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F. Gilbert, C. Dourish (2004)
Effects of the novel anxiolytics gepirone, buspirone and ipsapirone on free feeding and on feeding induced by 8-OH-DPATPsychopharmacology, 93
S. File, P. Mabbutt, JACQUELINE Walker (1988)
Comparison of Adaptive Responses in Familiar and Novel Environments: Modulatory FactorsAnnals of the New York Academy of Sciences, 525
D. Blanchard, R. Blanchard, R. Rodgers (1990)
Pharmacological and neural control of anti-predator defense in the ratAggressive Behavior, 16
R. Blanchard, D. Blanchard (1989)
Antipredator defensive behaviors in a visible burrow system.Journal of comparative psychology, 103 1
D. Blanchard, R. Blanchard, Paul Tom, R. Rodgers (2005)
Diazepam changes risk assessment in an anxiety/defense test batteryPsychopharmacology, 101
G. Higgins, A. Bradbury, B. Jones, N. Oakley (1988)
Behavioural and biochemical consequences following activation of 5HT1-like and GABA receptors in the dorsal raphé nucleus of the ratNeuropharmacology, 27
R. Shephard (1986)
Neurotransmitters, anxiety and benzodiazepines: A behavioral reviewNeuroscience & Biobehavioral Reviews, 10
A. Johnston, S. File (1986)
5-HT and anxiety: Promises and pitfallsPharmacology Biochemistry and Behavior, 24
R. Blanchard, D. Blanchard, S. Weiss (1990)
Ethanol effects in an anxiety/defense test battery.Alcohol, 7 5
M. Critchley, S. Handley (2004)
Effects in the X-maze anxiety model of agents acting at 5-HT1 and 5-HT2 receptorsPsychopharmacology, 93
Paul Moser, M. Tricklebank, D. Middlemiss, Anis Mir, Marcel Hibert, J. Fozard (1990)
Characterization of MDL 73005EF as a 5‐HT1A selective ligand and its effects in animal models of anxiety: comparison with buspirone, 8‐OH‐DPAT and diazepamBritish Journal of Pharmacology, 99
Witkin Jm, Pérez La (1990)
Comparison of effects of buspirone and gepirone with benzodiazepines and antagonists of dopamine and serotonin receptors on punished behavior of rats.Behavioural Pharmacology, 1
R. Blanchard, D. Blanchard, S. Weiss, Scott Meyer (1990)
The effects of ethanol and diazepam on reactions to predatory odorsPharmacology Biochemistry and Behavior, 35
J. Engel, S. Hjorth, K. Svensson, A. Carlsson, S. Liljequist (1984)
Anticonflict effect of the putative serotonin receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT).European journal of pharmacology, 105 3-4
M. Carli, R. Samanin (2004)
Potential anxiolytic properties of 8-hydroxy-2-(Di-N-propylamino)tetralin, a selective serotonin1A receptor agonistPsychopharmacology, 94
C. Dourish, P. Hutson, G. Kennett, G. Curzon (1986)
8-OH-DPAT-induced hyperphagia: Its neural basis and possible therapeutic relevanceAppetite, 7
R. Rodgers, J. Shepherd (2004)
Prevention of the analgesic consequences of social defeat in male mice by 5-HT1A anxiolytics, buspirone, gepirone and ipsapironePsychopharmacology, 99
R. Rodgers, A. Waters (1985)
Benzodiazepines and their antagonists: A pharmacoethological analysis with particular reference to effects on “aggression”Neuroscience & Biobehavioral Reviews, 9
R. Dunn, R. Corbett, S. Fielding (1989)
Effects of 5-HT1A receptor agonists and NMDA receptor antagonists in the social interaction test and the elevated plus maze.European journal of pharmacology, 169 1
D. Wong, L. Reid (1987)
Fenfluramine antagonizes the stimulation of food intake induced by the putative 5‐hydroxytryptamine1A agonist, isapirone, in non‐fasted ratsJournal of Pharmacy and Pharmacology, 39
J. Traber, T. Glaser (1987)
5-HT1A receptor-related anxiolyticsTrends in Pharmacological Sciences, 8
S. Pellow, A. Johnston, S. File (1987)
Selective agonists and antagonists for 5‐hydroxytryptamine receptor subtypes, and interactions with yohimbine and FG 7142 using the elevated plus‐maze test in the ratJournal of Pharmacy and Pharmacology, 39
S. Iversen (1984)
5-HT and anxietyNeuropharmacology, 23
J. Evenden, K. Ängeby-Möller (2005)
