐sensitive sites in the basal ganglia

Klockgether, Thomas; Turski, Lechoslaw
Annals of Neurology , Volume 34 (4) – Oct 1, 1993
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References (39)

Publisher
Wiley
Copyright
Copyright © 1993 American Neurological Association
ISSN
0364-5134
eISSN
1531-8249
DOI
10.1002/ana.410340413
pmid
7692810
Publisher site
See Article on Publisher Site

Abstract

Increased glutamatergic transmission in the basal ganglia is implicated in the pathophysiology of Parkinson's disease. However, the mechanisms by which activation of glutamate receptors produce parkinsonism are unknown. Therefore, we examined whether the glutamate agonists N‐methyl‐D‐asparate (NMDA), α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionate (AMPA), kainate, and trans‐(±)‐1‐amino‐1,3‐cyclopentanedicarboxylate produce parkinsonism in rats after microapplication into different subregions of the basal ganglia. Electromyographic activity was used as a measure of parkinsonian rigidity. We found that in the rostral striatum, excitation mediated by NMDA but not by non‐NMDA receptors led to parkinsonism. In the substantia nigra pars reticulata, internal pallidal segment/entopeduncular nucleus, and subthalamic nucleus, activation of AMPA/kainate and metabotropic receptors but not of NMDA receptors led to parkinsonian rigidity. Rigidity occurred also in animals bearing ibotenate‐induced lesions of the posterior part of the striatum and of the external pallidal segment, but not in animals with lesions of the anterior striatum, subthalamic nucleus, internal pallidal segment/entopeduncular nucleus, or substantia nigra pars reticulata. These observations suggest that the activation of glutamate receptor subtypes in the basal ganglia may be differentially involved in the expression of parkinsonian symptoms.

Journal

Annals of Neurology – Wiley

Published: Oct 1, 1993

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