Access the full text.
Sign up today, get DeepDyve free for 14 days.
F. Ali, T. Babar, N. Rama, P. Jones (2009)
3-(3-Bromobenzyl)isoquinolin-1(2H)-oneActa Crystallographica Section E: Structure Reports Online, 66
Lianhai Li, Waepril Chua (2011)
One-pot multistep synthesis of 3,4-fused isoquinolin-1(2H)-one analogsTetrahedron Letters, 52
S. Shafi, Mohammad Alam, Naveen Mulakayala, Chaitanya Mulakayala, G. Vanaja, Arunasree Kalle, Reddanna Pallu, M. Alam (2012)
Synthesis of novel 2-mercapto benzothiazole and 1,2,3-triazole based bis-heterocycles: their anti-inflammatory and anti-nociceptive activities.European journal of medicinal chemistry, 49
A. Katsori, M. Chatzopoulou, K. Dimas, C. Kontogiorgis, A. Patsilinakos, T. Trangas, D. Hadjipavlou-Litina (2011)
Curcumin analogues as possible anti-proliferative & anti-inflammatory agents.European journal of medicinal chemistry, 46 7
A. Tan, M. Berridge (2000)
Superoxide produced by activated neutrophils efficiently reduces the tetrazolium salt, WST-1 to produce a soluble formazan: a simple colorimetric assay for measuring respiratory burst activation and for screening anti-inflammatory agents.Journal of immunological methods, 238 1-2
R. Tonk, Sandhya Bawa, G. Chawla, G. Deora, Suresh Kumar, V. Rathore, Naveen Mulakayala, Azad Rajaram, Arunasree Kalle, O. Afzal (2012)
Synthesis and pharmacological evaluation of pyrazolo[4,3-c]cinnoline derivatives as potential anti-inflammatory and antibacterial agents.European journal of medicinal chemistry, 57
A. Katsori, M. Chatzopoulou, K. Dimas, C. Kontogiorgis, A. Patsilinakos, T. Trangas, D. Hadjipavlou-Litina (2011)
Curcumin Analogues as Possible anti-Proliferative and Antiinflammatory Agents.ChemInform, 42
F. Coelho, D. Veronese, Elizandra Lopes, R. Rossi (2003)
An approach to substituted dihydroisoquinolin-1(2H)-ones from Baylis–Hillman adductsTetrahedron Letters, 44
J. Guastavino, S. Barolo, R. Rossi (2006)
One‐Pot Synthesis of 3‐Substituted Isoquinolin‐1‐(2H)‐ones and Fused Isoquinolin‐1‐(2H)‐ones by SRN1 Reactions in DMSOEuropean Journal of Organic Chemistry, 2006
G. Kohlhagen, K. Paull, M. Cushman, P. Nagafuji, Y. Pommier (1998)
Protein-linked DNA strand breaks induced by NSC 314622, a novel noncamptothecin topoisomerase I poison.Molecular pharmacology, 54 1
V. Viswanadhan, A. Ghose, G. Revankar, R. Robins (1989)
Atomic physicochemical parameters for three dimensional structure directed quantitative structure-activity relationships. 4. Additional parameters for hydrophobic and dispersive interactions and their application for an automated superposition of certain naturally occurring nucleoside antibioticsJ. Chem. Inf. Comput. Sci., 29
M. Löhn, O. Plettenburg, Y. Ivashchenko, A. Kannt, Armin Hofmeister, D. Kadereit, M. Schaefer, W. Linz, M. Kohlmann, J. Herbert, P. Janiak, S. O'Connor, H. Ruetten (2009)
Pharmacological Characterization of SAR407899, a Novel Rho-Kinase InhibitorHypertension, 54
V. Glushkov, Yu. Shklyaev (2001)
Synthesis of 1(2H)-Isoquinolones. (Review)Chemistry of Heterocyclic Compounds, 37
H. Ouchi, Yoko Kawata, M. Ono, Y. Morita, Yutaka Yamamoto, H. Takahata (2004)
Regioselective Aromatic Substitution of 6,8-Dihydroxy-4-ethoxycarbonyl-2H-isoquinolin-1-one Derivatives Using the Stille Coupling Reaction.ChemInform, 35
Yasutomi Asano, Shuji Kitamura, Taiichi Ohra, F. Itoh, M. Kajino, Tomoko Tamura, M. Kaneko, S. Ikeda, H. Igata, T. Kawamoto, S. Sogabe, S. Matsumoto, Toshimasa Tanaka, M. Yamaguchi, H. Kimura, S. Fukumoto (2008)
Discovery, synthesis and biological evaluation of isoquinolones as novel and highly selective JNK inhibitors (2).Bioorganic & medicinal chemistry, 16 8
