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H. Carson, K. Kaneshiro (1976)
DROSOPHILA OF HAWAII: SYSTEMATICS AND ECOLOGICAL GENETICS!Annual Review of Ecology, Evolution, and Systematics, 7
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H Yang, MR Wheeler (1969)
Studies in Genetics
K. Paigen, M. Meisler, J. Felton, V. Chapman (1976)
Genetic determination of the β-galactosidase developmental program in mouse liverCell, 9
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W. Dickinson, H. Carson (1979)
Regulation of the tissue specificity of an enzyme by a cis-acting genetic element: evidence from interspecific Drosophila hybrids.Proceedings of the National Academy of Sciences of the United States of America, 76 9
R. Andres (1976)
Aldehyde oxidase and xanthine dehydrogenase from wild-type Drosophila melanogaster and immunologically cross-reacting material from ma-1 mutants. Purification by immunoadsorption and characterization.European journal of biochemistry, 62 3
W. Dickinson (1978)
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WJ Dickinson (1979)
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James Thompson, M. Ashburner, R. Woodruff (1977)
Presumptive control mutation for alcohol dehydrogenase in Drosophila melanogasterNature, 270
K Paigen (1979)
Physiological Genetics
M Schwartz, T O'Donnell, W Sofer (1975)
Isozymes I. Molecular Structure
Drosophila heteroneura and D differens are closely related, interfertile species of the Hawaiian picture‐winged group. They display marked qualitative and quantitative differences in the pattern of expression of alcohol dehydrogenase (ADH) and an aldehyde oxidase (AO‐1). These presumptive regulatory differences are revealed by comparisons of the relative levels of these enzymes in various tissues in larvae and adults. In hybrids produced between parents carrying different electrophoretic alleles at the structural loci for these two enzymes, each allele is expressed according to the developmental program characteristic of the parent from which it was derived. This result indicates control of the differences in pattern of expression by one or more cis‐acting sites associated with each structural locus. The distribution of activity among all the three forms of these dimeric enzymes produced in hybrids indicates that the pattern differences reflect differential accumulation of enzyme molecules, not altered catalytic properties. As expected, the regulatory differences segregate with the electrophoretic markers in backcrosses.
Genesis: the Journal of Genetics and Development – Wiley
Published: Jan 1, 1979
Keywords: ; ; ; ;
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