Effects of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) on locomotor activity and rearing of mice and ratsPsychopharmacology, 102
T. Meert, P. Janssen (1989)
Psychopharmacology of ritanserin: Comparison with chlordiazepoxideDrug Development Research, 18
D. Blanchard, R. Rodgers, C. Hendrie, K. Hori (1988)
‘Taming’ of wild rats (Rattus rattus) by 5HT1A agonists buspirone and gepironePharmacology Biochemistry and Behavior, 31
H. Hodges, Simon Green, B. Glenn (2004)
Evidence that the amygdala is involved in benzodiazepine and serotonergic effects on punished responding but not on discriminationPsychopharmacology, 92
J. Neill, S. Cooper (1988)
MDL 72832, a selective 5-HT1A receptor ligand, stereospecifically increases food intake.European journal of pharmacology, 151 2
R. Mansbach, Mark Geyer (1988)
Blockade of potentiated startle responding in rats by 5-hydroxytryptamine1A receptor ligands.European journal of pharmacology, 156 3
D. Haleem, G. Kennett, G. Curzon (2005)
Hippocampal 5-hydroxytryptamine synthesis is greater in female rats than in males and more decreased by the 5-HT1A agonist 8-OH-DPATJournal of Neural Transmission / General Section JNT, 79
B. Richardson, D. Hoyer (1990)
Selective Agonists and Antagonists at 5-Hydroxytryptamine Receptor Subtypes
R. Rodgers, D. Blanchard, L. Wong, R. Blanchard (1990)
Effects of scopolamine on antipredator defense reactions in wild and laboratory ratsPharmacology Biochemistry and Behavior, 36
R. Rodgers, J. Shepherd (2004)
5HT1A agonist, 8-hydroxy-2-(DI-n-propylamino)tetralin (8-OH-DPAT), inhibits non-opioid analgesia in defeated mice: influence of route of administrationPsychopharmacology, 97
G. Gudelsky, James Koenig, Herbert Meltzer (1986)
Thermoregulatory responses to serotonin (5-HT) receptor stimulation in the rat Evidence for opposing roles of 5-HT2 and 5-HT1A receptorsNeuropharmacology, 25
Michael Davis, J. Cassella, J. Kehne (2004)
Serotonin does not mediate anxiolytic effects of buspirone in the fear-potentiated startle paradigm: comparison with 8-OH-DPAT and ipsapironePsychopharmacology, 94
213 106 106 4 4 D. Caroline Blanchard Jon K. Shepherd R. J. Rodgers Robert J. Blanchard Bekesy Laboratory of Neurobiology, John A. Burns School of Medicine University of Hawaii 1993 East-West Road 96822 Honolulu HI USA Department of Anatomy and Reproductive Biology, John A. Burns School of Medicine University of Hawaii 1993 East-West Road 96822 Honolulu HI USA Department of Psychology University of Hawaii 1993 East-West Road 96822 Honolulu HI USA Department of Psychology University of Leeds LS2 9JT Leeds UK Abstract The Proxemics/Activity test and the Eat/Drink test, two components of the Anxiety/Defense Test Battery, were developed to measure defensive reactions to situations associated with a natural predator (cat). In the present studies the behavioral effects of 8-OH-DPAT treatment (0.01–1.0 mg/kg, SC) were entirely consistent with anxiety/fear reduction. These effects included an increase in time spent near the cat compartment, and a complimentary decrease in time spent farthest from this compartment, together with an increase in transits and locomote behavior. 8-OH-DPAT (1.0 mg/kg) also increased eat frequencies and durations (highly preferred food) both during and following cat presentation, without influencing drinking. This finding is discussed with reference to previous findings with 8-OH-DPAT in studies assessing both food intake and anxiolysis. Interestingly, 8-OH-DPAT was more potent in a majority of its effects in female subjects, a finding consistent with recent neurochemical data. These findings provide important behavioral evidence for a sexual differentiation in 5-HT function, and support the case for greater emphasis on female subjects in animal models of anxiety.
Psychopharmacology – Springer Journals
Published: Apr 1, 1992
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