Frank Wu, F. Büttner, Rhonda Chen, E. Hickey, S. Jakes, P. Kaplita, M. Kashem, Steven Kerr, S. Kugler, Z. Paw, Anthony Prokopowicz, C. Shih, R. Snow, E. Young, C. Cywin (2010)
Substituted 2H-isoquinolin-1-one as potent Rho-Kinase inhibitors. Part 1: Hit-to-lead account.Bioorganic & medicinal chemistry letters, 20 11
R. Snow, M. Cardozo, T. Morwick, C. Busacca, Yong Dong, R. Eckner, S. Jacober, S. Jakes, S. Kapadia, S. Lukas, M. Panzenbeck, G. Peet, J. Peterson, Anthony Prokopowicz, R. Sellati, Robert Tolbert, M. Tschantz, N. Moss (2002)
Discovery of 2-phenylamino-imidazo[4,5-h]isoquinolin-9-ones: a new class of inhibitors of lck kinase.Journal of medicinal chemistry, 45 16
D. Clark (1999)
Rapid calculation of polar molecular surface area and its application to the prediction of transport phenomena. 1. Prediction of intestinal absorption.Journal of pharmaceutical sciences, 88 8
J. Rigby, U. Maharoof, Mary Mateo (2000)
Studies on the narciclasine alkaloids: Total synthesis of (+)- narciclasine and (+)-pancratistatinJournal of the American Chemical Society, 122
V. Tyagi, S. Khan, A. Giri, H. Gauniyal, B. Sridhar, P. Chauhan (2012)
A ligand-free Pd-catalyzed cascade reaction: an access to the highly diverse isoquinolin-1(2H)-one derivatives via isocyanide and Ugi-MCR synthesized amide precursors.Organic letters, 14 12
(1985)
Rapid calculation of electronic effects in organic molecules
R. Polisson (1996)
Nonsteroidal anti-inflammatory drugs: practical and theoretical considerations in their selection.The American journal of medicine, 100 2A
Med Chem Res
S. Li, M. Nair, D. Edwards, R. Kisliuk, Y. Gaumont, I. Dev, D. Duch, J. Humphreys, G. Smith, R. Ferone (1991)
Folate analogues. 35. Synthesis and biological evaluation of 1-deaza, 3-deaza, and bridge-elongated analogues of N10-propargyl-5,8-dideazafolic acid.Journal of medicinal chemistry, 34 9
G. Pettit, Y. Meng, D. Herald, Keith Graham, R. Pettit, D. Doubek (2003)
Isolation and structure of ruprechstyril from Ruprechtia tangarana.Journal of natural products, 66 8
T. Hudlický, U. Rinner, D. Gonzalez, H. Akgun, Stefan Schilling, Peter Siengalewicz, Theodore Martinot, G. Pettit (2002)
Total synthesis and biological evaluation of Amaryllidaceae alkaloids: narciclasine, ent-7-deoxypancratistatin, regioisomer of 7-deoxypancratistatin, 10b-epi-deoxypancratistatin, and truncated derivatives.The Journal of organic chemistry, 67 25
K. Simonsen, K. Juhl, B. Steiniger-Brach, S. Nielsen (2010)
Novel NK(3) receptor antagonists for the treatment of schizophrenia and other CNS indications.Current opinion in drug discovery & development, 13 4
R. Siddiqui, D. English, K. Harvey, Yi Cui, M. Martin, John Wentland, L. Akard, J. Jansen, James Thompson, Joe Garcia (1995)
Phorbol ester‐induced priming of superoxide generation by phosphatidic acid‐stimulated neutrophils and granule‐free neutrophil cytoplastsJournal of Leukocyte Biology, 58
M. Waring, Taibi Ben-Hadda, A. Kotchevar, A. Ramdani, R. Touzani, S. Elkadiri, A. Hakkou, M. Bouakka, T. Ellis (2002)
2,3-Bifunctionalized Quinoxalines: Synthesis, DNA Interactions and Evaluation of Anticancer, Anti-tuberculosis and Antifungal ActivityMolecules : A Journal of Synthetic Chemistry and Natural Product Chemistry, 7
M. Mokrosz, J. Mokrosz, B. Duszyńska, A. Dereń-Wesołek, A. Kłodzińska, P. Kowalski, S. Charakchieva‐Minol, E. Tatarczyńska, T. Kowalska, Z. Majka, E. Chojnacka-wójcik, S. Misztal (1997)
5-HT1A and 5-HT2A receptor affinity and functional profile of some N-[3-(4-aryl-1-piperazinyl)propyl] derivatives of indolin-2(1H)-one, quinolin-2(1 H)-one and isoquinolin-1(2H)-one. Part 30: Structure-activity relationship studies of CNS agents.Die Pharmazie, 52 6
Zhuo Feng, Yong-cheng Lin (2006)
