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F. Nicoletti, J. Wroblewski, E. Costa (1987)
Magnesium Ions Inhibit the Stimulation of Inositol Phospholipid Hydrolysis by Endogenous Excitatory Amino Acids in Primary Cultures of Cerebellar Granule CellsJournal of Neurochemistry, 48
M. Manthorpe, J. Rudge, S. Varon (1986)
ASTROGLIAL CELL CONTRIBUTIONS TO NEURONAL SURVIVAL AND NEURITIC GROWTH
SN Murphy, Samuel Thayer, R.J. Miller (1987)
The effects of excitatory amino acids on intracellular calcium in single mouse striatal neurons in vitro, 7
J. Watkins, R. Evans (1981)
Excitatory amino acid transmitters.Annual review of pharmacology and toxicology, 21
Rudge Rudge, Manthorpe Manthorpe, Varon Varon (1985)
The output of neuronotrophic and neurite‐promoting agents from rat brain astroglial cells: A microculture method for screening potential regulatory moleculesDev. Brain Res., 19
J. Drejer, T. Honoré (1988)
New quinoxalinediones show potent antagonism of quisqualate responses in cultured mouse cortical neuronsNeuroscience Letters, 87
C. Downes (1986)
Agonist-stimulated phosphatidylinositol 4,5-bisphosphate metabolism in the nervous systemNeurochemistry International, 9
N. Abbott (1985)
Are glial cells excitable after all?Trends in Neurosciences, 8
A. Foster, G. Fagg (1984)
Acidic amino acid binding sites in mammalian neuronal membranes: their characteristics and relationship to synaptic receptorsBrain Research Reviews, 7
T. Ritchie, R. Cole, H. Kim, J. Vellis, E. Noble (1987)
Inositol phospholipid hydrolysis in cultured astrocytes and oligodendrocytes.Life sciences, 41 1
Wroblewski Wroblewski, Nicoletti Nicoletti, Fadda Fadda, Mazzetta Mazzetta, Costa Costa (1987)
Pertussis toxin inhibits the stimulation of inositol phospholipid hydrolysis by glutamate in primary cultures of cerebellar neuronsSoc. Neurosci. Abstr., 13
Novelli Novelli, Henneberry Henneberry (1987)
CGMP synthesis in cultured cerebellar neurons is stimulated by glutamate via a Ca 2+ ‐mediated, differentiation dependent mechanismDev. Brain Res., 34
A. MacDermott, M. Mayer, G. Westbrook, Stephen Smith, J. Barker (1986)
NMDA-receptor activation increases cytoplasmic calcium concentration in cultured spinal cord neuronesNature, 321
S. Rittenhouse, J. Sasson (1985)
Mass changes in myoinositol trisphosphate in human platelets stimulated by thrombin. Inhibitory effects of phorbol ester.The Journal of biological chemistry, 260 15
S. Corvera, K. Schwarz, R. Graham, J. García-Sáinz (1986)
Phorbol esters inhibit alpha 1-adrenergic effects and decrease the affinity of liver cell alpha 1-adrenergic receptors for (-)-epinephrine.The Journal of biological chemistry, 261 2
Kimelberg Kimelberg (1983)
Primary astrocyte cultures—A key to astrocyte functionCell Mol. Neurobiol., 3
S. Orellana, P. Solski, J. Brown (1985)
Phorbol ester inhibits phosphoinositide hydrolysis and calcium mobilization in cultured astrocytoma cells.The Journal of biological chemistry, 260 9
R. Gonzales, P. Greger, S. Baker, N. Ganz, C. Bolden, M. Raizada, F. Crews (1987)
Phorbol esters inhibit agonist-stimulated phosphoinositide hydrolysis in neuronal primary cultures.Brain research, 465 1-2
V. Gallo, M. Ciotti, A. Coletti, F. Aloisi, G. Levi (1982)
Selective release of glutamate from cerebellar granule cells differentiating in culture.Proceedings of the National Academy of Sciences of the United States of America, 79 24
K. Ackermann, B. Gish, M. Honchar, W. Sherman (1987)
Evidence that inositol 1-phosphate in brain of lithium-treated rats results mainly from phosphatidylinositol metabolism.The Biochemical journal, 242 2
M. Goldberg, J. Weiss, P. Pham, D. Choi (1987)
N-methyl-D-aspartate receptors mediate hypoxic neuronal injury in cortical culture.The Journal of pharmacology and experimental therapeutics, 243 2
A. Heiman, F. Crews (1985)
Characterization of the effects of phorbol esters on rat mast cell secretion.Journal of immunology, 134 1
Foster Foster, Fagg Fagg (1984)
Acidic amino acid binding sites in mammalian neuronal membranes: Their relationship to synaptic receptorsBrain Res. Rev., 7
N. Dean, J. Moyer (1987)
