Access the full text.
Sign up today, get DeepDyve free for 14 days.
C. Westhoff, Sipherd Bd, Wylie De, Toalson Ld (1992)
Severe anaphylactic reactions following transfusions of platelets to a patient with anti‐ChTransfusion, 32
J. Harper, J. Gill, R. Hopp, John Evans, W. Haire (1995)
Induction of Immune Tolerance in a 7-Year-Old Hemophiliac with an Anaphylactoid InhibitorThrombosis and Haemostasis, 74
A. Dioun, Bruce Ewenstein, R. Geha, Lynda Schneider (1998)
IgE-mediated allergy and desensitization to factor IX in hemophilia B.The Journal of allergy and clinical immunology, 102 1
Wanda Dobryszycka (1997)
Biological functions of haptoglobin--new pieces to an old puzzle.European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies, 35 9
I. Warrier, J. Lusher (1998)
Development of anaphylactic shock in haemophilia B patients with inhibitors.Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 9 Suppl 1
L. Bergamaschini, P. Mannucci, A. Federici, R. Coppola, S. Guzzoni, Angelo Agostoni (1995)
Posttransfusion anaphylactic reactions in a patient with severe von Willebrand disease: role of complement and alloantibodies to von Willebrand factor.The Journal of laboratory and clinical medicine, 125 3
(1999)
Haemovigi- lance systems
Y. Koda, Yoshihisa Watanabe, M. Soejima, E. Shimada, M. Nishimura, Kaichiro Morishita, Susumu Moriya, Shigeki Mitsunaga, Kenji Tadokoro, Hiroshi Kimura (2000)
Simple PCR detection of haptoglobin gene deletion in anhaptoglobinemic patients with antihaptoglobin antibody that causes anaphylactic transfusion reactions.Blood, 95 4
N. Yoshioka, T. Yokoi, M. Nata, Hitomi Meguro, K. Morita, K. Sagisaka (1991)
Haptoglobin deficiency detected by DNA analysisSeibutsu Butsuri Kagaku, 35
Tadashi Kanoh, T. Mizumoto, Norimasa Yasuda, M. Koya, Y. Ohno, Haruto Uchino, K. Yoshimura, Y. Ohkubo, Hideo Yamaguchi (1986)
Selective IgA Deficiency in Japanese Blood Donors: Frequency and Statistical Analysis 1Vox Sanguinis, 50
Schwartz Schwartz (1994)
Laboratory assessment of immediate hypersen‐ sitivity and anaphylaxis. Use of tryptase as a marker of mast cell‐dependent events.Diagn Lab Immunol, 14
P. Lambin, P. Pennec, G. Hauptmann, O. Desaint, B. Habibi, C. Salmon (1984)
Adverse Transfusion Reactions Associated with a Precipitating Anti‐C4 Antibody of Anti‐Rodgers Specificity 1Vox Sanguinis, 47
A. Burks, H. Sampson, R. Buckley (1986)
Anaphylactic reactions after gamma globulin administration in patients with hypogammaglobulinemia. Detection of IgE antibodies to IgA.The New England journal of medicine, 314 9
Girish Vyas, H. Perkins, H. Fudenberg (1968)
Anaphylactoid transfusion reactions associated with anti-IgA.Lancet, 2 7563
A. Schmidt, H. Taswell, G. Gleich (1969)
Anaphylactic transfusion reactions associated with anti-IgA antibody.The New England journal of medicine, 280 4
(1992)
of platelets to a patient with antiCh
L. Schwartz (1994)
Laboratory assessment of immediate hypersensitivity and anaphylaxis: use of tryptase as a marker of mast cell-dependent eventsImmunology and Allergy Clinics of North America, 14
Katoh Katoh, Takashima Takashima, Kuroda Kuroda (1983)
(Transfusion reactions associated with anti‐haptoglobin).Jpn J Transf Med, 29
S. Sandler, Delores Mallory, D. Malamut, R. Eckrich (1995)
IgA anaphylactic transfusion reactions.Transfusion medicine reviews, 9 1
(1998)
Anti-haptoglobin antibody was detected in two patients with ahaptoglo- binemia, who suffered from anaphylactic transfusion re- actions] (abstract)
Kaichiro Morishita, E. Shimada, Y. Watanabe, H. Kimura (2000)
Anaphylactic transfusion reactions associated with anti‐haptoglobin in a patient with ahaptoglobinemiaTransfusion, 40
BACKGROUND : Patients with haptoglobin deficiency associated with haptoglobin IgG antibodies, who experienced severe nonhemolytic transfusion reactions (NHTRs), have been identified in Japan. Haptoglobin deficiency therefore might be a risk factor for NHTRs. STUDY DESIGN AND METHODS : A total of 4138 cases of voluntarily reported NHTRs in Japan, including 367 cases of immediate‐onset anaphylactic NHTRs, were examined to identify haptoglobin deficiency. Serum haptoglobin IgG and IgE antibodies were determined in haptoglobin‐deficient patients to elucidate the mechanism underlying the transfusion reactions. RESULTS : Seven patients with haptoglobin deficiency were identified. Six of them experienced severe and acute NHTRs. Six of them were identified to be homozygous for the Hp del allele of the haptoglobin gene. Both haptoglobin IgG and IgE antibodies were detected in serum samples of all the patients. The stimulative effects of blood transfusion on the production of hap‐ toglobin antibodies in the patients and the relation‐ ship between the presence of the antibodies and the occurrence of the transfusion reactions were observed. CONCLUSION : Anaphylactic NHTRs in these patients with haptoglobin deficiency associated with serum haptoglobin antibodies were suggested to be prevalent in Japan. In addition to IgG antibodies, IgE haptoglobin antibodies detected in the sera of such patients were suggested to play a role in the occurrence of the reactions.
Transfusion – Wiley
Published: Jun 1, 2002
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.