Access the full text.
Sign up today, get DeepDyve free for 14 days.
Loading next page...
/lp/wiley/brain-da-d2-receptors-predict-reinforcing-effects-of-stimulants-in-CxttBtbki9
References (25)
-
P. Sokoloff, J. Schwartz (1995)
Novel dopamine receptors half a decade later.Trends in pharmacological sciences, 16 8
-
K. Blum, P. Sheridan, R. Wood, E. Braverman, T. Chen, J phd, D. Comings (1996)
The D2 Dopamine Receptor Gene as a Determinant of Reward Deficiency SyndromeJournal of the Royal Society of Medicine, 89
-
N. Volkow, Gene-Jack Wang, Joanna Fowler, J. Logan, Burton Angrist, R. Hitzemann, Jeffrey Lieberman, N. Pappas (1997)
Effects of methylphenidate on regional brain glucose metabolism in humans: relationship to dopamine D2 receptors.The American journal of psychiatry, 154 1
-
Noble Noble, Blum Blum, Ritchie Ritchie, Montgomery Montgomery, Sheridan Sheridan (1991)
Allelic association of the D2 dopamine receptor‐binding characteristics in alcoholismArch Gen Psychiatry, 48
-
P. Piazza, F. Rougé-Pont, J. Deminière, Martine Kharoubi, M. Moal, H. Simon (1991)
Dopaminergic activity is reduced in the prefrontal cortex and increased in the nucleus accumbens of rats predisposed to develop amphetamine self-administrationBrain Research, 567
-
N. Volkow, Linda Chang, Gene-Jack Wang, J. Fowler, Y-S. Ding, M. Sedler, J. Logan, D. Franceschi, J. Gatley, R. Hitzemann, A. Gifford, Christopher Wong, N. Pappas (2001)
Low level of brain dopamine D2 receptors in methamphetamine abusers: association with metabolism in the orbitofrontal cortex.The American journal of psychiatry, 158 12
-
(1990)
Graphical analysis of reversible binding from time activity measurements -
N. Srinivas, J. Hubbard, D. Quinn, E. Korchinski, K. Midha (1991)
Extensive and enantioselective presystemic metabolism of dl-threo-methylphenidate in humansProgress in Neuro-Psychopharmacology and Biological Psychiatry, 15
-
N. Volkow, Gene-Jack Wang, J. Fowler, R. Hitzemann, B. Angrist, S. Gatley, J. Logan, Yu-Shin Ding, N. Pappas (1999)
Association of methylphenidate-induced craving with changes in right striato-orbitofrontal metabolism in cocaine abusers: implications in addiction.The American journal of psychiatry, 156 1
-
M. Ritz, R. Lamb, S. Goldberg, M. Kuhar (1987)
Cocaine receptors on dopamine transporters are related to self-administration of cocaine.Science, 237 4819
-
D. Goldman, M. Urbanek, D. Guenther, R. Robin, J. Long (1998)
A functionally deficient DRD2 variant [Ser311Cys] is not linked to alcoholism and substance abuse.Alcohol, 16 1
-
E. Noble, K. Blum, T. Ritchie, A. Montgomery, P. Sheridan (1991)
Allelic association of the D2 dopamine receptor gene with receptor-binding characteristics in alcoholism.Archives of general psychiatry, 48 7
-
Papp Papp, Klimek Klimek, Willner Willner (1994)
Parallel changes in dopamine D2 receptor binding in limbic forebrain associated with chronic mild stress‐induced anhedonia and its reversal by imipraminePsychopharmacology (Berl), 115
-
D. Morgan, K. Grant, H. Gage, R. Mach, J. Kaplan, Osric Prioleau, S. Nader, N. Buchheimer, R. Ehrenkaufer, M. Nader (2002)
Social dominance in monkeys: dopamine D2 receptors and cocaine self-administrationNature Neuroscience, 5
-
N. Volkow, Gene-Jack Wang, J. Fowler, J. Logan, D. Schlyer, R. Hitzemann, J. Lieberman, B. Angrist, N. Pappas, R. Macgregor, G. Burr, T. Cooper, A. Wolf (1994)
Imaging endogenous dopamine competition with [11C]raclopride in the human brainSynapse, 16
-
N. Volkow, J. Fowler, Gene-Jack Wang, R. Hitzemann, J. Logan, D. Schlyer, S. Dewey, A. Wolf (1993)
