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D. Leifer, S. Lipton, C. Barnstable, R. Masland (1984)
Monoclonal antibody to Thy-1 enhances regeneration of processes by rat retinal ganglion cells in culture.Science, 224 4646
A. Thomson, D. West, D. Lodge (1985)
An N-methylaspartate receptor-mediated synapse in rat cerebral cortex: a site of action of ketamine?Nature, 313
J. Huettner, R. Baughman (1986)
Primary culture of identified neurons from the visual cortex of postnatal rats, 6
C. Jahr, T. Jessell (1985)
Synaptic transmission between dorsal root ganglion and dorsal horn neurons in culture: antagonism of monosynaptic excitatory postsynaptic potentials and glutamate excitation by kynurenate, 5
J. Bolz, H. Wässle, P. Thier (1984)
Pharmacological modulation of on and off ganglion cells in the cat retinaNeuroscience, 12
J. Watkins, R. Evans (1981)
Excitatory amino acid transmitters.Annual review of pharmacology and toxicology, 21
(1985)
Differing effects of glutamate analogs and antagonists in the rabbit retina
Robert Miller, M. Slaughter (1986)
Excitatory amino acid receptors of the retina: diversity of subtypes and conductance mechanismsTrends in Neurosciences, 9
U. Drager, D. Edwards, C. Barnstable (1984)
Antibodies against filamentous components in discrete cell types of the mouse retina, 4
R. O’Brien, G. Fischbach (1986)
Characterization of excitatory amino acid receptors expressed by embryonic chick motoneurons in vitro, 6
A. Ganong, T. Lanthorn, C. Cotman (1983)
Kynurenic acid inhibits synaptic and acidic amino acid-induced responses in the rat hippocampus and spinal cordBrain Research, 273
S. Bloomfield, J. Dowling (1985)
Roles of aspartate and glutamate in synaptic transmission in rabbit retina. II. Inner plexiform layer.Journal of neurophysiology, 53 3
G. Westbrook, M. Mayer (1984)
Glutamate currents in mammalian spinal neurons: resolution of a paradoxBrain Research, 301
A. Ganong, A. Jones, J. Watkins, C. Cotman (1986)
Parallel antagonism of synaptic transmission and kainate/quisqualate responses in the hippocampus by piperazine-2,3-dicarboxylic acid analogs, 6
(1983)
Neurofilaments contain amelanocypte-stimulating hormone (a-MSH)-like immunoreactivity. Proceeding8 of the National Academy of
V. Crunelli, S. Forda, J. Kelly (1984)
The reversal potential of excitatory amino acid action on granule cells of the rat dentate gyrus.The Journal of Physiology, 351
U. Dräger, A. Hofbauer (1984)
Antibodies to heavy neurofilament subunit detect a subpopulation of damaged ganglion cells in retinaNature, 309
(1986)
Concanavalin A prevents glutamate- and quisqualateinduced receptor desensitization and the quisqualate inhibition of kainate responses
P. Lukasiewicz, J. Mcreynolds (1985)
Synaptic transmission at N‐methyl‐D‐aspartate receptors in the proximal retina of the mudpuppy.The Journal of Physiology, 367
G. Fagg, A. Foster, A. Ganong (1986)
Excitatory amino acid synaptic mechanisms and neurological functionTrends in Pharmacological Sciences, 7
J. Davies, J. Watkins (1982)
Actions of D and L forms of 2-amino-5-phosphonovalerate and 2-amino-4-phosphonobutyrate in the cat spinal cordBrain Research, 235
S. Lipton, D. Tauck (1987)
Voltage‐dependent conductances of solitary ganglion cells dissociated from the rat retina.The Journal of Physiology, 385
V. Crunelli, S. Forda, J. Kelly (1983)
Blockade of amino acid‐induced depolarizations and inhibition of excitatory post‐synaptic potentials in rat dentate gyrus.The Journal of Physiology, 341
(1984)
Antibodies against filamentous
沖中 忠一
On glutamic acid
A. Ames, D. Pollen (1969)
Neurotransmission in central nervous tissue: a study of isolated rabbit retina.Journal of neurophysiology, 32 3
F. Fonnum (1984)
Glutamate: A Neurotransmitter in Mammalian BrainJournal of Neurochemistry, 42
R. Evans, A. Francis, A. Jones, D.A.S. Smith, J. Watkins (1982)
THE EFFECTS OF A SERIES OF ω‐PHOSPHONIC α‐CARBOXYLIC AMINO ACIDS ON ELECTRICALLY EVOKED AND EXCITANT AMINO ACID‐INDUCED RESPONSES IN ISOLATED SPINAL CORD PREPARATIONSBritish Journal of Pharmacology, 75
M. Perkins, T. Stone (1982)
An iontophoretic investigation of the actions of convulsant kynurenines and their interaction with the endogenous excitant quinolinic acidBrain Research, 247
(1983)
Neurofilaments contain a - melanocypte - stimulating hormone ( a - MSH ) - like immunoreactivity
P. Nelson, R. Pun, G. Westbrook (1986)
Synaptic excitation in cultures of mouse spinal cord neurones: receptor pharmacology and behaviour of synaptic currents.The Journal of Physiology, 372
(1985)
Synaptic transmission between dorsal root
(1986)
Excitatory amino acid responses of rat
V. Perry (1979)
The ganglion cell layer of the retina of the rat: a Golgi studyProceedings of the Royal Society of London. Series B. Biological Sciences, 204
B. Ault, R. Evans, A. Francis, D. Oakes, J. Watkins (1980)
Selective depression of excitatory amino acid induced depolarizations by magnesium ions in isolated spinal cord preparations.The Journal of Physiology, 307
M. Mayer, G. Westbrook (1985)
The action of N‐methyl‐D‐aspartic acid on mouse spinal neurones in culture.The Journal of Physiology, 361
