Access the full text.
Sign up today, get DeepDyve free for 14 days.
K. Varady, M. Hellerstein (2007)
Alternate-day fasting and chronic disease prevention: a review of human and animal trials.The American journal of clinical nutrition, 86 1
Haiming Cao, Kristin Gerhold, J. Mayers, M. Wiest, S. Watkins, G. Hotamışlıgil (2008)
Identification of a Lipokine, a Lipid Hormone Linking Adipose Tissue to Systemic MetabolismCell, 134
K. Varady, Candice Allister, D. Roohk, M. Hellerstein (2010)
Improvements in body fat distribution and circulating adiponectin by alternate-day fasting versus calorie restriction.The Journal of nutritional biochemistry, 21 3
Danica Chen, Joanne Bruno, Erin Easlon, Su-Ju Lin, Hwei-Ling Cheng, F. Alt, L. Guarente (2008)
Tissue-specific regulation of SIRT1 by calorie restriction.Genes & development, 22 13
E. Masoro (2000)
Caloric restriction and aging: an updateExperimental Gerontology, 35
R. Sohal, R. Weindruch (1996)
Oxidative Stress, Caloric Restriction, and AgingScience, 273
V. Mai, L. Colbert, D. Berrigan, S. Perkins, R. Pfeiffer, J. Lavigne, E. Lanza, D. Haines, A. Schatzkin, S. Hursting (2003)
Calorie restriction and diet composition modulate spontaneous intestinal tumorigenesis in Apc(Min) mice through different mechanisms.Cancer research, 63 8
G. Lusk (1924)
ANIMAL CALORIMETRY Twenty-Fourth Paper. ANALYSIS OF THE OXIDATION OF MIXTURES OF CARBOHYDRATE AND FATJournal of Biological Chemistry, 59
M. Kunesova, V. Hainer, E. Tvrzická, S. Phinney, V. Štich, J. Pařízková, A. Žák, A. Stunkard (2002)
Assessment of dietary and genetic factors influencing serum and adipose fatty acid composition in obese female identical twinsLipids, 37
Jina Hong, R. Stubbins, Rebekah Smith, A. Harvey, N. Núñez (2009)
Differential susceptibility to obesity between male, female and ovariectomized female miceNutrition Journal, 8
M. Hamrick, K. Ding, Sumant Ponnala, S. Ferrari, C. Isales (2008)
Caloric Restriction Decreases Cortical Bone Mass but Spares Trabecular Bone in the Mouse Skeleton: Implications for the Regulation of Bone Mass by Body WeightJournal of Bone and Mineral Research, 23
Rozalyn Anderson, D. Shanmuganayagam, R. Weindruch (2009)
Caloric Restriction and Aging: Studies in Mice and MonkeysToxicologic Pathology, 37
N. Dimopoulos, M. Watson, K. Sakamoto, H. Hundal (2006)
Differential effects of palmitate and palmitoleate on insulin action and glucose utilization in rat L6 skeletal muscle cells.The Biochemical journal, 399 3
D. Sinclair (2005)
Toward a unified theory of caloric restriction and longevity regulationMechanisms of Ageing and Development, 126
J. Dhahbi, H. Kim, P. Mote, R. Beaver, S. Spindler (2004)
Temporal linkage between the phenotypic and genomic responses to caloric restriction.Proceedings of the National Academy of Sciences of the United States of America, 101 15
M. López-Torres, R. Gredilla, A. Sanz, G. Barja (2002)
Influence of aging and long-term caloric restriction on oxygen radical generation and oxidative DNA damage in rat liver mitochondria.Free radical biology & medicine, 32 9
Scott Turner, Elizabeth Murphy, R. Neese, Fernando Antelo, Tiffany Thomas, A. Agarwal, C. Go, M. Hellerstein (2003)
Measurement of TG synthesis and turnover in vivo by 2H2O incorporation into the glycerol moiety and application of MIDA.American journal of physiology. Endocrinology and metabolism, 285 4
P. Duffy, R. Feuers, J. Leakey, Kenjid Nakamura, A. Turturro, R. Hart (1989)
Effect of chronic caloric restriction on physiological variables related to energy metabolism in the male Fischer 344 ratMechanisms of Ageing and Development, 48
M. Kunešová, R. Braunerová, P. Hlavaty, E. Tvrzická, B. Staňková, Jan Škrha, J. Hilgertová, Martin Hill, J. Kopecký, M. Wagenknecht, V. Hainer, Martin Matoulek, J. Pařízková, A. Žák, Štěpán Svačina (2006)
