Access the full text.
Sign up today, get DeepDyve free for 14 days.
H. Harris, M. Ramsay, N. Andrews, K. Eldridge (2002)
Clinical course of hepatitis C virus during the first decade of infection: cohort studyBMJ : British Medical Journal, 324
(2001)
Peginterferon alpha - 2 b plus ribavirin compared with interferon alpha - 2 b plus ribavirin for initial treatment of chronic hepatitis C : a randomized trial
C. François, I. Bernard, S. Castelain, B. Charleston, M. Fray, J. Capiod, G. Duverlie (2005)
Quantification of Different Human Alpha Interferon Subtypes and Pegylated Interferon Activities by Measuring MxA Promoter ActivationAntimicrobial Agents and Chemotherapy, 49
O. Haller, G. Kochs (2002)
Interferon‐Induced Mx Proteins: Dynamin‐Like GTPases with Antiviral ActivityTraffic, 3
(2007)
Serum alpha - fetoprotein ( AFP ) level predicts treatment outcome in chronic hepatitis C
M. McNiven, H. Cao, K. Pitts, Yisang Yoon (2000)
The dynamin family of mechanoenzymes: pinching in new places.Trends in biochemical sciences, 25 3
(2004)
Anti - genic relevance of F protein in chronic HCV infection
(1994)
Strong transient expression of the type 1interferon –induced Mx A protein in hepatitis A but not in acute hepatitis
M. Reichelt, S. Stertz, J. Krijnse-Locker, O. Haller, G. Kochs (2004)
Missorting of LaCrosse Virus Nucleocapsid Protein by the Interferon‐Induced MxA GTPase Involves Smooth ER MembranesTraffic, 5
S. Kamal, A. Tawil, T. Nakano, Q. He, J. Rasenack, S. Hakam, W. Saleh, A. Ismail, Abdul Aziz, M. Madwar (2005)
Peginterferon α-2b and ribavirin therapy in chronic hepatitis C genotype 4: impact of treatment duration and viral kinetics on sustained virological responseGut, 54
D. Holzinger, C. Jorns, S. Stertz, S. Boisson-Dupuis, R. Thimme, M. Weidmann, J. Casanova, O. Haller, G. Kochs (2007)
Induction of MxA Gene Expression by Influenza A Virus Requires Type I or Type III Interferon SignalingJournal of Virology, 81
E. Mundt (2007)
Human MxA protein confers resistance to double-stranded RNA viruses of two virus families.The Journal of general virology, 88 Pt 4
C. Schindler, Jr Darnell (1995)
Transcriptional responses to polypeptide ligands: the JAK-STAT pathway.Annual review of biochemistry, 64
O. Haller, M. Frese, G. Kochs (1998)
Mx proteins: mediators of innate resistance to RNA viruses.Revue scientifique et technique, 17 1
(2000)
Pegylated interferon alpha - 2 a in patients with chronic hepatitis C and cirrhosis
(2005)
Quantification of different human MxA subtypes and pegylated activation
S. Males, R. Gad, G. Esmat, Hasan Abobakr, M. Anwar, C. Rekacewicz, Mostafa Hoseiny, K. Zalata, M. Abdel-hamid, P. Bedossa, S. Pol, M. Mohamed, A. Fontanet (2007)
Serum alpha-foetoprotein level predicts treatment outcome in chronic hepatitis C.Antiviral therapy, 12 5
(2000)
Analysis of successful immune responses in persons infected with HCV
G. Giannelli, Graziana Guadagnino, P. Dentico, G. Antonelli, S. Antonaci (2004)
MxA and PKR expression in chronic hepatitis C.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, 24 11
F. Komurian-Pradel, A. Rajoharison, J. Berland, Valérie Khouri, M. Perret, M. Roosmalen, S. Pol, F. Negro, G. Paranhos-Baccalà (2004)
Antigenic relevance of F protein in chronic hepatitis C virus infectionHepatology, 40
K. Batts, J. Ludwig (1995)
Chronic hepatitis. An update on terminology and reporting.The American journal of surgical pathology, 19 12
F. Lechner, D. Wong, P. Dunbar, R. Chapman, R. Chung, P. Dohrenwend, G. Robbins, R. Phillips, P. Klenerman, B. Walker (2000)
Analysis of Successful Immune Responses in Persons Infected with Hepatitis C VirusThe Journal of Experimental Medicine, 191
M. Frese, T. Pietschmann, D. Moradpour, O. Haller, R. Bartenschlager (2001)
Interferon-α inhibits hepatitis C virus subgenomic RNA replication by an MxA-independent pathwayJournal of General Virology, 82
C. Frank, M. Mohamed, G. Strickland, D. Lavanchy, R. Arthur, L. Magder, Taha Khoby, Yehia Abdel-Wahab, El Ohn, W. Anwar, I. Sallam (2000)
The role of parenteral antischistosomal therapy in the spread of hepatitis C virus in EgyptThe Lancet, 355