J. Hablitz, I. Langmoen (1986)
N-methyl-D-aspartate receptor antagonists reduce synaptic excitation in the hippocampus, 6
(1987)
Neural nicotinic acetylcholine responses in mammalian retinal ganglion cells
E. Fenwick, A. Marty, E. Neher (1982)
A patch‐clamp study of bovine chromaffin cells and of their sensitivity to acetylcholine.The Journal of Physiology, 331
A. Ishida, J. Neyton (1985)
Quisqualate and L-glutamate inhibit retinal horizontal-cell responses to kainate.Proceedings of the National Academy of Sciences of the United States of America, 82 6
(1986)
Concanavalin A prevents glutamate - and quisqualate - induced receptor desensitization and the quisqualate inhibition of kainate responses in isolated horizontal cells of the catfish retina
Y. Fukuda (1977)
A three-group classification of rat retinal ganglion cells: histological and physiological studiesBrain Research, 119
P. Caldwell (1970)
Calcium Chelation and Buffers
(1986)
Excitatory amino acid receptors of the retina
R. Dingledine (1986)
NMDA Receptors: what do they do?Trends in Neurosciences, 9
H. Ikeda, M. Sheardown (1982)
Aspartate may be an excitatory transmitter mediating visual excitation of ‘sustained’ but not ‘transient’ cells in the cat retina: Iontophoretic studiesin vivoNeuroscience, 7
C. Jahr, Charles Stevens (1987)
Glutamate activates multiple single channel conductances in hippocampal neuronsNature, 325
(1987)
Neural nicotinic acetylcholine responses in mammalian retinal
S. Bloomfield, J. Dowling (1985)
Roles of aspartate and glutamate in synaptic transmission in rabbit retina. I. Outer plexiform layer.Journal of neurophysiology, 53 3
L. Nowak, P. Bregestovski, P. Ascher, A. Herbet, A. Prochiantz (1984)
Magnesium gates glutamate-activated channels in mouse central neuronesNature, 307
(1981)
Aspartate aminotransferase-like
J. Johnson (1972)
Glutamic acid as a synaptic transmitter in the nervous system. A review.Brain research, 37 1
S. Cull-Candy, M. Usowicz (1987)
Multiple-conductance channels activated by excitatory amino acids in cerebellar neuronsNature, 325
MM Slaughter, Rf Miller (1983)
The role of excitatory amino acid transmitters in the mudpuppy retina: an analysis with kainic acid and N-methyl aspartate, 3
R. Altschuler, J. Mosinger, G. Harmison, M. Parakkal, R. Wenthold (1982)
Aspartate aminotransferase-like immunoreactivity as a marker for aspartate/glutamate in guinea pig photoreceptorsNature, 298
S. Berger, M. McDaniel, J. Carter, Oliver Lowry (1977)
DISTRIBUTION OF FOUR POTENTIAL TRANSMITTER AMINO ACIDS IN MONKEY RETINAJournal of Neurochemistry, 28
J. Mori-Okamoto, Y. Ikeda, J. Tatsuno (1989)
Characterization of excitatory amino acid receptors in cultured chick cerebellar neuronsNeuroscience, 28
(1986)
Excitatory amino acid synaptic mechanisms
1. The pharmacological properties of excitatory amino acid responses on ganglion cells dissociated from the rat retina were examined with the use of the whole‐cell voltage‐clamp technique. 2. L‐Glutamate at a concentration of 50 microM produced inward non‐desensitizing currents at negative holding potentials in nearly every cell tested (83%, n = 18) In physiological solutions, L‐glutamate responses reversed at approximately ‐9 mV, and higher concentrations of this agonist introduced a desensitizing component to the response. 3. At negative holding potentials, kainate (25‐125 microM) produced inward currents in all of the cells tested (n = 37). These currents never desensitized, even at high agonist concentrations, and reversed near ‐6 mV. Currents induced by 50 microM‐kainate were reversibly antagonized by kynurenate (100‐300 microM) but not by 100 microM‐2‐amino‐5‐phosphonovalerate (APV). 4. Quisqualate generated smaller, non‐desensitizing currents in only 50% of the cells tested (n = 38). Quisqualate responses reversed in polarity near ‐4 mV and were maximal at an agonist dose of 25 microM, with higher concentrations introducing a rapidly desensitizing component without a detectable increase in amplitude. Currents produced by quisqualate at a concentration of 50 microM were not antagonized by either 750 microM‐kynurenate or 100 microM‐APV. 5. N‐Methyl‐D‐aspartate (NMDA) produced inward currents at negative holding potentials in 68% of the cells tested (n = 31), but only when magnesium was excluded from the extracellular medium. NMDA currents were non‐desensitizing at agonist concentrations of up to 200 microM, with higher concentrations introducing a rapidly desensitizing component. NMDA (200 microM) responses were blocked by APV (100 microM) and kynurenate (300 microM) and reversed near ‐1 mV. 6. Responses generated by kainate (50‐125 microM) were antagonized by quisqualate (30‐250 microM). This antagonism occurred even in cells having no measurable response to quisqualate alone, suggesting the possibility that quisqualate may be acting both as an agonist, in the 50% of the cells that have the quisqualate‐specific receptor, and as an antagonist, at the kainate‐specific site on all cells.(ABSTRACT TRUNCATED AT 400 WORDS)
The Journal of Physiology – Wiley
Published: Feb 1, 1988
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