The influence of n-3 polyunsaturated fatty acids and very low calorie diet during a short-term weight reducing regimen on weight loss and serum fatty acid composition in severely obese women.Physiological research, 55 1
Yves Schutz (2004)
Concept of fat balance in human obesity revisited with particular reference to de novo lipogenesisInternational Journal of Obesity, 28
K. Westerterp (1993)
Food quotient, respiratory quotient, and energy balance.The American journal of clinical nutrition, 57 5 Suppl
W. Nelson, F. Halberg (1986)
Meal-timing, circadian rhythms and life span of mice.The Journal of nutrition, 116 11
G. López-Lluch, P. Irusta, P. Navas, R. Cabo (2008)
Mitochondrial biogenesis and healthy agingExperimental Gerontology, 43
(1924)
Analysis of the oxidation of mixtures of carbohydrate and fat: a Correction
E. Parks, L. Skokan, M. Timlin, C. Dingfelder (2008)
Dietary sugars stimulate fatty acid synthesis in adults.The Journal of nutrition, 138 6
(2005)
Isotope Tracers in Metabolic Research
S. Watkins, Peter Reifsnyder, H. Pan, J. German, E. Leiter (2002)
Lipid metabolome-wide effects of the PPARγ agonist rosiglitazones⃞s The online version of this article (available at http://www.jlr.org) contains an additional 4 tables. Published, JLR Papers in Press, August 16, 2002. DOI 10.1194/jlr.M200169-JLR200Journal of Lipid Research, 43
M. Chong, L. Hodson, A. Bickerton, R. Roberts, M. Neville, F. Karpe, K. Frayn, B. Fielding (2008)
Parallel activation of de novo lipogenesis and stearoyl-CoA desaturase activity after 3 d of high-carbohydrate feeding.The American journal of clinical nutrition, 87 4
R. Gredilla, G. Barja (2005)
Minireview: the role of oxidative stress in relation to caloric restriction and longevity.Endocrinology, 146 9
Y. Kushnareva, A. Murphy, A. Andreyev (2002)
Complex I-mediated reactive oxygen species generation: modulation by cytochrome c and NAD(P)+ oxidation-reduction state.The Biochemical journal, 368 Pt 2
S. Cao, J. Dhahbi, P. Mote, S. Spindler (2001)
Genomic profiling of short- and long-term caloric restriction effects in the liver of aging miceProceedings of the National Academy of Sciences of the United States of America, 98
L. Heilbronn, E. Ravussin (2003)
Calorie restriction and aging: review of the literature and implications for studies in humans.The American journal of clinical nutrition, 78 3
B. Merry (2002)
Molecular mechanisms linking calorie restriction and longevity.The international journal of biochemistry & cell biology, 34 11
T. Tsuchiya, J. Dhahbi, Xinping Cui, P. Mote, A. Bartke, S. Spindler (2004)
Additive regulation of hepatic gene expression by dwarfism and caloric restriction.Physiological genomics, 17 3
J. Volek, S. Phinney, C. Forsythe, E. Quann, R. Wood, M. Puglisi, W. Kraemer, D. Bibus, M. Fernández, R. Feinman (2009)
Carbohydrate Restriction has a More Favorable Impact on the Metabolic Syndrome than a Low Fat DietLipids, 44
L. Guarente (2008)
Mitochondria—A Nexus for Aging, Calorie Restriction, and Sirtuins?Cell, 132
T. Wetter, A. Gazdag, D. Dean, G. Cartee (1999)
Effect of calorie restriction on in vivo glucose metabolism by individual tissues in rats.American journal of physiology. Endocrinology and metabolism, 276 4
Jacob Mulligan, Annette Stewart, K. Saupe (2008)
Downregulation of plasma insulin levels and hepatic PPARγ expression during the first week of caloric restriction in miceExperimental Gerontology, 43
R. Colman, Grace Nam, Lori Huchthausen, Jacob Mulligan, K. Saupe (2007)
Energy restriction-induced changes in body composition are age specific in mice.The Journal of nutrition, 137 10
