Access the full text.
Sign up today, get DeepDyve free for 14 days.
R. Stout (1982)
Is insulin atherogenic?The Mount Sinai journal of medicine, New York, 49 3
T. Welborn, K. Wearne (1979)
Coronary Heart Disease Incidence and Cardiovascular Mortality in Busselton with Reference to Glucose and Insulin ConcentrationsDiabetes Care, 2
(1981)
Les cardiopathies isch6miques: incidence et facteurs de risque. L'Etude Prospective Parisienne
D. Cox (1972)
Regression models and life tables (with discussion
M. Gough, J. Bell (1989)
Introducing aptitude testing into medicine.British Medical Journal, 298
S. Haffner, M. Stern, B. Mitchell, H. Hazuda, J. Patterson (1990)
Incidence of Type II Diabetes in Mexican Americans Predicted by Fasting Insulin and Glucose Levels, Obesity, and Body-Fat DistributionDiabetes, 39
(1973)
Quelques informations sur la frdquence en France des maladies cardi 0 vasculaires , particuli 6 rement des cardiopathies isch 4 miques
D. Betteridge (1989)
High density lipoprotein and coronary heart disease.British Medical Journal, 298
R. Jarrett, M. Shipley (1988)
Type 2 (non-insulin-dependent) diabetes mellitus and cardiovascular disease — putative association via common antecedents; further evidence from the whitehall studyDiabetologia, 31
P. Ducimetiere, E. Eschwège, L. Papoz, J. Richard, J. Claude, G. Rosselin (1980)
Relationship of plasma insulin levels to the incidence of myocardial infarction and coronary heart disease mortality in a middle-aged populationDiabetologia, 19
G. Reaven (1988)
Role of Insulin Resistance in Human DiseaseDiabetes, 37
P. Fossati, M. Romon-Rousseaux (1987)
Insulin and HDL-cholesterol metabolism.Diabete & metabolisme, 13 3 Pt 2
G. Rosselin, R. Assan, R. Yalow, S. Berson (1966)
Separation of Antibody-Bound and Unbound Peptide Hormones Labelled with Iodine-131 by Talcum Powder and Precipitated SilicaNature, 212
E. Muscelli, M. Saad, J. Gontijo (1990)
Insulin resistance in essential hypertension.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 23 12
M. Stalder, D. Pometta, A. Suenram (1981)
Relationship between plasma insulin levels and high density lipoprotein cholesterol levels in healthy menDiabetologia, 21
E. Eschwège, Richards Jl, N. Thibult, P. Ducimetiere, J. Warnet, Claude, Rosselin Ge (1985)
Coronary heart disease mortality in relation with diabetes, blood glucose and plasma insulin levels. The Paris Prospective Study, ten years later.Hormone and metabolic research. Supplement series, 15
(1988)
Risk factors of Type 2 (non-insulin-dependent) diabetes in a Caucasian population
R. Temple, S. Luzio, A. Schneider, C. Carrington, D. Owens, W. Sobey, C. Hales (1989)
INSULIN DEFICIENCY IN NON-INSULIN-DEPENDENT DIABETESThe Lancet, 333
L. Ho, Z. Chang, J.T. Wang, S.H. Li, Y.F. Liu, Ydi Chen, G. Reaven (1990)
Insulin Insensitivity in Offspring of Parents with Type 2 Diabetes MellitusDiabetic Medicine, 7
K. Pyörälä, M. Uusitupa, M. Laakso, O. Siitonen, L. Niskanen, T. Rönnemaa (1987)
Macrovascular complications in relation to hyperinsulinaemia in non-insulin-dependent diabetes mellitus.Diabete & metabolisme, 13 3 Pt 2
M. Modan, H. Halkin, S. Almog, A. Lusky, A. Eshkol, M. Shefi, A. Shitrit, Z. Fuchs (1985)
Hyperinsulinemia. A link between hypertension obesity and glucose intolerance.The Journal of clinical investigation, 75 3
D. Foster (1989)
Insulin resistance--a secret killer?The New England journal of medicine, 320 11
W. Castelli (1986)
The triglyceride issue: a view from Framingham.American heart journal, 112 2
A. Fontbonne, E. Eschwège, F. Cambien, J. Richard, P. Ducimetiere, N. Thibult, J. Warnet, J. Claude, G. Rosselin (1989)
Hypertriglyceridaemia as a risk factor of coronary heart disease mortality in subjects with impaired glucose tolerance or diabetesDiabetologia, 32
R. Leslie, H. Volkmann, M. Poncher, I. Hanning, H. Orskov, K. Alberti (1986)
Metabolic abnormalities in children of non-insulin dependent diabetics.British Medical Journal (Clinical research ed.), 293
C. Young, R. Karas, J. Kuvin (2004)
High-Density Lipoprotein Cholesterol and Coronary Heart DiseaseCardiology in Review, 12
W. Castelli, R. Garrison, P. Wilson, R. Abbott, S. Kalousdian, W. Kannel (1986)
Incidence of coronary heart disease and lipoprotein cholesterol levels. The Framingham Study.JAMA, 256 20
K. Pyörälä, E. Savolainen, S. Kaukola, J. Haapakoski (2009)
Plasma insulin as coronary heart disease risk factor: relationship to other risk factors and predictive value during 9 1/2-year follow-up of the Helsinki Policemen Study population.Acta medica Scandinavica. Supplementum, 701
C. Bogardus, S. Lillioja, B. Howard, G. Reaven, D. Mott (1984)
Relationships between insulin secretion, insulin action, and fasting plasma glucose concentration in nondiabetic and noninsulin-dependent diabetic subjects.The Journal of clinical investigation, 74 4
