Access the full text.
Sign up today, get DeepDyve free for 14 days.
E. Angelopoulos, A. Maillis, A. Andreou, E. Koutsoukos, C. Stefanis, S. Loukas, C. Zioudrou (1990)
Effects of iontophoretically applied alpha-casein exorphin on CA1 hippocampal field potentials in vivo.Progress in clinical and biological research, 328
G. Paxinos, Charles Watson (1983)
The Rat Brain in Stereotaxic Coordinates
R. Dingledine (1981)
Possible mechanisms of enkephalin action on hippocampal CA1 pyramidal neurons, 1
P. Andersen (1960)
Interhippocampal impulses. II. Apical dendritic activation of CAI neurons.Acta physiologica Scandinavica, 48
C. Xie, D. Lewis (1991)
Opioid-mediated facilitation of long-term potentiation at the lateral perforant path-dentate granule cell synapse.The Journal of pharmacology and experimental therapeutics, 256 1
J. Slack, S. Pockett (1991)
Cyclic AMP induces long-term increase in synaptic efficacy in CA1 region of rat hippocampusNeuroscience Letters, 130
R. Neuman, C. Harley (1983)
Long-lasting potentiation of the dentate gyrus population spike by norepinephrineBrain Research, 273
H. Lee, T. Dunwiddie, B. Hoffer (1980)
Electrophysiological interactions of enkephalins with neuronal circuitry in the rat hippocampus. II. Effects on interneuron excitabilityBrain Research, 184
F. Tortella (1988)
Endogenous opioid peptides and epilepsy: quieting the seizing brain?Trends in pharmacological sciences, 9 10
T. Wimpey, K. Opheim, C. Chavkin (1989)
Effects of chronic morphine administration on the mu and delta opioid responses in the CA1 region of the rat hippocampus.The Journal of pharmacology and experimental therapeutics, 251 2
P. Marek, S. Ben-Eliyahu, M. Gold, J. Liebeskind (1991)
Excitatory amino acid antagonists (kynurenic acid and MK-801) attenuate the development of morphine tolerance in the ratBrain Research, 547
R. Nicoll, Bradley Alger, Craig Jahr (1980)
Enkephalin blocks inhibitory pathways in the vertebrate CNSNature, 287
B. Derrick, S. Weinberger, J. Martinez (1991)
Opioid receptors are involved in an NMDA receptor-independent mechanism of LTP induction at hippocampal mossy fiber-CA3 synapsesBrain Research Bulletin, 27
S. Paterson, L. Robson, H. Kosterlitz (1983)
Classification of opioid receptors.British medical bulletin, 39 1
J. Fry, W. Zieglgänsberger, A. Herz (1979)
Specific versus non-specific actions of opioids on hippocampal neurones in the rat brainBrain Research, 163
R. North (1986)
Opioid receptor types and membrane ion channelsTrends in Neurosciences, 9
J. Neumaier, S. Mailheau, C. Chavkin (1988)
Opioid receptor-mediated responses in the dentate gyrus and CA1 region of the rat hippocampus.The Journal of pharmacology and experimental therapeutics, 244 2
W. Zieglgänsberger, W. Zieglgänsberger, E. French, G. Siggins, F. Bloom (1979)
Opioid peptides may excite hippocampal pyramidal neurons by inhibiting adjacent inhibitory interneurons.Science, 205 4404
M. Plager, B. Vogt (1988)
μ- and δ-opioid receptor binding peaks and κ-homogeneity in the molecular layers of rat hippocampal formationBrain Research, 460
G. Lynch, R. Jensen, J. McGaugh, K. Davila, M. Oliver (1981)
Effects of enkephalin, morphine, and naloxone on the electrical activity of the in vitro hippocampal slice preparationExperimental Neurology, 71
Robert Goodman, S. Snyder, M. Kuhar, W. Young (1980)
Differentiation of delta and mu opiate receptor localizations by light microscopic autoradiography.Proceedings of the National Academy of Sciences of the United States of America, 77 10
K. Trujillo, H. Akil (1991)
Inhibition of morphine tolerance and dependence by the NMDA receptor antagonist MK-801.Science, 251 4989
M. Wollemann (1990)
Recent Developments in the Research of Opioid Receptor Subtype Molecular CharacterizationJournal of Neurochemistry, 54