E. Masoro, R. McCarter, M. Katz, C. Mcmahan (1992)
Dietary restriction alters characteristics of glucose fuel use.Journal of gerontology, 47 6
W. Lee, S. Bassilian, Z. Guo, D. Schoeller, J. Edmond, E. Bergner, L. Byerley (1994)
Measurement of fractional lipid synthesis using deuterated water (2H2O) and mass isotopomer analysis.The American journal of physiology, 266 3 Pt 1
S. Watkins, Peter Reifsnyder, H. Pan, J. German, E. Leiter (2002)
Lipid metabolome-wide effects of the PPARgamma agonist rosiglitazone.Journal of lipid research, 43 11
Elsa Brochmann, M. Duarte, Hasan Zaidi, S. Murray (2003)
Effects of dietary restriction on total body, femoral, and vertebral bone in SENCAR, C57BL/6, and DBA/2 mice.Metabolism: clinical and experimental, 52 10
S. Bassilian, S. Ahmed, Shu Lim, L. Boros, C. Mao, W. Lee (2002)
Loss of regulation of lipogenesis in the Zucker diabetic rat. II. Changes in stearate and oleate synthesis.American journal of physiology. Endocrinology and metabolism, 282 3
A. Strawford, Fernando Antelo, M. Christiansen, M. Hellerstein (2004)
Adipose tissue triglyceride turnover, de novo lipogenesis, and cell proliferation in humans measured with 2H2O.American journal of physiology. Endocrinology and metabolism, 286 4
S. Spindler, J. Dhahbi (2007)
Conserved and tissue-specific genic and physiologic responses to caloric restriction and altered IGFI signaling in mitotic and postmitotic tissues.Annual review of nutrition, 27
D. Berrigan, J. Lavigne, S. Perkins, T. Nagy, J. Barrett, S. Hursting (2005)
Phenotypic effects of calorie restriction and insulin-like growth factor-1 treatment on body composition and bone mineral density of C57BL/6 mice: implications for cancer prevention.In vivo, 19 4
J Flatt (1995)
Body composition, respiratory quotient, and weight maintenance.The American journal of clinical nutrition, 62 5 Suppl
Abstract Calorie restriction (CR) increases longevity and retards the development of many chronic diseases, but the underlying metabolic signals are poorly understood. Increased fatty acid (FA) oxidation and reduced FA synthesis have been hypothesized to be important metabolic adaptations to CR. However, at metabolic steady state, FA oxidation must match FA intake plus synthesis; moreover, FA intake is low, not high, during CR. Therefore, it is not clear how FA dynamics are altered during CR. Accordingly, we measured food intake patterns, whole body fuel selection, endogenous FA synthesis, and gene expression in mice on CR. Within 2 days of CR being started, a shift to a cyclic, diurnal pattern of whole body FA metabolism occurred, with an initial phase of elevated endogenous FA synthesis respiratory exchange ratio (RER) >1.10, lasting 4–6 h after food provision, followed by a prolonged phase of FA oxidation (RER = 0.70, lasting 18–20 h). CR mice oxidized four times as much fat per day as ad libitum (AL)-fed controls (367 ± 19 vs. 97 ± 14 mg/day, P < O.001) despite reduced energy intake from fat. This increase in FA oxidation was balanced by a threefold increase in adipose tissue FA synthesis compared with AL. Expression of FA synthase and acetyl-CoA carboxylase mRNA were increased in adipose and liver in a time-dependent manner. We conclude that CR induces a surprising metabolic pattern characterized by periods of elevated FA synthesis alternating with periods of FA oxidation disproportionate to dietary FA intake. This pattern may have implications for oxidative damage and disease risk. fat synthesis lipogenesis palmitoleate heavy water Copyright © 2010 the American Physiological Society
AJP - Endocrinology and Metabolism – The American Physiological Society
Published: Jan 1, 2010
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.