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References (26)
-
D. Berg (1984)
New neuronal growth factors.Annual review of neuroscience, 7
-
H. Hofmann, K. Unsicker (2005)
The seminal vesicle of the bull: a new and very rich source of nerve growth factor.European journal of biochemistry, 128 2-3
-
K. Suda, Y. Barde, H. Thoenen (1978)
Nerve growth factor in mouse and rat serum: correlation between bioassay and radioimmunoassay determinations.Proceedings of the National Academy of Sciences of the United States of America, 75 8
-
R. Morrison (1987)
Fibroblast growth factors: Potential neurotrophic agents in the central nervous systemJournal of Neuroscience Research, 17
-
F. Hefti, J. Hartikka, F. Eckenstein, H. Gnahn, R. Heumann, M. Schwab (1985)
Nerve growth factor increases choline acetyl-transferase but not survival or fiber outgrowth of cultured fetal septal cholinergic neuronsNeuroscience, 14
-
Y. Barde, D. Edgar, H. Thoenen (1983)
New neurotrophic factors.Annual review of physiology, 45
-
M. Manthorpe, S. Skaper, L. Williams, S. Varon (1986)
Purification of adult rat sciatic nerve ciliary neuronotrophic factorBrain Research, 367
-
B. Westermark (1976)
Density dependent proliferation of human glia cells stimulated by epidermal growth factor.Biochemical and biophysical research communications, 69 2
-
HD Hofmann (1988)
Development of cholinergic retinal neurons from embryonic chicken in monolayer cultures: stimulation by glial cell-derived factors, 8
-
S. Varon, R. Adler (1980)
Nerve growth factors and control of nerve growth.Current topics in developmental biology, 16
-
J. Johnson, Y. Barde, M. Schwab, H. Thoenen (1986)
Brain-derived neurotrophic factor supports the survival of cultured rat retinal ganglion cells, 6
-
F. Hefti (1986)
Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transections, 6
-
Hans Thoenen, C. Bandtlow, R. Heumann (1987)
The physiological function of nerve growth factor in the central nervous system: comparison with the periphery.Reviews of physiology, biochemistry and pharmacology, 109
-
S. Varon, R. Adler (1981)
Trophic and Specifying Factors Directed to Neuronal CellsAdvances in Cell Biology, 2
-
H. Hofmann, K. Unsicker (1987)
Characterization and Partial Purification of a Novel Neuronotrophic Factor from Bovine Seminal VesicleJournal of Neurochemistry, 48
-
S. Varon, M. Manthorpe (1984)
Trophic and Neurite-Promoting Factors for Cholinergic Neurons -
G. Barbin, M. Manthorpe, S. Varon (1984)
Purification of the Chick Eye Ciliary Neuronotrophic FactorJournal of Neurochemistry, 43
-
D. Gospodarowicz (1984)
Biological activity in vivo and in vitro of pituitary and brain fibroblast growth factor.Symposium on Fundamental Cancer Research, 37
-
Y. Barde, D. Edgar, H. Thoenen (1982)
Purification of a new neurotrophic factor from mammalian brain.The EMBO Journal, 1
-
Varon Varon, Adler Adler (1981)
Trophic and specifying factors directed to neuronal cellsAdv. Cell. Neurobiol, 2
-
Honegger Honegger, Lenoir Lenoir (1982)
Nerve growth factor (NGF) stimulation of cholinergic telencephalic neurons in aggregating cell culturesDev. Brain Res, 3
-
F. Fonnum (1975)
A rapid radiochemical method for the determination of choline acetyltransferaseJournal of Neurochemistry, 24
-
P. Honegger, D. Lenoir (1982)
Nerve growth factor (NGF) stimulation of cholinergic telencephalic neurons in aggregating cell cultures.Brain research, 255 2
-
(1985)
Neuronotrophic factors, in Cell Culture in fhe Neurosciences (Bottenstein -
T. Millar, I. Ishimoto, C. Johnson, M. Epstein, I. Chubb, I. Morgan (1985)
Cholinergic and acetylcholinesterase-containing neurons of the chicken retinaNeuroscience Letters, 61
-
(1987)
The physiolog-61
- Publisher
- Wiley
- Copyright
- Copyright © 1988 Wiley Subscription Services, Inc., A Wiley Company
- ISSN
- 0022-3042
- eISSN
- 1471-4159
- DOI
- 10.1111/j.1471-4159.1988.tb04842.x
- Publisher site
- See Article on Publisher Site
Abstract
It has been demonstrated that cultured choliner‐gic retinal neurons from 8‐day‐old chicken embryos respond to a polypeptide factor present in retinal cell‐conditioned medium (RCM) and in retinal extracts. Compared with control cultures, the activity of acetyl‐CoAxholine O‐acetyltransferase (EC 2.3.1.6; ChAT) is enhanced more than twofold in neuronal retinal cultures grown for 7 days in the presence of RCM. The present study demonstrates that both ciliary neuronotrophic factor (CNTF), which is characterized by its trophic activity on parasympathetic ciliary neurons, and RCM exhibit identical stimulatory effects on ChAT activity in retinal monolayer cultures. Similarly, RCM supports the in vitro survival of ciliary neurons to the same extent as CNTF. The active species in RCM has a molecular weight (20,900 ± 1,000) identical to that of CNTF, as determined by preparative sodium dodecyl sul‐fate gel electrophoresis. The results indicate that cholinergic retinal neurons represent a central neuronal target for CNTF or a closely related protein.
Journal
Journal of Neurochemistry – Wiley
Published: Jul 1, 1988