Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Design and Analysis of Case-Control Studies

Design and Analysis of Case-Control Studies A primary goal of epidemiological research is to describe how the exposure of members of a population to certain risk factors influences quent disease incidence. Such a description is relatively straightforward for cohort studies, where exposed and unexposed members of the study group are followed forward in time so as to permit direct measurement of the relevant disease rates. Cohort studies of rare diseases are extremely costly and time consuming, however, since large groups must be assembled and followed up many years in order to collect enough cases for meaningful statistical analysis. The case-control study, wherein one compares cases and disease-free controls vis-a-vis exposure histories obtained by interview or other retrospective means, has been gaining favor in recent years as a valid and cost-effective alternative method (1). Case-control studies have contributed to the solution of important public health problems. This is exemplified ing endometrial cancer were more likely than controls to have received treatment with exogenous estrogens for menopausal symptoms (2, 3). How­ ever, the fierce debate that followed publication of these findings reminds us that such studies must be designed carefully in order to provide a true picture of the effect of exposure on incidence. Major issues http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Public Health Annual Reviews

Design and Analysis of Case-Control Studies

Breslow, N
Annual Review of Public Health , Volume 3 (1) – May 1, 1982
Download PDF
26 pages

Loading next page...
 
/lp/annual-reviews/design-and-analysis-of-case-control-studies-GVFV09Vg3z

References

References for this paper are not available at this time. We will be adding them shortly, thank you for your patience.

Publisher
Annual Reviews
Copyright
Copyright 1982 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0163-7525
eISSN
1545-2093
DOI
10.1146/annurev.pu.03.050182.000333
pmid
6756431
Publisher site
See Article on Publisher Site

Abstract

A primary goal of epidemiological research is to describe how the exposure of members of a population to certain risk factors influences quent disease incidence. Such a description is relatively straightforward for cohort studies, where exposed and unexposed members of the study group are followed forward in time so as to permit direct measurement of the relevant disease rates. Cohort studies of rare diseases are extremely costly and time consuming, however, since large groups must be assembled and followed up many years in order to collect enough cases for meaningful statistical analysis. The case-control study, wherein one compares cases and disease-free controls vis-a-vis exposure histories obtained by interview or other retrospective means, has been gaining favor in recent years as a valid and cost-effective alternative method (1). Case-control studies have contributed to the solution of important public health problems. This is exemplified ing endometrial cancer were more likely than controls to have received treatment with exogenous estrogens for menopausal symptoms (2, 3). How­ ever, the fierce debate that followed publication of these findings reminds us that such studies must be designed carefully in order to provide a true picture of the effect of exposure on incidence. Major issues

Journal

Annual Review of Public Health – Annual Reviews

Published: May 1, 1982

There are no references for this article.