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G. Mancini, A. Carbonara, J. Heremans (1965)
Immunochemical quantitation of antigens by single radial immunodiffusion.Immunochemistry, 2 3
S. Stewart, E. Lovelace, J. Whang, V. Ngu (1965)
BURKITT TUMOR: TISSUE CULTURE, CYTOGENETIC AND VIRUS STUDIES.Journal of the National Cancer Institute, 34
(1967)
Genetic studies of the heavy chain subgroups of y-G globulin
L. Dmochowski, C. Grey, J. Sykes, C. Shullenberger, C. Howe (1959)
Studies on Human Leukemia.∗Proceedings of the Society for Experimental Biology and Medicine, 101
H. Eagle (1959)
Amino acid metabolism in mammalian cell cultures.Science, 130 3373
J. Sinkovics, J. Sykes, C. Shullenberger, C. Howe (1967)
Patterns of growth in cultures deriving from human leukemic sources.Texas reports on biology and medicine, 25 3
S. Cohen (1965)
NOMENCLATURE OF HUMAN IMMUNOGLOBULINS.Immunology, 8
J. Pontén (1967)
Spontaneous lymphoblastoid transformation of long‐term cell cultures from human malignant lymphomaInternational Journal of Cancer, 2
B. Clarkson, A. Strife, É. Harven (1967)
Continuous culture of seven new cell lines (SK‐L1 to 7) from patients with acute leukemiaCancer, 20
L. Hayflick (1965)
THE LIMITED IN VITRO LIFETIME OF HUMAN DIPLOID CELL STRAINS.Experimental cell research, 37
M. Benyesh-Melnick, D. Fernbach, Raymond Lewis (1963)
STUDIES ON HUMAN LEUKEMIA. I. SPONTANEOUS LYMPHOBLASTOID TRANSFORMATION OF FIBROBLASTIC BONE MARROW CULTURES DERIVED FROM LEUKEMIC AND NONLEUKEMIC CHILDREN.Journal of the National Cancer Institute, 31
R. Pulvertaft (1964)
CYTOLOGY OF BURKITT'S TUMOUR (AFRICAN LYMPHOMA).Lancet, 1 7327
L. Philipson, J. Killander, P. Albertsson (1966)
Interaction between poliovirus and immunoglobulins. I. Detection of virus antibodies by partition in aqueous polymer phase systems.Virology, 28 1
A. Rabson, G. O'conor, S. Baron, J. Whang, F. Legallais (1966)
Morphologic, cytogenetic and virologic studies in vitro of a malignant lymphoma from an African childInternational Journal of Cancer, 1
M. Epstein, Y. Barr, B. Achong (1966)
Preliminary observations on new lymphoblast strains (EB4, EB5) from Burkitt tumours in a British and a Ugandan patient.British Journal of Cancer, 20
D. Armstrong (1966)
Serial Cultivation of Human Leukemic Cells.∗Proceedings of the Society for Experimental Biology and Medicine, 122
J. Fahey, I. Finegold, A. Rabson, R. Manaker (1966)
Immunoglobulin Synthesis in vitro by Established Human Cell LinesScience, 152
Philipson Philipson, Pontén Pontén (1967)
Immunoglobulin synthesis after lymphoblastoid transformation of long term cultures from Hodgkin's diseaseLife Sciences, 6
J. Trujillo, B. List-Young, J. Butler, C. Shullenberger, C. Gott (1966)
Long-term Culture of Lymph Node Tissue from a Patient with Lymphocytic LymphomaNature, 209
C. Laurell (1965)
ANTIGEN-ANTIBODY CROSSED ELECTROPHORESIS.Analytical biochemistry, 10
(1966)
Interaction between poliovirus and immunologlobulins
F. Jensen, R. Gwatkin, J. Biggers (1964)
A SIMPLE ORGAN CULTURE METHOD WHICH ALLOWS SIMULTANEOUS ISOLATION OF SPECIFIC TYPES OF CELLS.Experimental cell research, 34
M. Epstein, Y. Barr (1965)
CHARACTERISTICS AND MODE OF GROWTH OF TISSUE CULTURE STRAIN (EB1) OF HUMAN LYMPHOBLASTS FROM BURKITT'S LYMPHOMA.Journal of the National Cancer Institute, 34
E. Saksela, J. Pontén (1968)
Chromosomal changes of immunoglobulin-producing cell lines from human lymph nodes with and without lymphoma.Journal of the National Cancer Institute, 41 2
L. Hayflick, P. Moorhead (1961)
The serial cultivation of human diploid cell strains.Experimental cell research, 25
J. Trujillo, MD BUTLER, Phd AHEARN, MD Shullenberger, MA LIST-YOUNG, M. Gom, MD Anstall, A. Shively, Burroughs Chlorambucil, Wellcome (1967)
Long‐term culture of lymph node tissue from a patient with lymphocytic lymphoma. II. Preliminary ultrastructural, immunofluorescence and cytogenetic studiesCancer, 20
G. Moore, R. Gerner, H. Franklin (1967)
Culture of normal human leukocytes.JAMA, 199 8
N. Tanigaki, Y. Yagi, G. Moore, D. Pressman (1966)
Immunoglobulin production in human leukemia cell lines.Journal of immunology, 97 5
L. Philipson, J. Pontén (1967)
Immunoglobulin synthesis in long term cultures of lymph nodes from Hodgkin's disease.Life sciences, 6 24
M. Epstein, Y. Barr, B. Achong (1965)
The Behaviour and Morphology of a Second Tissue Culture Strain (EB2) of Lymphoblasts from Burkitt's LymphomaBritish Journal of Cancer, 19
G. Foley, H. Lazarus, S. Farber, B. Uzman, B. Boone, R. McCarthy (1965)
Continuous culture of human lymphoblasts from peripheral blood of a child with acute leukemiaCancer, 18
John Brooke, E. Osgood (1959)
Long-term mixed cultures of human hemic cells, with granulocytic, lymphocytic, plasmocytic and erythrocytic series represented.Blood, 14 7
Fifteen human lymph nodes have been grown in vitro. Cells from seven of the nodes eventually developed into apparently permanent lines dominated by cells resembling lymphoblasts. When the results are combined with a previously published series (Pontén, 1967) no difference is found between the frequency at which the phenomenon occurs in lymph nodes obtained from patients without known malignancy (group L), from nodes draining carcinomas (group C), or from malignant lymphomas (group M). It is concluded that the spontaneous establishment of permanent lymphoid cell lines is a characteristic of human lymphoid tissue in general and that no relationship to malignant lymphoma has been proved. A random fibroblastoid growth, apparently unrelated to the appearance of a secondary lymphoid cell production phase, was observed in eight cases, seven of which belonged to group M or C. Five of seven lines were tested repeatedly for globulin production by immunoelectrophoresis and immunoprecipitation combined with autoradiography. Four lines produced immunoglobulins of the IgG type; the fifth, obtained from a tuberculous node, synthesized IgA. Each cell line produced only one detectable molecular species, suggesting a monoclonal origin of the immunoglobulins. The light chains were exclusively of the kappa type, whereas the heavy chains differed with respect to their subgroup specificity.
International Journal of Cancer – Wiley
Published: Mar 15, 1968
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