G. Siggins, W. Zieglgänsberger (1981)
Morphine and opioid peptides reduce inhibitory synaptic potentials in hippocampal pyramidal cells in vitro without alteration of membrane potential.Proceedings of the National Academy of Sciences of the United States of America, 78 8
T. Dunwiddie, A. Mueller, M. Palmer, J. Stewart, B. Hoffer (1980)
Electrophysiological interactions of enkephalins with neuronal circuitry in the rat hippocampus. I. Effects on pyramidal cell activityBrain Research, 184
Horace Loh, Andrew Smith (1990)
Molecular characterization of opioid receptors.Annual review of pharmacology and toxicology, 30
S. Deadwyler, J. West, C. Cotman, G. Lynch (1975)
A neurophysiological analysis of commissural projections to dentate gyrus of the rat.Journal of neurophysiology, 38 1
C. Bramham, M. Er̀rington, T. Bliss (1988)
Naloxone blocks the induction of long-term potentiation in the lateral but not in the medial perforant pathway in the anesthetized ratBrain Research, 449
C. Bramham, N. Milgram, B. Srebro (1991)
δ Opioid receptor activation is required to induce LTP of synaptic transmission in the lateral perforant path in vivoBrain Research, 567
B. Crain, Kwen-Jen Chang, J. McNamara (1986)
Quantitative autoradiographic analysis of Mu and delta opioid binding sites in the rat hippocampal formationJournal of Comparative Neurology, 246
John Robinson, C. Dunlap, S. Deadwyler (1982)
Differences in opiate-induced synaptic excitability of hippocampal slices prepared from tolerant and nontolerant ratsExperimental Neurology, 77
B. Gähwiler (1981)
Development of acute tolerance during exposure of hippocampal explants to an opoid peptideBrain Research, 217
S. McLean, R. Rothman, A. Jacobson, K. Rice, M. Herkenham (1987)
Distribution of opiate receptor subtypes and enkephalin and dynorphin immunoreactivity in the hippocampus of squirrel, guinea pig, rat, and hamsterJournal of Comparative Neurology, 255
Prolonged iontophoretic administrations of δ‐ and μ‐selective opioid receptor agonists were conducted in the hippocampus of rats, in order to study the possible development of acute tolerance to the excitatory effects of the opioids. Acute tolerance (AT) to the excitatory effects of the 8‐selective opioid receptor agonist Tyr‐D‐Ser‐Gly‐Phe‐Leu‐Thr (DSLET) was observed when the drug was applied locally for 3–5 min in the CA1 hippocampal pyramidal neurons. The acute tolerance was expressed as a decrease in the commissurally evoked spike responsiveness during peptide's administration and led to a long‐lasting potentiation of the population spike (PS) upon its withdrawal. In all cases, where AT and spike potentiation were evident, the population excitatory postsynaptic potential (pEPSP) remained unaltered. Pharmacological studies of AT and long‐lasting spike potentiation showed the following: (1) the non‐selective opioid receptor antagonist, naloxone, while effective in blocking the excitatory effects of DSLET when applied prior and during the application of the latter, failed to exhibit and effect on the long‐lasting potentiating effect of the opioid; and (2) during the spike potentiation phase, administration of DSLET exhibited a depressant effect towards baseline values. This depressant effect of the opioid was evident 2–3 min from the beginning of the application and was completely antagonized by naloxone. The above results show that the development of acute tolerance to the excitatory effects of the DSLET led to long‐lasting spike potentiation, which manifests a withdrawal phenomenon. © 1995 Wiley‐Liss, Inc.
Journal of Neuroscience Research – Wiley
Published: Jan 1, 1995
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.