A. Roers, H. Hochkeppel, M. Horisberger, A. Hovanessian, Otto Haller (1994)
MxA gene expression after live virus vaccination: a sensitive marker for endogenous type I interferon.The Journal of infectious diseases, 169 4
(2007)
Serum alpha-fetoprotein (AFP) level predicts treatment outcome in chronic hepatitis
(2007)
Hepatitis C virus expression and interferon antiviral action is dependant on PKR expression
Yoshio Tokumoto, Y. Hiasa, N. Horiike, K. Michitaka, B. Matsuura, R. Chung, M. Onji (2007)
Hepatitis C virus expression and interferon antiviral action is dependent on PKR expressionJournal of Medical Virology, 79
M. Fernandez, J. Quiroga, J. Martin, M. Herrero, M. Pardo, M. Horisberger, V. Carreño (1999)
In vivo and in vitro induction of MxA protein in peripheral blood mononuclear cells from patients chronically infected with hepatitis C virus.The Journal of infectious diseases, 180 2
A. Bisceglie, J. Hoofnagle (2002)
Optimal therapy of hepatitis CHepatology, 36
E. Heathcote, Mitchell Shiffman, W. Cooksley, Geoffrey Dusheiko, Samuel Lee, Luis Balart, R. Reindollar, rajender. reddy, Teresa Wright, A. Lin, J. Hoffman, J. Pamphilis (2000)
Peginterferon alfa-2a in patients with chronic hepatitis C and cirrhosis.The New England journal of medicine, 343 23
L. Seeff (2002)
Natural history of chronic hepatitis CHepatology, 36
S. Mihm, M. Frese, V. Meier, P. Wietzke-Braun, J. Scharf, R. Bartenschlager, G. Ramadori (2004)
Interferon type I gene expression in chronic hepatitis CLaboratory Investigation, 84
G. MacQuillan, C. Mamotte, W. Reed, G. Jeffrey, J. Allan (2003)
Upregulation of endogenous intrahepatic interferon stimulated genes during chronic hepatitis C virus infectionJournal of Medical Virology, 70
D. Jakschies, R. Zachoval, R. Müller, M. Manns, K. Nolte, H. Hochkeppel, M. Horisberger, H. Deicher, P. Wussow (1994)
Strong transient expression of the type I interferon–induced MxA protein in hepatitis A but not in acute hepatitis B and CHepatology, 19
For Personal Use. Only Reproduce with Permission from the Lancet Publishing Group
(2002)
Clinical course of HCV during the first decade of infection : cohort study
Yasuhiro Itsui, N. Sakamoto, M. Kurosaki, N. Kanazawa, Y. Tanabe, Tomoyuki Koyama, Y. Takeda, M. Nakagawa, S. Kakinuma, Y. Sekine, S. Maekawa, N. Enomoto, M. Watanabe (2006)
Expressional screening of interferon‐stimulated genes for antiviral activity against hepatitis C virus replicationJournal of Viral Hepatitis, 13
Summary. The prevalence of hepatitis C virus (HCV) infection varies across the world, with the highest number of infections reported in Egypt. Expression of the MxA gene has been found to be a reliable and sensitive marker for the induction of endogenous type I interferons (IFNs) during viral infections. This study examined the correlation of gene expression of MxA with the response to treatment with pegylated‐IFN‐alfa2b and ribavirin. Fifty patients with type 4 HCV and 20 healthy volunteers as controls were enrolled in a prospective study designed with strict inclusion criteria to nullify the effect of confounding variables and further minimize selection bias. Quantification of HCV‐RNA and MxA gene by real‐time PCR was performed for every patient, and quantification of MxA gene was performed for controls. There was a statistically significant difference between patients and control group as regards the quantity of MxA gene expression (P < 0.05) (Mann–Whitney test) (P = 0.004). There was a statistically significant difference between responders and nonresponders (P < 0.05): responders showed a higher percentage of cases with initial MxA <26 (P < 0.05). We conclude that MxA protein expression is a sensitive biological marker for ongoing virus replication and presence of type 1 IFN. These results highlight the importance of the detection of MxA expression at the start of therapy as a factor for assessing the likelihood of HCV genotype 4 patients to achieving a sustained virological response to treatment with IFN‐α2 in combination with ribavirin.
Journal of Viral Hepatitis – Wiley
Published: Nov 1, 2010
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.