Marinamide, a novel alkaloid and its methyl ester produced by the application of mixed fermentation technique to two mangrove endophytic fungi from the South China SeaChinese Science Bulletin, 51
Mohammad Assarzadeh, A. Almasirad, A. Shafiee, Mansur Koopaei, M. Abdollahi (2014)
Synthesis of new thiazolo[3,2-b][1,2,4]triazole-6(5H)-one derivatives as potent analgesic and anti-inflammatory agentsMedicinal Chemistry Research, 23
Christopher, A. Lipinski, Beryl, W. Dominy, Paul, J. Feeney (2001)
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings.Advanced drug delivery reviews, 46 1-3
Y. Aly, A. Galal, L. Wong, E. Fu, F. Lin, F. Duah, P. Schiff (1989)
A revision of the structure of the isoquinolone alkaloid thalflavinePhytochemistry, 28
H. Heaney*, K. Shuhaibar (1995)
New Routes to Acyliminium Ion Precursors and a Synthesis of the Nuevamine SkeletonSynlett, 1995
P. Henson, R. Murphy (1990)
Mediators of the Inflammatory Process
J. Seydel (1985)
QSAR and strategies in the design of bioactive compounds
R. Paramashivappa, P. Kumar, P. Rao, A. Rao (2003)
Design, synthesis and biological evaluation of benzimidazole/benzothiazole and benzoxazole derivatives as cyclooxygenase inhibitors.Bioorganic & medicinal chemistry letters, 13 4
B. Krane, M. Shamma (1982)
The Isoquinolone AlkaloidsJournal of Natural Products, 45
Y. Bansal, Purva Sethi, G. Bansal (2013)
Coumarin: a potential nucleus for anti-inflammatory moleculesMedicinal Chemistry Research, 22
J. Masferrer, Bs Zweifel, Pt Manning, Sd Hauser, Km Leahy, W. Smith, P. Isakson, K. Seibert (1994)
Selective inhibition of inducible cyclooxygenase 2 in vivo is antiinflammatory and nonulcerogenic.Proceedings of the National Academy of Sciences of the United States of America, 91
P. Rajakumar, A. Rasheed, A. Rabia, D. Chamundeeswari (2006)
Synthesis and study of anti-inflammatory activity of some novel cyclophane amides.Bioorganic & medicinal chemistry letters, 16 23
H. Takahata, H. Ouchi, Yoko Kawata, M. Ono, Y. Morita, Yutaka Yamamoto (2004)
Regioselective Aromatic Substitution of 6,8-Dihydroxy-4-ethoxycarbonyl-2H-isoquinolin-1-one Derivatives Using the Stille Coupling ReactionHeterocycles, 62
T. Matsui, T. Sugiura, H. Nakai, S. Iguchi, S. Shigeoka, H. Takada, Y. Odagaki, Y. Nagao, Y. Ushio, K. Ohmoto (1992)
Novel 5-HT3 antagonists. Isoquinolinones and 3-aryl-2-pyridones.Journal of medicinal chemistry, 35 18
Obaid-ur-Rahman Abid, T. Babar, F. Ali, Shahzad Ahmed, A. Wadood, N. Rama, R. Uddin, Zaheer-ul-Haq, Ajmal Khan, M. Choudhary (2010)
Identification of novel urease inhibitors by high-throughput virtual and in vitro screening.ACS medicinal chemistry letters, 1 4
A. Sugimoto, Hisako Shinba-Tanaka, M. Ishikawa (1995)
A New Synthetic Route to Isoquinolin-1(2H)-one Derivatives from 3-HydroxyphthalidesSynthesis, 1995
M. Mor, S. Rivara, D. Pala, A. Bedini, G. Spadoni, G. Tarzia (2010)
Recent advances in the development of melatonin MT1 and MT2 receptor agonistsExpert Opinion on Therapeutic Patents, 20
P. Rajakumar, R. Anandhan (2011)
Synthesis and in-vitro anti-inflammatory activity of novel glycodendrimers with benzene 1,3,5 carboxamide core and triazole as branching unit.European journal of medicinal chemistry, 46 9
Feng Wang, Hongxia Liu, H. Fu, Yuyang Jiang, Yufen Zhao (2009)
An efficient one-pot copper-catalyzed approach to isoquinolin-1(2H)-one derivatives.Organic letters, 11 11
P. Ertl, B. Rohde, P. Selzer (2000)
Fast calculation of molecular polar surface area as a sum of fragment-based contributions and its application to the prediction of drug transport properties.Journal of medicinal chemistry, 43 20
(Figure not available: see fulltext.)
Medicinal Chemistry Research – Springer Journals
Published: May 21, 2014
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.