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Pathogenic mechanisms in the rheumatoid nodule: Comparison of proinflammatory cytokine production and cell adhesion molecule expression in rheumatoid nodules and synovial membranes from the same patient

Pathogenic mechanisms in the rheumatoid nodule: Comparison of proinflammatory cytokine production... Objective To investigate the production of proinflammatory cytokines and expression of cell adhesion molecules in the rheumatoid nodule. Methods Cytokine content (tumor necrosis factor α (TNFα), interleukin‐1β (IL‐1β), and IL‐1 receptor antagonist (IL‐1Ra)), at the messenger RNA (mRNA) and protein levels, and cell adhesion molecule expression were studied in 16 rheumatoid nodules and 6 synovial membranes. Results Macrophages in the rheumatoid nodules contained TNFα, IL‐1β, and IL‐1Ra mRNA and protein, particularly in perivascular cells of the stroma and in the palisading layer. All cell adhesion molecules studied were expressed in both the rheumatoid nodules and synovial membranes, with increased expression of E‐selectin in the rheumatoid nodule compared with the synovial membrane, and with the absence of vascular cell adhesion molecule 1 expression on cells of the palisading layer in the rheumatoid nodule. Conclusion The presence of similar proinflammatory cytokines and cell adhesion molecules in the rheumatoid nodule and synovial membrane suggests that similar pathogenic processes result in the chronic inflammation and tissue destruction in these lesions. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Arthritis & Rheumatism Wiley

Pathogenic mechanisms in the rheumatoid nodule: Comparison of proinflammatory cytokine production and cell adhesion molecule expression in rheumatoid nodules and synovial membranes from the same patient

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References (49)

Publisher
Wiley
Copyright
Copyright © 1998 by the American College of Rheumatology
ISSN
0004-3591
eISSN
1529-0131
DOI
10.1002/1529-0131(199810)41:10<1783::AID-ART10>3.0.CO;2-W
pmid
9778219
Publisher site
See Article on Publisher Site

Abstract

Objective To investigate the production of proinflammatory cytokines and expression of cell adhesion molecules in the rheumatoid nodule. Methods Cytokine content (tumor necrosis factor α (TNFα), interleukin‐1β (IL‐1β), and IL‐1 receptor antagonist (IL‐1Ra)), at the messenger RNA (mRNA) and protein levels, and cell adhesion molecule expression were studied in 16 rheumatoid nodules and 6 synovial membranes. Results Macrophages in the rheumatoid nodules contained TNFα, IL‐1β, and IL‐1Ra mRNA and protein, particularly in perivascular cells of the stroma and in the palisading layer. All cell adhesion molecules studied were expressed in both the rheumatoid nodules and synovial membranes, with increased expression of E‐selectin in the rheumatoid nodule compared with the synovial membrane, and with the absence of vascular cell adhesion molecule 1 expression on cells of the palisading layer in the rheumatoid nodule. Conclusion The presence of similar proinflammatory cytokines and cell adhesion molecules in the rheumatoid nodule and synovial membrane suggests that similar pathogenic processes result in the chronic inflammation and tissue destruction in these lesions.

Journal

Arthritis & Rheumatism – Wiley

Published: Oct 1, 1998

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