Separation of multiple isomers of inositol phosphates formed in GH3 cells.The Biochemical journal, 242 2
Ferdinando Nicoletti, J. Wroblewski, A. Novelli, H. Alho, Alessandro Guidotti, Erminio Costa (1986)
The activation of inositol phospholipid metabolism as a signal- transducing system for excitatory amino acids in primary cultures of cerebellar granule cells, 6
S. Vibulsreth, F. Hefti, M. Ginsberg, W. Dietrich, R. Busto (1987)
Astrocytes protect cultured neurons from degeneration induced by anoxiaBrain Research, 422
Ferdinando Nicoletti, J. Wroblewski, Hannu Alho, C. Eva, E. Fadda, Erminio Costa (1987)
Lesions of putative glutamatergic pathways potentiate the increase of inositol phospholipid hydrolysis elicited by excitatory amino acidsBrain Research, 436
Milani Milani, Facci Facci, Leon Leon, Skaper Skaper (1988)
Excitatory amino acid neurotransmitter action in astroglial cells is linked to second messenger transduction pathwaysNeurochem. Int., 13
Y. Kudo, A. Ogura (1986)
Glutamate‐induced increase in intracellular Ca2+ concentration in isolated hippocampal neuronesBritish Journal of Pharmacology, 89
F. Sladeczek, M. Récasens, J. Bockaert (1988)
A new mechanism for glutamate receptor action: phosphoinositide hydrolysisTrends in Neurosciences, 11
F. Sladeczek, J. Pin, M. Récasens, J. Bockaert, S. Weiss (1985)
Glutamate stimulates inositol phosphate formation in striatal neuronesNature, 317
Corvera Corvera, Schwarz Schwarz, Graham Graham, Garcia‐Sainz Garcia‐Sainz (1986)
Phorbol esters inhibit α 1 ‐adrenergic receptors for (–)‐epinephrineJ. Biol. Chem., 261
K. Krnjevicacute (1982)
An excitatory amino Acid.Science, 216 4545
S. Rothman (1984)
Synaptic release of excitatory amino acid neurotransmitter mediates anoxic neuronal death, 4
Palmer Palmer, Monaghan Monaghan, Cotman Cotman (1988)
Glutamate receptors and phosphoinositide metabolism: Stimulation via quisqualate receptors is inhibited by N‐methyl‐D‐aspartate receptor activationMol. Brain Res., 4
Helmut Kettenmann, M. Schachner (1985)
Pharmacological properties of gamma-aminobutyric acid-, glutamate-, and aspartate-induced depolarizations in cultured astrocytes, 5
Brian Pearce, C. Morrow, Sean Murphy (1986)
Receptor-mediated inositol phospholipid hydrolysis in astrocytes.European journal of pharmacology, 121 2
G. Fagg (1985)
l-Glutamate, excitatory amino acid receptors and brain functionTrends in Neurosciences, 8
A. Novelli, F. Nicoletti, J. Wroblewski, H. Alho, E. Costa, A. Guidotti (1987)
Excitatory amino acid receptors coupled with guanylate cyclase in primary cultures of cerebellar granule cells, 7
John Rudge, M. Manthorpe, Silvio Varon (1985)
The output of neuronotrophic and neurite-promoting agents from rat brain astroglial cells: a microculture method for screening potential regulatory molecules.Brain research, 351 2
A. Novelli, R. Henneberry (1987)
cGmp synthesis in cultured cerebellar neurons is stimulated by glutamate via a Ca2+-mediated, differentiation-dependent mechanism.Brain research, 431 2
J. Johnson, P. Ascher (1987)
Glycine potentiates the NMDA response in cultured mouse brain neuronsNature, 325
(1987)
Central receptors for N-methyl-D-aspartate and ibotenate are distinct
V. Pribluda, H. Metzger (1987)
Calcium-independent phosphoinositide breakdown in rat basophilic leukemia cells. Evidence for an early rise in inositol 1,4,5-trisphosphate which precedes the rise in other inositol phosphates and in cytoplasmic calcium.The Journal of biological chemistry, 262 24
E. Palmer, D. Monaghan, C. Cotman (1988)
Glutamate receptors and phosphoinositide metabolism: stimulation via quisqualate receptors is inhibited by N-methyl-D-aspartate receptor activation.Brain research, 464 2
Mayer Mayer, Westbrook Westbrook (1984)
Mixed agonist action of excitatory amino acids in voltage clamped mouse spinal neuronesJ. Physiol. (Lond.), 354
B. Pearce, C. Morrow, S. Murphy (1988)
A role for protein kinase C in astrocyte glycogen metabolismNeuroscience Letters, 90
H. Streb, R. Irvine, M. Berridge, I. Schulz (1983)
Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphateNature, 306