R. Stout (1990)
Insulin and atheroma. 20-yr perspective.Diabetes care, 13 6
I. Zavaroni, E. Bonora, Massimo Pagliara, E. Dall’aglio, L. Luchetti, Giuseppe Buonanno, Piero Bonati, Marcello Bergonzani, L. Gnudi, M. Passeri, G. Reaven (1989)
Risk factors for coronary artery disease in healthy persons with hyperinsulinemia and normal glucose tolerance.The New England journal of medicine, 320 11
R. Sicree, P. Zimmet, H. King, J. Coventry (1987)
Plasma Insulin Response Among Nauruans: Prediction of Deterioration in Glucose Tolerance Over 6 YrDiabetes, 36
R. Stout, J. Vallance‐owen (1969)
Insulin and atheroma.Lancet, 1 7605
D. Nagi, T. Hendra, A. Ryle, T. Cooper, R. Temple, P. Clark, A. Schneider, C. Hales, J. Yudkin (1990)
The relationships of concentrations of insulin, intact proinsulin and 32–33 split proinsulin with cardiovascular risk factors in Type 2 (non-insulin-dependent) diabetic subjectsDiabetologia, 33
S. Haffner, M. Stern, H. Hazuda, B. Mitchell, J. Patterson (1988)
Increased insulin concentrations in nondiabetic offspring of diabetic parents.The New England journal of medicine, 320 19
M. Laakso, K. Pyörälä, E. Voutilainen, J. Marniemi (1987)
Plasma insulin and serum lipids and lipoproteins in middle-aged non-insulin-dependent diabetic and non-diabetic subjects.American journal of epidemiology, 125 4
Mohammed Saad, W. Knowler, DavidJ. Pettitt, Robert Nelson, David Mott, Peter Bennett (1988)
The natural history of impaired glucose tolerance in the Pima Indians.The New England journal of medicine, 319 23
K. Pyöräla (1979)
Relationship of glucose tolerance and plasma insulin to the incidence of coronary heart disease: results from two population studies in Finland.Diabetes care, 2 2
T. Tobey, M. Greenfield, F. Kraemer, G. Reaven (1981)
Relationship between insulin resistance, insulin secretion, very low density lipoprotein kinetics, and plasma triglyceride levels in normotriglyceridemic man.Metabolism: clinical and experimental, 30 2
M. Austin (1989)
Plasma triglyceride as a risk factor for coronary heart disease. The epidemiologic evidence and beyond.American journal of epidemiology, 129 2
E. Nikkilä, T. Miettinen, M. Vesenne, R. Pelkonen (1965)
Plasma-insulin in coronary heart-disease: response to oral and intravenous glucose and to tolbutamide.Lancet, 2 7411
Claudia Heller, H. Coirini, A. Nicola (1983)
The Placenta as a Glucocorticoid Target Tissue: Exchange Assay of (3H)-Dexamethasone Binding and Effect of Steroids on Receptor ContentHorm. metabol. Res., 15
A. Hill (1965)
The Environment and Disease: Association or Causation?Journal of the Royal Society of Medicine, 58
A. Barr (1979)
SAS user's guide
125 34 34 5 5 A. Fontbonne M. A. Charles N. Thibult J. L. Richard J. R. Claude J. M. Warnet G. E. Rosselin E. Eschwège INSERM U21 Villejuif France INSERM U258 Paris France Center for Prevention of Cardiovascular Diseases DASES Paris France INSERM U55 Paris France Summary The Paris Prospective Study is a long-term, largescale study of the factors predicting coronary heart disease. The first follow-up examination included, for subjects not known as having diabetes mellitus, a 75 g oral glucose tolerance test with measurement of plasma insulin and glucose levels, fasting and 2 h post-load. Between 1968 and 1973, 6903 men aged 43–54 years were thus examined. Causes of death were ascertained within this group after 15 years of mean follow-up. The baseline variables were tested as predictors of death from coronary heart disease by a Cox regression analysis. Significant independent predictors of coronary heart disease death were: systolic blood pressure, number of cigarettes per day, plasma cholesterol level, and 2 h post-load plasma insulin level when entered as a categorical variable (below or above 452 pmol/l, i.e. the lower limit of the fifth quintile of the distribution). This dichotomization was performed to account for the non-linear univariate distribution of deaths with increasing post-load insulin values. Fasting plasma insulin level was not an independent predictor of death by coronary heart disease over this long-term follow-up. Levels of blood glucose were not significant independent predictors of death by coronary heart disease when plasma insulin levels were included in the model. The same applied to abnormalities of glucose tolerance when the 125 men with known non-insulin-treated diabetes at baseline were added to the group. Under the assumption that hyperinsulinaemia is a marker of insulin resistance, the results are consistent with the hypothesis that insulin resistance is associated with a higher risk of coronary heart disease mortality. However, it is doubtful that circulating insulin per se is a direct cause of arterial complications.
Diabetologia – Springer Journals
Published: May 1, 1991
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.