Decreased dopamine D2 receptor availability is associated with reduced frontal metabolism in cocaine abusersSynapse, 14
-
P. Thanos, N. Volkow, P. Freimuth, H. Umegaki, H. Ikari, G. Roth, D. Ingram, R. Hitzemann (2001)
Overexpression of dopamine D2 receptors reduces alcohol self‐administrationJournal of Neurochemistry, 78
-
N. Volkow, Gene-Jack Wang, J. Fowler, J. Logan, S. Gatley, A. Gifford, R. Hitzemann, Yu-Shin Ding, N. Pappas (1999)
Prediction of reinforcing responses to psychostimulants in humans by brain dopamine D2 receptor levels.The American journal of psychiatry, 156 9
-
N. Volkow, Gene-Jack Wang, J. Fowler, J. Logan, R. Hitzemann, R. Hitzemann, Yu-Shin Ding, N. Pappas, C. Shea, K. Piscani (1996)
Decreases in dopamine receptors but not in dopamine transporters in alcoholics.Alcoholism, clinical and experimental research, 20 9
-
S. Glick, J. Raucci, S. Wang, R. Keller, J. Carlson (1994)
Neurochemical predisposition to self-administer cocaine in rats: individual differences in dopamine and its metabolitesBrain Research, 653
-
N. Volkow, J. Fowler, Gene-Jack Wang, S. Dewey, D. Schlyer, R. Macgregor, J. Logan, D. Alexoff, C. Shea, R. Hitzemann, B. Angrist, A. Wolf (1993)
Reproducibility of repeated measures of carbon-11-raclopride binding in the human brain.Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 34 4
-
J. Logan, Joanna Fowler, N. Volkow, A. Wolf, S. Dewey, D. Schlyer, R. Macgregor, R. Hitzemann, Bernard Bendriem, S. Gatley, D. Christman (1990)
Graphical Analysis of Reversible Radioligand Binding from Time—Activity Measurements Applied to [N-11C-Methyl]-(−)-Cocaine PET Studies in Human SubjectsJournal of Cerebral Blood Flow & Metabolism, 10
-
E. Davidson, J. Finch, S. Schenk (1993)
Variability in subjective responses to cocaine: initial experiences of college students.Addictive behaviors, 18 4
-
J. Logan, N. Volkow, Joanna Fowler, Gene-Jack Wang, S. Dewey, R. Macgregor, D. Schlyer, S. Gatley, N. Pappas, P. King, R. Hitzemann, S. Vitkun (1994)
Effects of Blood Flow on [11C]Raclopride Binding in the Brain: Model Simulations and Kinetic Analysis of PET DataJournal of Cerebral Blood Flow & Metabolism, 14
-
Gene-Jack Wang, N. Volkow, J. Fowler, J. Logan, N. Abumrad, R. Hitzemann, N. Pappas, K. Pascani (1997)
Dopamine D2 Receptor Availability in Opiate-Dependent Subjects before and after Naloxone-Precipitated WithdrawalNeuropsychopharmacology, 16
- Publisher
- Wiley
- Copyright
- Copyright © 2002 Wiley‐Liss, Inc.
- ISSN
- 0887-4476
- eISSN
- 1098-2396
- DOI
- 10.1002/syn.10137
- pmid
- 12211085
- Publisher site
- See Article on Publisher Site
Abstract
We had shown that striatal DA D2 receptors levels predicted the reinforcing responses to the psychostimulant drug methylphenidate in nondrug‐abusing subjects. Here, we assessed the replicability of this finding. We measured D2 receptors with PET and (11C)raclopride (twice to determine stability) in seven nondrug‐abusing subjects to assess if they predicted the self‐reports of “drug‐liking” to intravenous methylphenidate (0.5 mg/kg). DA D2 measures were significantly correlated with “drug‐liking” in both evaluations (r = 0.82 and r = 0.78); subjects with the lowest levels reported the higher ratings of “drug‐liking” and vice versa. These results replicate our previous findings and provide further evidence that striatal DA D2 receptors modulate reinforcing responses to stimulants in humans and may underlie predisposition for drug self‐administration. Synapse 46:79–82, 2002. © 2002 Wiley‐Liss, Inc.
Journal
Synapse – Wiley
Published: Nov 1, 2002