M. Berridge, R. Irvine (1984)
Inositol trisphosphate, a novel second messenger in cellular signal transductionNature, 312
C. Bowman, H. Kimelberg (1984)
Excitatory amino acids directly depolarize rat brain astrocytes in primary cultureNature, 311
M. Berridge, R. Dawson, C. Downes, J. Heslop, R. Irvine (1983)
Changes in the levels of inositol phosphates after agonist-dependent hydrolysis of membrane phosphoinositides.The Biochemical journal, 212 2
M. Mayer, G. Westbrook (1984)
Mixed‐agonist action of excitatory amino acids on mouse spinal cord neurones under voltage clamp.The Journal of Physiology, 354
R. Schwarcz, G. Brush, A. Foster, E. French (1984)
Seizure activity and lesions after intrahippocampal quinolinic acid injectionExperimental Neurology, 84
G. Grynkiewicz, M. Poenie, Roger TsienB (1985)
A new generation of Ca2+ indicators with greatly improved fluorescence properties.The Journal of biological chemistry, 260 6
(1979)
Neuron - dial interactions
C. Jahr, Charles Stevens (1987)
Glutamate activates multiple single channel conductances in hippocampal neuronsNature, 325
Y. Nishizuka (1986)
Studies and perspectives of protein kinase C.Science, 233 4761
N. Takuwa, Y. Takuwa, W. Bollag, H. Rasmussen (1987)
The effects of bombesin on polyphosphoinositide and calcium metabolism in Swiss 3T3 cells.The Journal of biological chemistry, 262 1
J. Kemp, A. Foster, E. Wong (1987)
Non-competitive antagonists of excitatory amino acid receptorsTrends in Neurosciences, 10
Gonzales Gonzales, Greger Greger, Baker Baker, Ganz Ganz, Bolden Bolden, Raizada Raizada, Crews Crews (1987)
Phorbol esters inhibit agoniststimulated phosphoinositide hydrolysis in neuronal primary culturesDev. Brain Res., 37
P. Magistretti, M. Manthorpe, F. Bloom, S. Varon (1983)
Functional receptors for vasoactive intestinal polypeptide in cultured astroglia from neonatal rat brainRegulatory Peptides, 6
B. Pearce, J. Albrecht, C. Morrow, S. Murphy (1986)
Astrocyte glutamate receptor activation promotes inositol phospholipid turnover and calcium fluxNeuroscience Letters, 72
G. Burgess, J. Mckinney, R. Irvine, J. Putney (1985)
Inositol 1,4,5-trisphosphate and inositol 1,3,4-trisphosphate formation in Ca2+-mobilizing-hormone-activated cells.The Biochemical journal, 232 1
M. Mayer, G. Westbrook, P. Guthrie (1984)
Voltage-dependent block by Mg2+ of NMDA responses in spinal cord neuronesNature, 309
J. Neary, L. Norenberg, M. Norenberg (1986)
Calcium-activated, phospholipid-dependent protein kinase and protein substrates in primary cultures of astrocytesBrain Research, 385
Cholewinski Cholewinski, Hanley Hanley, Wilkin Wilkin (1988)
A phosphoinositide‐linked peptide response in astrocytes: Evidence for regional heterogeneityNeurochem. Res., 13
Excitatory amino acids (EAA) are known to induce an increase in the breakdown of polyphosphoinositides (PI) in brain slices and in dispersed cultures of neurons. We have now used astroglia cultured from newborn rat cerebra to demonstrate that glutamate provokes, in (3H)inositol‐labeled cells, an accumulation of inositol phosphates in a time‐ and concentration‐dependent manner. The ED50 value for glutamate was 40 μM. Quisqualate, ibotenate, and kainate were also active, with their relative potencies in the order of quisqualate > ibotenate >> kainate. No effect was detected with N‐methyl‐D‐aspartate and quinolinic acid in the absence of Mg2+. The nonselective glutamate receptor antagonist γ‐D‐glutamylglycine fully inhibited glutamate agonist‐induced PI breakdown. A brief pretreatment of the astroglial cells with phorbol esters negated these effects of EAA receptor agonists, suggesting a feedback role for protein kinase C in phospholipase C action. Glutamate also elevated cytosolic free Ca2+ in Fura‐2‐loaded astroglial cells, as assessed by digital fluorescence imaging microscopy. Since a close metabolic partnership is known to exist between neurons and glia, these findings may have important functional consequences for neural cells in vivo.
Glia – Wiley
Published: Jan 1, 1989
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