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Excitatory nature of dopamine in the nigro-caudate pathway

Excitatory nature of dopamine in the nigro-caudate pathway 221 24 24 4 4 S. T. Kitai M. Sugimori J. D. Kocsis Morin Memorial Laboratory, Department of Anatomy School of Medicine, Wayne State University Detroit USA Summary Inputs from the substantia nigra (SN) to the caudate nucleus (Cd) and the effects of electrophoretic dopamine on Cd neurones were studied in cats anaesthetized with pentobarbitone with intracellular techniques. Single shock electrical stimulation of the SN or the medial forebrain bundle (MFB) induced monosynaptic EPSPs in Cd neurones. Dopamine depolarized Cd neurones and chlorpromazine suppressed the SN or MFB induced EPSPs. Appropriate controls indicate that the drug effects were not artifactual. Some recorded neurones were identified by procion yellow dye injection as the medium-size intrinsic Cd neurones. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Experimental Brain Research Springer Journals

Excitatory nature of dopamine in the nigro-caudate pathway

Experimental Brain Research , Volume 24 (4) – Feb 1, 1976

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References (49)

Publisher
Springer Journals
Copyright
Copyright © 1976 by Springer-Verlag
Subject
Biomedicine; Neurosciences; Neurology
ISSN
0014-4819
eISSN
1432-1106
DOI
10.1007/BF00235003
Publisher site
See Article on Publisher Site

Abstract

221 24 24 4 4 S. T. Kitai M. Sugimori J. D. Kocsis Morin Memorial Laboratory, Department of Anatomy School of Medicine, Wayne State University Detroit USA Summary Inputs from the substantia nigra (SN) to the caudate nucleus (Cd) and the effects of electrophoretic dopamine on Cd neurones were studied in cats anaesthetized with pentobarbitone with intracellular techniques. Single shock electrical stimulation of the SN or the medial forebrain bundle (MFB) induced monosynaptic EPSPs in Cd neurones. Dopamine depolarized Cd neurones and chlorpromazine suppressed the SN or MFB induced EPSPs. Appropriate controls indicate that the drug effects were not artifactual. Some recorded neurones were identified by procion yellow dye injection as the medium-size intrinsic Cd neurones.

Journal

Experimental Brain ResearchSpringer Journals

Published: Feb 1, 1976

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