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Parkinson's disease in monozygotic twins

Parkinson's disease in monozygotic twins Recent studies of twins have demonstrated an unexpectedly low concordance of Parkinson's disease in monozygotic twins. Only two monozygotic twin pairs concordant for it have been reported. However, both pairs were atypical because of an early age at onset and other unusual features. We studied a monozygotic twin pair concordant for typical Parkinson's disease. The brothers have lived apart for forty years. The onset of tremor occurred three months apart, at age 71. The progression of the symptoms has been identical. Although one of the twins is more severely affected, both have typical manifestations of Parkinson's disease that respond well to dopaminergic medication. The occurrence of Parkinson's disease in these monozygotic twins suggests that genetic susceptibility is important in the tremordominant variety of Parkinson's disease. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annals of Neurology Wiley

Parkinson's disease in monozygotic twins

Annals of Neurology , Volume 19 (4) – Apr 1, 1986

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References (42)

Publisher
Wiley
Copyright
Copyright © 1986 American Neurological Association
ISSN
0364-5134
eISSN
1531-8249
DOI
10.1002/ana.410190421
pmid
3707096
Publisher site
See Article on Publisher Site

Abstract

Recent studies of twins have demonstrated an unexpectedly low concordance of Parkinson's disease in monozygotic twins. Only two monozygotic twin pairs concordant for it have been reported. However, both pairs were atypical because of an early age at onset and other unusual features. We studied a monozygotic twin pair concordant for typical Parkinson's disease. The brothers have lived apart for forty years. The onset of tremor occurred three months apart, at age 71. The progression of the symptoms has been identical. Although one of the twins is more severely affected, both have typical manifestations of Parkinson's disease that respond well to dopaminergic medication. The occurrence of Parkinson's disease in these monozygotic twins suggests that genetic susceptibility is important in the tremordominant variety of Parkinson's disease.

Journal

Annals of NeurologyWiley

Published: Apr 1, 1986

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