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Selenium and other mineral elements in populations at risk for esophageal cancer

Selenium and other mineral elements in populations at risk for esophageal cancer The current study tested the hypothesis that deficiencies of certain mineral elements are risk factors for esophageal cancer (EC). In rural blacks living in areas with moderate to high EC incidence rates in southern Africa, the whole blood selenium (Se) levels were found to be significantly (P < 0.0005) lower (58 to 71 ng/ml) than those of rural and urban populations living in low EC rate areas (114 to 177 ng/ ml). No significant differences were found in the plasma levels of the other mineral elements examined, including zinc, copper, and magnesium. Within a high EC rate area occupants of households with previously recorded EC cases had significantly (P < 0.0025) lower levels of Se (64 ng/ml), but not of other mineral elements, than subjects from households without known cases (77 ng/ml). Mean Se levels of subjects with premalignant or malignant esophageal cytological changes (54 ng/ml) were significantly (P < 0.0025) lower than those of subjects without such lesions (68 ng/ml). An inverse relationship was found between Se status and the degree of cytologic abnormality. These findings suggest that Se deficiency may play a role in the development of EC. The potential value of whole blood Se determinations and esophageal cytologic examinations in the early detection and of Se supplementation in the prevention of EC merits further investigation. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Cancer Wiley

Selenium and other mineral elements in populations at risk for esophageal cancer

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References (37)

Publisher
Wiley
Copyright
Copyright © 1988 American Cancer Society
ISSN
0008-543X
eISSN
1097-0142
DOI
10.1002/1097-0142(19881215)62:12<2635::AID-CNCR2820621232>3.0.CO;2-5
Publisher site
See Article on Publisher Site

Abstract

The current study tested the hypothesis that deficiencies of certain mineral elements are risk factors for esophageal cancer (EC). In rural blacks living in areas with moderate to high EC incidence rates in southern Africa, the whole blood selenium (Se) levels were found to be significantly (P < 0.0005) lower (58 to 71 ng/ml) than those of rural and urban populations living in low EC rate areas (114 to 177 ng/ ml). No significant differences were found in the plasma levels of the other mineral elements examined, including zinc, copper, and magnesium. Within a high EC rate area occupants of households with previously recorded EC cases had significantly (P < 0.0025) lower levels of Se (64 ng/ml), but not of other mineral elements, than subjects from households without known cases (77 ng/ml). Mean Se levels of subjects with premalignant or malignant esophageal cytological changes (54 ng/ml) were significantly (P < 0.0025) lower than those of subjects without such lesions (68 ng/ml). An inverse relationship was found between Se status and the degree of cytologic abnormality. These findings suggest that Se deficiency may play a role in the development of EC. The potential value of whole blood Se determinations and esophageal cytologic examinations in the early detection and of Se supplementation in the prevention of EC merits further investigation.

Journal

Cancer – Wiley

Published: Dec 15, 1988

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